Search Results - "MAROUDAS, Alice"

Articular Cartilage Proteoglycans As Boundary Lubricants: Structure and Frictional Interaction of Surface-Attached Hyaluronan and Hyaluronan–Aggrecan Complexes by Seror, Jasmine, Merkher, Yulia, Kampf, Nir, Collinson, Lisa, Day, Anthony J, Maroudas, Alice, Klein, Jacob

“…Mammalian synovial joints are extremely efficient lubrication systems reaching friction coefficient μ as low as 0.001 at high pressures (up to 100 atm) and…”
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Normal and Shear Interactions between Hyaluronan–Aggrecan Complexes Mimicking Possible Boundary Lubricants in Articular Cartilage in Synovial Joints by Seror, Jasmine, Merkher, Yulia, Kampf, Nir, Collinson, Lisa, Day, Anthony J, Maroudas, Alice, Klein, Jacob

“…Using a surface force balance, normal and shear interactions have been measured between two atomically smooth surfaces coated with hyaluronan (HA), and with…”
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Collagen Turnover in Normal and Degenerate Human Intervertebral Discs as Determined by the Racemization of Aspartic Acid by Sivan, Sarit-Sara, Wachtel, Ellen, Tsitron, Eve, Sakkee, Nico, van der Ham, Frits, DeGroot, Jeroen, Roberts, Sally, Maroudas, Alice

“…Knowledge of rates of protein turnover is important for a quantitative understanding of tissue synthesis and catabolism. In this work, we have used the…”
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Aggrecan Turnover in Human Intervertebral Disc as Determined by the Racemization of Aspartic Acid by Sivan, Sarit S., Tsitron, Eve, Wachtel, Ellen, Roughley, Peter J., Sakkee, Nico, van der Ham, Frits, DeGroot, Jeroen, Roberts, Sally, Maroudas, Alice

“…We have used the racemization of aspartic acid as a marker for the “molecular age” of aggrecan components of the human intervertebral disc matrix (aggregating…”
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Mechanical Properties of the Collagen Network in Human Articular Cartilage as Measured by Osmotic Stress Technique by Basser, Peter J., Schneiderman, Rosa, Bank, Ruud A., Wachtel, Ellen, Maroudas, Alice

“…We have used an isotropic osmotic stress technique to assess the swelling pressures of human articular cartilage over a wide range of hydrations in order to…”
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Human intervertebral disc cells promote nerve growth over substrata of human intervertebral disc aggrecan by JOHNSON, William E. B, SIVAN, Sarit, WRIGHT, Karina T, EISENSTEIN, Stephen M, MAROUDAS, Alice, ROBERTS, Sally

“…Coculture assays of the migration and interaction of human intervertebral disc cells and chick sensory nerves on alternate substrata of collagen and aggrecan…”
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Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: the use of pentosidine levels as a quantitative measure of protein turnover by Verzijl, Nicole, DeGroot, Jeroen, Bank, Ruud A., Bayliss, Michael T., Bijlsma, Johannes W.J., Lafeber, Floris P.J.G., Maroudas, Alice, TeKoppele, Johan M.

“…During aging, non-enzymatic glycation results in the formation and accumulation of the advanced glycation endproduct pentosidine in long-lived proteins, such…”
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A simplified measurement of degraded collagen in tissues: Application in healthy, fibrillated and osteoarthritic cartilage by Bank, Ruud A., Krikken, Marianne, Beekman, Bob, Stoop, Reinout, Maroudas, Alice, Lafebers, Floris P.J.G., Te Koppele, Johan M.

