Search Results - "MARSH, K. C"

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir by KEMPF, D. J, MARSH, K. C, SUN, E, PIZZUTI, D, PLATTNER, J. J, NORBECK, D. W, LEONARD, J. M, KUMAR, G, RODRIGUES, A. D, DENISSEN, J. F, MCDONALD, E, KUKULKA, M. J, HSU, A, GRANNEMAN, G. R, BAROLDI, P. A

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys by Lynch, J J, Wilson, A W, Hernandez, L E, Nelson, R A, Marsh, K C, Cox, B F, Mittelstadt, S W

“…Background and purpose: The non‐selective β‐adrenoceptor antagonist, D,L‐sotalol (sotalol) is commonly employed as a positive control during preclinical…”
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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead by Liu, Gang, Link, J. T, Pei, Zhonghua, Reilly, Edward B, Leitza, Sandra, Nguyen, Bach, Marsh, Kennan C, Okasinski, Gregory F, von Geldern, Thomas W, Ormes, Mark, Fowler, Kerry, Gallatin, Mike

“…The interaction between leukocyte function-associated antigen-1 (LFA-1), a member of the β2-integrin family of adhesion molecules, and intracellular adhesion…”
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ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans by Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.

“…Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of symmetry-based inhibitors of the…”
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Minimization of potential hERG liability in histamine H3 receptor antagonists by Black, L. A., Liu, H., Diaz, G. J., Fox, G. B., Browman, K. E., Wetter, J., Marsh, K. C., Miller, T. R., Esbenshade, T. A., Brioni, J., Cowart, M. D.

“…Issue Title: 3. Molecular and chemical aspects of the histamine receptors…”
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3,5-Bis(trifluoromethyl)pyrazoles:  A Novel Class of NFAT Transcription Factor Regulator by Djuric, Stevan W, BaMaung, Nwe Y, Basha, Anwer, Liu, Huaqing, Luly, Jay R, Madar, David J, Sciotti, Richard J, Tu, Noah P, Wagenaar, Frank L, Wiedeman, Paul E, Zhou, Xun, Ballaron, Stephen, Bauch, Joy, Chen, Yung-Wu, Chiou, X. Grace, Fey, Thomas, Gauvin, Donna, Gubbins, Earl, Hsieh, Gin C, Marsh, Kennan C, Mollison, Karl W, Pong, Melissa, Shaughnessy, Thomas K, Sheets, Michael P, Smith, Morey, Trevillyan, James M, Warrior, Usha, Wegner, Craig D, Carter, George W

“…A series of bis(trifluoromethyl)pyrazoles (BTPs) has been found to be a novel inhibitor of cytokine production. Identified initially as inhibitors of IL-2…”
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Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418 : a novel cholinergic channel activator for memory enhancement by BUCCAFUSCO, J. J, JACKSON, W. J, TERRY, A. V, MARSH, K. C, DECKER, M. W, ARNERIC, S. P

“…ABT-418, a newly characterized centrally acting cholinergic channel activator (ChCA), was evaluated for its ability to improve performance in a delayed…”
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Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy by Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W

“…The structure−activity studies leading to the potent and clinically efficacious HIV protease inhibitor ritonavir are described. Beginning with the moderately…”
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Relation between procedural activated coagulation time and outcome after percutaneous transluminal coronary angioplasty by Ferguson, James J., Dougherty, Kathryn G., Gaos, Carlos M., Bush, Howard S., Marsh, Kathryn C., Leachman, D.Richard

“…Objectives. The purpose of this study was to determine whether a low procedural activated coagulation time is associated with a high rate of in-hospital…”
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Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-c]pyridines with Fine-Tuning at C-2 Carbamides by Zhu, Gui-Dong, Arendsen, David L, Gunawardana, Indrani W, Boyd, Steven A, Stewart, Andrew O, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Schaefer, Verlyn, Meuth, Joseph, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Gallatin, W. Michael, Okasinski, Gregory F

“…The elevated expression of cell adhesion molecules (CAMs) on the lumenal surface of vascular endothelial cells is a critical early event in the complex…”
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Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol by Kempf, Dale J, Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C, Bryant, Pamela

