Search Results - "MARTIAL, Joseph"
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MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy
Published in The Journal of clinical investigation (01-05-2013)“…Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the…”
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MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells
Published in PloS one (10-02-2011)“…MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the…”
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Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer
Published in Oncotarget (30-04-2015)“…The interaction between tumor cells and their microenvironment is an essential aspect of tumor development. Therefore, understanding how this microenvironment…”
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Plasminogen Activator Inhibitor-1 Protects Endothelial Cells from FasL-Mediated Apoptosis
Published in Cancer cell (07-10-2008)“…Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known…”
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Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development
Published in Differentiation (London) (01-11-2013)“…Cranial cartilage derives mainly from cranial neural crest cells and its formation requires fibroblast growth factor (Fgf) signaling for early differentiation…”
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The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis
Published in Science signaling (17-11-2015)“…In endothelial cells, binding of vascular endothelial growth factor (VEGF) to the receptor VEGFR2 activates multiple signaling pathways that trigger processes…”
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RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish
Published in PloS one (27-11-2012)“…The cartilaginous elements forming the pharyngeal arches of the zebrafish derive from cranial neural crest cells. Their proper differentiation and patterning…”
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Combined bulk-rock Lu-Hf and Sm-Nd isotopic study of Archean granitoids and mafic rocks from Sangmelima terranes (Ntem Complex, south Cameroon): Geodynamic implications
Published in Precambrian research (15-07-2023)“…Based on the geological, geochemical and isotopic data, multi-stage magmatism, crustal reworking and growth events occurred in the Ntem Complex at ∼3.90–3.25…”
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Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration
Published in Developmental biology (15-06-2012)“…Recent zebrafish studies have shown that the late appearing pancreatic endocrine cells are derived from pancreatic ducts but the regulatory factors involved…”
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PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin
Published in Nature medicine (01-07-2014)“…The antiangiogenic and profibrinolytic activities of the N-terminal fragment of prolactin, 16K PRL, are mediated by its binding to the protein PAI-1. The…”
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Different policy instruments and the threshold effects on collaboration efficiency in China
Published in Science & public policy (01-06-2020)“…Abstract University–industry R&D collaboration is an important means to improve innovation efficiency; many governments have issued policies to promote it. The…”
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Zebrafish Sox7 and Sox18 function together to control arterial–venous identity
Published in Developmental biology (15-05-2008)“…Sox7 and Sox18 are members of the F-subgroup of Sox transcription factors family and are mostly expressed in endothelial compartments. In humans, dominant…”
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Fast homozygosity mapping and identification of a zebrafish ENU-induced mutation by whole-genome sequencing
Published in PloS one (04-04-2012)“…Forward genetics using zebrafish is a powerful tool for studying vertebrate development through large-scale mutagenesis. Nonetheless, the identification of the…”
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A Focus Group Study to Understand the Perspectives of Physiotherapists on Barriers and Facilitators to Advancing Rehabilitation in Low-Resource and Conflict Settings
Published in International journal of environmental research and public health (16-11-2021)“…Physiotherapy as a health profession is continuously evolving in high-income countries (HIC). The highest burden of disease globally, however, is in…”
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A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos
Published in Reproductive toxicology (Elmsford, N.Y.) (01-12-2012)“…► We tested pharmacological pollutants on zebrafish by treatment between 48 and 72h post-fertilization. ► Assessing lethality, a higher sensitivity was…”
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A peptide mimicking the C-terminal part of the reactive center loop induces the transition to the latent form of plasminogen activator inhibitor type-1
Published in FEBS letters (23-03-2012)“…► PAI-1 RCL peptides inhibit the formation of complexes between PAI-1 and uPA/tPA. ► Peptide RCLp14-9 of PAI-1 induces the substrate behavior of the serpin. ►…”
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Octarellin VI: using rosetta to design a putative artificial (β/α)8 protein
Published in PloS one (2013)“…The computational protein design protocol Rosetta has been applied successfully to a wide variety of protein engineering problems. Here the aim was to test its…”
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The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools
Published in Journal of structural biology (01-07-2016)“…Despite impressive successes in protein design, designing a well-folded protein of more 100 amino acids de novo remains a formidable challenge. Exploiting the…”
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Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis
Published in PLoS neglected tropical diseases (01-07-2012)“…Treatment of urinary schistosomiasis by chemotherapy remains challenging due to rapid re-infection and possibly to limited susceptibility to praziquantel…”
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Functional Nanogels as Platforms for Imparting Antibacterial, Antibiofilm, and Antiadhesion Activities to Stainless Steel
Published in Advanced functional materials (19-12-2012)“…In this work, long‐term antibacterial, antiadhesion, and antibiofilm activities are afforded to industrial stainless steel surfaces following a green and…”
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