Search Results - "MARTIEN, Sébastien"

Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis by Malaquin, Nicolas, Vercamer, Chantal, Bouali, Fatima, Martien, Sébastien, Deruy, Emeric, Wernert, Nicolas, Chwastyniak, Maggy, Pinet, Florence, Abbadie, Corinne, Pourtier, Albin

“…The incidence of carcinoma increases greatly with aging, but the cellular and molecular mechanisms underlying this correlation are only partly known. It is…”
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Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells by Nassour, Joe, Martien, Sébastien, Martin, Nathalie, Deruy, Emeric, Tomellini, Elisa, Malaquin, Nicolas, Bouali, Fatima, Sabatier, Laure, Wernert, Nicolas, Pinte, Sébastien, Gilson, Eric, Pourtier, Albin, Pluquet, Olivier, Abbadie, Corinne

“…The main characteristic of senescence is its stability which relies on the persistence of DNA damage. We show that unlike fibroblasts, senescent epithelial…”
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Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells by GOSSELIN, Karo, MARTIEN, Sébastien, MALAQUIN, Nicolas, WERNERT, Nicolas, SLIJEPCEVIC, Predrag, ASHTARI, Marjan, CHELLI, Fazia, DERUY, Emeric, VANDENBUNDER, Bernard, DE LAUNOIT, Yvan, ABBADIE, Corinne, POURTIER, Albin, VERCAMER, Chantal, OSTOICH, Peter, MORAT, Luc, SABATIER, Laure, DUPREZ, Laurence, T'KINT DE ROODENBEKE, Claire, GILSON, Eric

“…Studies on human fibroblasts have led to viewing senescence as a barrier against tumorigenesis. Using keratinocytes, we show here that partially transformed…”
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Acquisition of oxidative DNA damage during senescence: the first step toward carcinogenesis? by Martien, Sébastien, Abbadie, Corinne

“…As a result of time and cumulative divisions in vitro and in vivo, normal cells enter an irreversible nonproliferative state termed replicative or cellular…”
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Regulation of ploidy and senescence by the AMPK-related kinase NUAK1 by Humbert, Nicolas, Navaratnam, Naveenan, Augert, Arnaud, Da Costa, Marco, Martien, Sébastien, Wang, Jing, Martinez, Dolores, Abbadie, Corinne, Carling, David, de Launoit, Yvan, Gil, Jesus, Bernard, David

“…Senescence is an irreversible cell‐cycle arrest that is elicited by a wide range of factors, including replicative exhaustion. Emerging evidences suggest that…”
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Senescent Keratinocytes Die by Autophagic Programmed Cell Death by Gosselin, Karo, Deruy, Emeric, Martien, Sébastien, Vercamer, Chantal, Bouali, Fatima, Dujardin, Thibault, Slomianny, Christian, Houel-Renault, Ludivine, Chelli, Fazia, De Launoit, Yvan, Abbadie, Corinne

“…Normal cells reach senescence after a specific time and number of divisions, leading ultimately to cell death. Although escape from this fate may be a…”
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MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes by Deruy, Emeric, Gosselin, Karo, Vercamer, Chantal, Martien, Sébastien, Bouali, Fatima, Slomianny, Christian, Bertout, Julie, Bernard, David, Pourtier, Albin, Abbadie, Corinne

“…Senescence is a state of growth arrest resulting mainly from telomere attrition and oxidative stress. It ultimately leads to cell death. We have previously…”
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Normal or stress-induced fibroblast senescence involves COX-2 activity by Zdanov, Stéphanie, Bernard, David, Debacq-Chainiaux, Florence, Martien, Sébastien, Gosselin, Karo, Vercamer, Chantal, Chelli, Fazia, Toussaint, Olivier, Abbadie, Corinne

“…Cyclooxygenase-2 (COX-2) is an inducible enzyme of the prostaglandin biosynthesis pathway . It is involved in many stress responses, and its activity can…”
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A Genetic Screen Identifies Topoisomerase 1 as a Regulator of Senescence by HUMBERT, Nicolas, MARTIEN, Sébastien, AUGERT, Arnaud, DA COSTA, Marco, MAUEN, Sébastien, ABBADIE, Corinne, DE LAUNOIT, Yvan, GIL, Jesús, BERNARD, David

“…Normal cell growth can be permanently blocked when cells enter a state known as senescence. This phenomenon can be triggered by various stresses, such as…”
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Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts by Martien, Sébastien, Pluquet, Olivier, Vercamer, Chantal, Malaquin, Nicolas, Martin, Nathalie, Gosselin, Karo, Pourtier, Albin, Abbadie, Corinne

“…Cyclooxygenase 2 and release of prostaglandin E2 are involved in many responses including inflammation and are upregulated during cellular senescence. However,…”
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Acquisition of Oxidative DNA Damage during Senescence by MARTIEN, SÉBASTIEN, ABBADIE, CORINNE

“…:  As a result of time and cumulative divisions in vitro and in vivo, normal cells enter an irreversible nonproliferative state termed replicative or cellular…”
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Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts by Martien, Sébastien, Pluquet, Olivier, Vercamer, Chantal, Malaquin, Nicolas, Martin, Nathalie, Gosselin, Karo, Pourtier, Albin Dr, Abbadie, Corinne

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Senescent Fibroblasts Enhance Early Skin Carcinogenic Events via a Paracrine MMP-PAR-1 Axis by Malaquin, Nicolas, Vercamer, Chantal, Bouali, Fatima, Martien, Sébastien, Deruy, Emeric, Wernert, Nicolas, Chwastyniak, Maggy, Pinet, Florence, Abbadie, Corinne, Pourtier, Albin Dr

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MnSOD Upregulation Induces Autophagic Programmed Cell Death in Senescent Keratinocytes by Deruy, Emeric, Gosselin, Karo, Vercamer, Chantal, Martien, Sébastien, Bouali, Fatima, Slomianny, Christian, Bertout, Julie, Bernard, David, Pourtier, Albin Dr, Abbadie, Corinne

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Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts by Martien, Sébastien, Pluquet, Olivier, Vercamer, Chantal, Malaquin, Nicolas, Martin, Nathalie, Gosselin, Karo, Pourtier, Albin, Abbadie, Corinne

“…Cyclooxygenase 2 and release of prostaglandin E2 are involved in many responses including inflammation and are upregulated during cellular senescence. However,…”
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Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells by Gosselin, Karo, Martien, Sébastien, Pourtier, Albin Dr, Vercamer, Chantal, Ostoich, Peter, Morat, Luc, Sabatier, Laure, Duprez, Laurence, t'Kint de Roodenbeke, Claire, Gilson, Eric, Malaquin, Nicolas, Wernert, Nicolas, Slijepcevic, Predrag, Ashtari, Marjan, Chelli, Fazia, Deruy, Emeric, Vandenbunder, Bernard, de Launoit, Yvan, Abbadie, Corinne

“…Abstract Studies on human fibroblasts have led to viewing senescence as a barrier against tumorigenesis. Using keratinocytes, we show here that partially…”
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Senescent Fibroblasts Enhance Early Skin Carcinogenic Events via a Paracrine MMP-PAR-1 Axis. e63607 by Malaquin, Nicolas, Vercamer, Chantal, Bouali, Fatima, Martien, Sebastien, Deruy, Emeric, Wernert, Nicolas, Chwastyniak, Maggy, Pinet, Florence, Abbadie, Corinne, Pourtier, Albin

“…The incidence of carcinoma increases greatly with aging, but the cellular and molecular mechanisms underlying this correlation are only partly known. It is…”
Get full text