“…Intact triple helical collagen molecules are highly resistant to proteolytic enzymes, whereas degraded (unwound) collagen is easily digested. This fact was…”
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Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc by Sivan, Sarit Sara, Hayes, Anthony J., Wachtel, Ellen, Caterson, Bruce, Merkher, Yulia, Maroudas, Alice, Brown, Sharon, Roberts, Sally

“…Background The intervertebral disc (IVD) is a complex cartilaginous structure which functions to resist biomechanical loads during spinal movement. It consists…”
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Magnetic resonance imaging of cartilage glycosaminoglycan: Basic principles, imaging technique, and clinical applications by Gray, Martha L., Burstein, Deborah, Kim, Young-Jo, Maroudas, Alice

“…Many new therapeutic strategies have been and are being developed to prevent, correct, or slow the progression of osteoarthritis. Our ability to evaluate the…”
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Liposomes Act as Effective Biolubricants for Friction Reduction in Human Synovial Joints by Sivan, Sarit, Schroeder, Avi, Verberne, Gabi, Merkher, Yulia, Diminsky, Dvora, Priev, Aba, Maroudas, Alice, Halperin, Gregory, Nitzan, Dorrit, Etsion, Izhak, Barenholz, Yechezkel

“…Phospholipids (PL) form the matrix of biological membranes and of the lipoprotein envelope monolayer, and are responsible for many of the unique…”
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Age-related accumulation of pentosidine in aggrecan and collagen from normal and degenerate human intervertebral discs by Sivan, Sarit Sara, Tsitron, Eve, Wachtel, Ellen, Roughley, Peter, Sakkee, Nico, van der Ham, Frits, Degroot, Jeroen, Maroudas, Alice

“…During aging and degeneration, many changes occur in the structure and composition of human cartilaginous tissues, which include the accumulation of the AGE…”
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Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis by Verzijl, Nicole, DeGroot, Jeroen, Zaken, Chaya Ben, Braun‐Benjamin, Orit, Maroudas, Alice, Bank, Ruud A., Mizrahi, Joe, Schalkwijk, Casper G., Thorpe, Suzanne R., Baynes, John W., Bijlsma, Johannes W. J., Lafeber, Floris P. J. G., TeKoppele, Johan M.

“…Objective Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end…”
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Correlation of swelling pressure and intrafibrillar water in young and aged human intervertebral discs by Sivan, Sarit, Merkher, Yulia, Wachtel, Ellen, Ehrlich, Shlomit, Maroudas, Alice

“…Fluid balance in the intervertebral disc under applied load is determined primarily by its swelling pressure, that is, the external pressure at which it…”
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Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid by Sivan, Sarit-Sara, Van El, Benno, Merkher, Yulia, Schmelzer, Christian E.H., Zuurmond, Anne-Marie, Heinz, Andrea, Wachtel, Ellen, Varga, Peter-Paul, Lazary, Aron, Brayda-Bruno, Marco, Maroudas, Alice

“…Aging and degeneration of human intervertebral disc (IVD) are associated with biochemical changes, including racemization and glycation. These changes can only…”
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A needle micro-osmometer for determination of glycosaminoglycan concentration in excised nucleus pulposus tissue by Sivan, Sarit Sara, Merkher, Yulia, Wachtel, Ellen, Urban, Jill P. G., Lazary, Aron, Maroudas, Alice

“…Purpose Aggrecan is one of the major macromolecular components of the intervertebral disc (IVD) and its loss is an early sign of degeneration. Restoration of…”
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A theoretical study of the distribution of insulin-like growth factor in human articular cartilage by Barta, Efrath, Maroudas, Alice

“…We present a mathematical simulation which integrates the mechanisms that are currently believed to govern the concentration of the growth factor, IGF1, in…”
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Are disc pressure, stress, and osmolarity affected by intra- and extrafibrillar fluid exchange? by Schroeder, Yvonne, Sivan, Sarit, Wilson, Wouter, Merkher, Yulia, Huyghe, Jacques M., Maroudas, Alice, Baaijens, Frank P.T.

“…Because extrafibrillar water content dictates extrafibrillar osmolarity, we aimed to determine the influence of intra‐ and extrafibrillar fluid exchange on…”
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Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage by Bank, R A, Bayliss, M T, Lafeber, F P, Maroudas, A, Tekoppele, J M

“…A biomechanical failure of the collagen network is postulated in many hypotheses of the development of osteoarthritis with advancing age. Here we investigate…”
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Diffusion and partition of solutes in cartilage under static load by Nimer, Emad, Schneiderman, Rosa, Maroudas, Alice

“…We describe experimental apparatus, methodology and mathematical algorithms to measure diffusion and partition for typical small ionic solutes and inulin (a…”
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