“…The structure-activity relationships in two series of novel, symmetry-based inhibitors of HIV protease, the enzyme responsible for maturation of the human…”
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Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease by Kempf, D J, Marsh, K C, Paul, D A, Knigge, M F, Norbeck, D W, Kohlbrenner, W E, Codacovi, L, Vasavanonda, S, Bryant, P, Wang, X C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression by Stewart, Andrew O, Bhatia, Pramila A, McCarty, Catherine M, Patel, Meena V, Staeger, Michael A, Arendsen, David L, Gunawardana, Indrani W, Melcher, Laura M, Zhu, Gui-Dong, Boyd, Steven A, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Lartey, Kraig, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Wisdom, Wendy, Meyer, Joey, Gallatin, W. Michael, Okasinski, Gregory F

“…A critical early event in the inflammatory cascade is the induced expression of cell adhesion molecules on the lumenal surface of vascular endothelial cells…”
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2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ETA Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722 by Winn, Martin, von Geldern, Thomas W, Opgenorth, Terry J, Jae, Hwan-Soo, Tasker, Andrew S, Boyd, Steven A, Kester, Jeffrey A, Mantei, Robert A, Bal, Radhika, Sorensen, Bryan K, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Novosad, Eugene I, Hernandez, Lisa, Marsh, Kennan C

“…We have discovered a novel class of endothelin (ET) receptor antagonists through pharmacophore analysis of the existing non-peptide ET antagonists. On the…”
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Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides by Pei, Zhonghua, Xin, Zhili, Liu, Gang, Li, Yihong, Reilly, Edward B, Lubbers, Nathan L, Huth, Jeffery R, Link, James T, von Geldern, Thomas W, Cox, Bryan F, Leitza, Sandra, Gao, Yi, Marsh, Kennan C, DeVries, Peter, Okasinski, Greg F

“…The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on…”
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Analytical method development for the simultaneous quantitation of dexmedetomidine and three potential metabolites in plasma by Hui, Y.-H., Marsh, K.C., Menacherry, S.

“…Dexmedetomidine, a novel α 2-adrenergic receptor agonist, is being developed as an anesthetic adjunct for perioperative use. An assay method has been developed…”
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Metabolism and disposition of clarithromycin in man by Ferrero, J L, Bopp, B A, Marsh, K C, Quigley, S C, Johnson, M J, Anderson, D J, Lamm, J E, Tolman, K G, Sanders, S W, Cavanaugh, J H

“…The metabolic fate and pharmacokinetics of clarithromycin following a single 250- or 1200-mg oral dose of 14C-clarithromycin were studied in six healthy adult…”
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Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 2. Sulfonamide-Based ETA/ETB Mixed Antagonists by Jae, Hwan-Soo, Winn, Martin, Dixon, Douglas B, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J, von Geldern, Thomas W

“…When the N,N-dialkylacetamide side chain of the highly ETA-selective endothelin antagonist ABT-627 (1;…”
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Thrombospondin-1 Mimetic Peptide Inhibitors of Angiogenesis and Tumor Growth:  Design, Synthesis, and Optimization of Pharmacokinetics and Biological Activities by Haviv, Fortuna, Bradley, Michael F, Kalvin, Douglas M, Schneider, Andrew J, Davidson, Donald J, Majest, Sandra M, McKay, Laura M, Haskell, Catherine J, Bell, Randy L, Nguyen, Bach, Marsh, Kennan C, Surber, Bruce W, Uchic, John T, Ferrero, James, Wang, Yi-Chun, Leal, Juan, Record, Rae D, Hodde, Jason, Badylak, Stephen F, Lesniewski, Richard R, Henkin, Jack

“…The heptapeptide 1, NAc-Gly-Val-DIle-Thr-Arg-Ile-ArgNHEt, a structurally modified fragment derived from the second type-1 repeat of thrombospondin-1 (TSP-1),…”
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Pulmonary delivery of a dopamine D-1 agonist, ABT-431, in dogs and humans by Zheng, Yuqun, C. Marsh, Kennan, J. Bertz, Richard, El-Shourbagy, Tawakol, L. Adjei, Akwete

“…The purpose of this study was to evaluate the feasibility of intrapulmonary delivery of ABT-431, a selective D1 receptor agonist. Following intratracheal…”
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