Search Results - "MARTELLI, A"

Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review by Banderali, G, Martelli, A, Landi, M, Moretti, F, Betti, F, Radaelli, G, Lassandro, C, Verduci, E

“…A great deal of attention has been focused on adverse effects of tobacco smoking on conception, pregnancy, fetal, and child health. The aim of this paper is to…”
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Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cells by Martelli, A M, Evangelisti, C, Follo, M Y, Ramazzotti, G, Fini, M, Giardino, R, Manzoli, L, McCubrey, J A, Cocco, L

“…Cancer stem cells (CSCs) comprise a subset of hierarchically organized, rare cancer cells with the ability to initiate cancer in xenografts of genetically…”
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Roles of the Ras Raf MEK ERK pathway in leukemia therapy by Steelman, L S, Franklin, R A, Abrams, S L, Chappell, W, Kempf, C R, Bäsecke, J, Stivala, F, Donia, M, Fagone, P, Nicoletti, F, Libra, M, Ruvolo, P, Ruvolo, V, Evangelisti, C, Martelli, A M, McCubrey, J A

“…The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to…”
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Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs by Testai, L., Rapposelli, S., Martelli, A., Breschi, M.C., Calderone, V.

“…Brief periods of ischemia are known to confer to the myocardium an increased resistance to the injury due to a later and more prolonged ischemic episode. This…”
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Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K PTEN Akt mTOR pathway by Martelli, A M, Evangelisti, C, Chappell, W, Abrams, S L, Bäsecke, J, Stivala, F, Donia, M, Fagone, P, Nicoletti, F, Libra, M, Ruvolo, V, Ruvolo, P, Kempf, C R, Steelman, L S, McCubrey, J A

“…It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation. The…”
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Therapeutic targeting of CK2 in acute and chronic leukemias by Buontempo, F, McCubrey, J A, Orsini, E, Ruzzene, M, Cappellini, A, Lonetti, A, Evangelisti, C, Chiarini, F, Evangelisti, C, Barata, J T, Martelli, A M

“…CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is considered the most pleiotropic protein kinase in the human kinome…”
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Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: Classification, differences and relevance in preclinical and clinical studies by Martelli, A., d’Emmanuele di Villa Bianca, R., Cirino, G., Sorrentino, R., Calderone, V., Bucci, M.

“…Hydrogen sulfide (H2S) has been extensively studied as a signal molecule in the body for the past 30 years. Researchers have conducted studies using both…”
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Targeting the leukemic stem cell: the Holy Grail of leukemia therapy by Misaghian, N, Ligresti, G, Steelman, L S, Bertrand, F E, Bäsecke, J, Libra, M, Nicoletti, F, Stivala, F, Milella, M, Tafuri, A, Cervello, M, Martelli, A M, McCubrey, J A

“…Since the discovery of leukemic stem cells (LSCs) over a decade ago, many of their critical biological properties have been elucidated, including their…”
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Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention by McCubrey, J A, Steelman, L S, Bertrand, F E, Davis, N M, Abrams, S L, Montalto, G, D'Assoro, A B, Libra, M, Nicoletti, F, Maestro, R, Basecke, J, Cocco, L, Cervello, M, Martelli, A M

“…Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat…”
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Phosphoinositide 3-kinase Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia by MARTELLI, A. M, NYAKERN, M, TABELLINI, G, BORTUL, R, TAZZARI, P. L, EVANGELISTI, C, COCCO, L

“…The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is crucial to many aspects of cell growth, survival and apoptosis, and its constitutive activation…”
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Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential by Neri, L M, Cani, A, Martelli, A M, Simioni, C, Junghanss, C, Tabellini, G, Ricci, F, Tazzari, P L, Pagliaro, P, McCubrey, J A, Capitani, S

“…B-precursor acute lymphoblastic leukemia (B-pre ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. The prognosis…”
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Persulfidation of mitoKv7.4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia/reperfusion injury by Testai, L., Montanaro, R., Flori, L., Pagnotta, E., Vellecco, V., Gorica, E., Ugolini, L., Righetti, L., Brancaleone, V., Bucci, M., Piragine, E., Martelli, A., Di Cesare Mannelli, L., Ghelardini, C., Calderone, V.

“…[Display omitted] Hydrogen sulfide (H2S) is a gasotransmitter deeply involved in cardiovascular homeostasis and implicated in the myocardial protection against…”
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Cadmium toxicity in animal cells by interference with essential metals by Martelli, A., Rousselet, E., Dycke, C., Bouron, A., Moulis, J.-M.

“…Cadmium is found in the environment as part of several, mainly zinc-rich, ores. It has been used in many technological applications, but biological systems…”
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Contributions of the Raf MEK ERK, PI3K PTEN Akt mTOR and Jak STAT pathways to leukemia by Steelman, L S, Abrams, S L, Whelan, J, Bertrand, F E, Ludwig, D E, Bäsecke, J, Libra, M, Stivala, F, Milella, M, Tafuri, A, Lunghi, P, Bonati, A, Martelli, A M, McCubrey, J A

“…Mutations and chromosomal translocations occur in leukemic cells that result in elevated expression or constitutive activation of various growth factor…”
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AMP-dependent kinase mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications by Grimaldi, C, Chiarini, F, Tabellini, G, Ricci, F, Tazzari, P L, Battistelli, M, Falcieri, E, Bortul, R, Melchionda, F, Iacobucci, I, Pagliaro, P, Martinelli, G, Pession, A, Barata, J T, McCubrey, J A, Martelli, A M

“…The mammalian target of rapamycin (mTOR) serine/threonine kinase is the catalytic subunit of two multi-protein complexes, referred to as mTORC1 and mTORC2…”
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Salivary IgG and IgA in newborn calves and the possible role in the assessment of passive immunity transfer by Berteselli, G V, Filipe, J, Martelli, A, Vezzaro, G, Canali, E, Dall'Ara, P

“…The transfer of immunoglobulins from the mother to newborns is widely recognized as a critical event for safeguarding offspring against potentially…”
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Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia by Simioni, C, Neri, L M, Tabellini, G, Ricci, F, Bressanin, D, Chiarini, F, Evangelisti, C, Cani, A, Tazzari, P L, Melchionda, F, Pagliaro, P, Pession, A, McCubrey, J A, Capitani, S, Martelli, A M

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder arising from T-cell progenitors. T-ALL accounts for 15% of newly diagnosed ALL…”
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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase Akt signal transduction network in human acute myelogenous leukemia blasts by TAZZARI, P. L, CAPPELLINI, A, MARTELLI, A. M, RICCI, F, EVANGELISTI, C, PAPA, V, GRAFONE, T, MARTINELLI, G, CONTE, R, COCCO, L, MCCUBREY, J. A

“…A high incidence of relapses following induction chemotherapy is a major hindrance to patient survival in acute myelogenous leukemia (AML). There is strong…”
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Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis by Bertacchini, J, Guida, M, Accordi, B, Mediani, L, Martelli, A M, Barozzi, P, Petricoin, E, Liotta, L, Milani, G, Giordan, M, Luppi, M, Forghieri, F, De Pol, A, Cocco, L, Basso, G, Marmiroli, S

“…Acute myeloid leukemia (AML) primary cells express high levels of phosphorylated Akt, a master regulator of cellular functions regarded as a promising drug…”
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Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels by Martelli, A., Testai, L., Breschi, M.C., Lawson, K., McKay, N.G., Miceli, F., Taglialatela, M., Calderone, V.

“…Hydrogen sulphide (H2S) has been recently hypothesized to be an endogenous adipocyte-derived relaxing factor, evoking vasorelaxation of conductance and…”
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