Search Results - "MARTINI, Jeffrey S"

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process by Gold, Jessica I, Martini, Jeffrey S, Hullmann, Jonathan, Gao, Erhe, Chuprun, J Kurt, Lee, Linda, Tilley, Douglas G, Rabinowitz, Joseph E, Bossuyt, Julie, Bers, Donald M, Koch, Walter J

“…G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following…”
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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes by Martini, Jeffrey S, Raake, Philip, Vinge, Leif E, DeGeorge, Brent Jr, Chuprun, J. Kurt, Harris, David M, Gao, Erhe, Eckhart, Andrea D, Pitcher, Julie A, Koch, Walter J

“…G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs…”
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Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress by DEGEORGE, Brent R, ERHE GAO, ECKHART, Andrea D, KOCH, Walter J, BOUCHER, Matthieu, VINGE, Leif E, MARTINI, Jeffrey S, RAAKE, Philip W, CHUPRUN, J. Kurt, HARRIS, David M, KIM, Gilbert W, SOLTYS, Stephen

“…A salient characteristic of dysfunctional myocardium progressing to heart failure is an upregulation of the adenylyl cyclase inhibitory guanine nucleotide (G)…”
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A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure by Martini, Jeffrey S, Koch, Walter J, Sparks, Li, Kardia, Sharon L R, Dorn II, Gerald W, Spertus, John A, Parekh, Rohan R, Matkovich, Scot J, Kelly, Reagan J, Liggett, Stephen B, Cresci, Sharon, Hahn, Harvey S, Diwan, Abhinav, Syed, Faisal M

“…β-adrenergic receptor (βAR) blockade is a standard therapy for cardiac failure and ischemia. G protein–coupled receptor kinases (GRKs) desensitize βARs,…”
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Nuclear Translocation of GRK5 Following Hypertrophic Stimuli Is a Calmodulin-Dependent Process by Gold, Jessica I, Martini, Jeffrey S, Chuprun, J. Kurt, Koch, Walter J

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Selectively Targeting Gi Signaling in Normal and Dysfunctional Myocardium by DeGeorge, Brent R, Gao, Erhe, Boucher, Matthieu, Vinge, Leif E, Martini, Jeffrey S, Raake, Philip W, Soltys, Stephen, Harris, David M, Chuprun, Kurt J, Eckhart, Andrea D, Koch, Walter J

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A Novel Nuclear Function for GRK5 and Its Potential Role in the Hypertrophic Response by Martini, Jeffrey S, Raake, Philip, Vinge, Leif E, DeGeorge, Brent R, Chuprun, John K, Harris, David M, Eckhart, Andrea E, Pitcher, Julie A, Koch, Walter J

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Abstract P195: Nuclear Translocation of GRK5 Following Hypertrophic Stimuli Is a Calmodulin-Dependent Process by Gold, Jessica I, Martini, Jeffrey S, Chuprun, J Kurt, Koch, Walter J

“…Abstract only Maladaptive ventricular hypertrophy often precedes the pathological endpoint of Heart Failure (HF). G protein Coupled Receptors (GPCRs), such as…”
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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of card iomyocytes by Martini, Jeffrey S, Raake, Philip, Vinge, Leif E, DeGeorge, Brent, Chuprun, J Kurt, Harris, David M, Gao, Erhe, Eckhart, Andrea D, Pitchert, Julie A, Koch, Walter J

“…G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs…”
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A GRK5 polymorphism that inhibits [beta]-adrenergic receptor signaling is protective in heart failure by Liggett, Stephen B, Cresci, Sharon, Kelly, Reagan J, Syed, Faisal M, Matkovich, Scot J, Hahn, Harvey S, Diwan, Abhinav, Martini, Jeffrey S, Sparks, Li, Parekh, Rohan R, Spertus, John A, Koch, Walter J, Kardia, Sharon L R, Dorn Ii, Gerald W

“…Beta-adrenergic receptor (betaAR) blockade is a standard therapy for cardiac failure and ischemia. G protein-coupled receptor kinases (GRKs) desensitize…”
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Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process. e57324 by Gold, Jessica I, Martini, Jeffrey S, Hullmann, Jonathan, Gao, Erhe, Chuprun, J Kurt, Lee, Linda, Tilley, Douglas G, Rabinowitz, Joseph E, Bossuyt, Julie, Bers, Donald M

“…G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following…”
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Abstract 1057: Specific Targeting of Gi Signaling in Normal and Dysfunctional Myocardium by DeGeorge, Brent R, Gao, Erhe, Boucher, Matthieu, Vinge, Leif E, Chuprun, J. K, Raake, Philip, Martini, Jeffrey S, Harris, David M, Soltys, Stephen, Eckhart, Andrea D, Koch, Walter J

“…Abstract only Evidence has accumulated to suggest that cardiomyocyte apoptosis contributes significantly to the progression of heart failure. A salient…”
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Uncovering G protein-coupled receptor kinase-5 as a novel histone deacetylase kinase by Martini, Jeffrey S

“…G Protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes GRK2 and GRK5 are two GRKs…”
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