Search Results - "MARKOWITZ, M. Kristine"

Discovery of a Potent, Non-peptide Bradykinin B1 Receptor Antagonist by Su, Dai-Shi, Markowitz, M. Kristine, DiPardo, Robert M, Murphy, Kathy L, Harrell, C. Meacham, O'Malley, Stacy S, Ransom, Richard W, Chang, Raymond S. L, Ha, Sookhee, Hess, Fred J, Pettibone, Douglas J, Mason, Glenn S, Boyce, Susan, Freidinger, Roger M, Bock, Mark G

“…Bradykinin (BK) plays an important role in the pathophysiological processes accompanying pain and inflammation. Selective bradykinin B1 receptor antagonists…”
Get full text

Potent bradykinin B1 receptor antagonists : 4-Substituted phenyl cyclohexanes by SU, Dai-Shi, LIM, John L, PETTIBONE, Douglas J, CUYUE TANG, PRUEKSARITANONT, Thomayant, FREIDINGER, Roger M, BOCK, Mark G, KRISTINE MARKOWITZ, M, WAN, Bang-Lin, MURYHY, Kathy L, REISS, Duane R, MEACHAM HARRELL, C, O'MALLEY, Stacy S, RANSOM, Rick W, CHANG, Raymond S. L

“…Selective bradykinin (BK) B(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the…”
Get full text

Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model by Hess, J Fred, Ransom, Richard W, Zeng, Zhizhen, Chang, Raymond S L, Hey, Patricia J, Warren, Lee, Harrell, Charles M, Murphy, Kathryn L, Chen, Tsing-Bau, Miller, Patricia J, Lis, Edward, Reiss, Duane, Gibson, Raymond E, Markowitz, M Kristine, DiPardo, Robert M, Su, Dai-Shi, Bock, Mark G, Gould, Robert J, Pettibone, Douglas J

“…Antagonists of the B1 bradykinin receptor (B1R) offer the promise of novel therapeutic agents for the treatment of inflammatory and neuropathic pain. However,…”
Get more information

Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1 by Ha, Sookhee N., Hey, Pat J., Ransom, Rick W., Harrell, C. Meacham, Murphy, Kathryn L., Chang, Ray, Chen, Tsing-Bau, Su, Dai-Shi, Markowitz, M. Kristine, Bock, Mark G., Freidinger, Roger M., Hess, Fred J.

“…We report the first homology model of human bradykinin receptor B1 generated from the crystal structure of bovine rhodopsin as a template. Using an automated…”
Get full text

Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist by RANSOM, Richard W, HARRELL, Charles M, SU, Dai-Shi, MARKOWITZ, M. Kristine, WALLACE, Michael A, RAAB, Conrad E, JONES, Allen N, DEAN, Dennis C, PETTIBONE, Douglas J, FREIDINGER, Roger M, BOCK, Mark G, REISS, Duane R, MURPHY, Kathryn L, CHANG, Raymond S. L, HESS, J. Fred, MILLER, Patricia J, O'MALLEY, Stacey S, HEY, Pat J, KUNAPULI, Priya

“…Compound A (N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]-2-[(2R)-1-(2-napthylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]acetamide) is a member of…”
Get full text

Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies by SU, Dai-Shi, MARKOWITZ, M. Kristine, WALLACE, Michael A, RAAB, Conrad E, DEAN, Dennis C, PETTIBONE, Douglas J, FREIDINGER, Roger M, BOCK, Mark G, MURPHY, Kathy L, WAN, Bang-Lin, ZRADA, Matthew M, HARRELL, C. Meacham, O'MALLEY, Stacy S, HESS, J. Fred, RANSOM, Rick W, CHANG, Ray S

“…We have developed an efficient and selective radioligand, the [35S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor occupancy assay in…”
Get full text

Discovery of a Potent, Non-peptide Bradykinin B 1 Receptor Antagonist by Su, Dai-Shi, Markowitz, M. Kristine, DiPardo, Robert M., Murphy, Kathy L., Harrell, C. Meacham, O'Malley, Stacy S., Ransom, Richard W., Chang, Raymond S. L., Ha, Sookhee, Hess, Fred J., Pettibone, Douglas J., Mason, Glenn S., Boyce, Susan, Freidinger, Roger M., Bock, Mark G.

Get full text

Potent bradykinin B 1 receptor antagonists: 4-Substituted phenyl cyclohexanes by Su, Dai-Shi, Lim, John L., Markowitz, M. Kristine, Wan, Bang-Lin, Murphy, Kathy L., Reiss, Duane R., Harrell, C. Meacham, O’Malley, Stacy S., Ransom, Rick W., Chang, Raymond S.L., Pettibone, Douglas J., Tang, Cuyue, Prueksaritanont, Thomayant, Freidinger, Roger M., Bock, Mark G.

“…4-Substituted phenyl cyclohexanes were identified as alternative isosteres for the biphenyl moiety of the lead compound 1. The syntheses, SAR optimization, and…”
Get full text

Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B 1 receptor antagonist by Ransom, Richard W., Harrell, Charles M., Reiss, Duane R., Murphy, Kathryn L., Chang, Raymond S.L., Hess, J. Fred, Miller, Patricia J., O'Malley, Stacey S., Hey, Pat J., Kunapuli, Priya, Su, Dai-Shi, Markowitz, M. Kristine, Wallace, Michael A., Raab, Conrad E., Jones, Allen N., Dean, Dennis C., Pettibone, Douglas J., Freidinger, Roger M., Bock, Mark G.

“…Compound A ( N-{2-[4-(4,5-dihydro-1 H-imidazol-2-yl)phenyl]ethyl}-2-[(2 R)-1-(2-napthylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]acetamide) is a member…”
Get full text

Development of an efficient and selective radioligand for bradykinin B 1 receptor occupancy studies by Su, Dai-Shi, Markowitz, M. Kristine, Murphy, Kathy L., Wan, Bang-Lin, Zrada, Matthew M., Harrell, C. Meacham, O’Malley, Stacy S., Hess, J. Fred, Ransom, Rick W., Chang, Ray S., Wallace, Michael A., Raab, Conrad E., Dean, Dennis C., Pettibone, Douglas J., Freidinger, Roger M., Bock, Mark G.

“…[Display omitted] We have developed an efficient and selective radioligand, the [ 35S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor…”
Get full text