Search Results - "MARKGRAF, G"

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition by Fell, Matthew J, Mirescu, Christian, Basu, Kallol, Cheewatrakoolpong, Boonlert, DeMong, Duane E, Ellis, J Michael, Hyde, Lynn A, Lin, Yinghui, Markgraf, Carrie G, Mei, Hong, Miller, Michael, Poulet, Frederique M, Scott, Jack D, Smith, Michelle D, Yin, Zhizhang, Zhou, Xiaoping, Parker, Eric M, Kennedy, Matthew E, Morrow, John A

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of familial and sporadic Parkinson's disease (PD). That the most…”
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Treatment window for hypothermia in brain injury by MARKGRAF, Carrie G, CLIFTON, Guy L, MOODY, Melanie R

“…The goal of this study was to evaluate the therapeutic window for hypothermia treatment following experimental brain injury by measuring edema formation and…”
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Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats by Markgraf, C G, Velayo, N L, Johnson, M P, McCarty, D R, Medhi, S, Koehl, J R, Chmielewski, P A, Linnik, M D

“…Stroke patients often experience a significant temporal delay between the onset of ischemia and the time to initiation of therapy. Thus, there is a need for…”
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Abuse liability assessment for biologic drugs – All molecules are not created equal by de Zafra, Christina L. Zuch, Markgraf, Carrie G., Compton, David R., Hudzik, Thomas J.

“…The development of novel drug candidates involves the thorough evaluation of potential efficacy and safety. To facilitate the safety assessment in light of…”
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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity by Bryce, Dianne K, Ware, Chris M, Woodhouse, Janice D, Ciaccio, Paul J, Ellis, J Michael, Hegde, Laxminarayan G, Kuruvilla, Sabu, Maddess, Matthew L, Markgraf, Carrie G, Otte, Karin M, Poulet, Frederique M, Timmins, Lauren M, Kennedy, Matthew E, Fell, Matthew J

“…Gain-of-function mutations in leucine-rich kinase 2 (LRRK2) are associated with increased incidence of Parkinson disease (PD); thus, pharmacological inhibition…”
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Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats by Markgraf, C G, Green, E J, Hurwitz, B E, Morikawa, E, Dietrich, W D, McCabe, P M, Ginsberg, M D, Schneiderman, N

“…Rats were subjected to either right proximal middle cerebral artery (MCA) occlusion or sham operation, and examined for an extended period on a battery of…”
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Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery by Pugsley, Michael K., Bekele, Bisrat, Griessel, Helene, de Korte, Tessa, Authier, Simon, Grobler, Anne F., Markgraf, Carrie G., Curtis, Michael J.

“…This editorial summarizes the content of the current themed issue of J Pharm Tox Methods derived from the 2019 Annual Safety Pharmacology Society (SPS) meeting…”
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Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat by Dixon, C E, Markgraf, C G, Angileri, F, Pike, B R, Wolfson, B, Newcomb, J K, Bismar, M M, Blanco, A J, Clifton, G L, Hayes, R L

“…A number of experimental studies have reported that moderate hypothermia can produce significant protection against behavioral deficits and/or…”
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Assessment of seizure liability of Org 306039, a 5-HT2c agonist, using hippocampal brain slice and rodent EEG telemetry by Markgraf, Carrie G., DeBoer, Erik, Zhai, Jin, Cornelius, Lara, Zhou, Ying Ying, MacSweeney, Cliona

“…Evaluation of the seizure potential for a CNS-targeted pharmaceutical compound before it is administered to humans is an important part of development. The…”
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Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and wistar rats by MARKGRAF, C. G, KRAYDIEH, S, PRADO, R, WATSON, B. D, DALTON DIETRICH, W, GINSBERG, M. D, GARCIA, J. H

“…We have developed a minimally invasive model of photothrombotic occlusion of the distal middle cerebral artery in rats and have evaluated the patterns and…”
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An overview of the safety pharmacology society strategic plan by Pugsley, M.K., Authier, S., Koerner, J.E., Redfern, W.S., Markgraf, C.G., Brabham, T., Correll, K., Soloviev, M.V., Botchway, A., Engwall, M., Traebert, M., Valentin, J.-P., Mow, T.J., Greiter-Wilke, A., Leishman, D.J., Vargas, H.M.

“…Safety Pharmacology studies are conducted to characterize the confidence by which biologically active new chemical entities (NCE) may be anticipated as safe…”
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Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats by Green, E J, Dietrich, W D, van Dijk, F, Busto, R, Markgraf, C G, McCabe, P M, Ginsberg, M D, Schneiderman, N

“…The present experiments were designed to assess whether brain hypothermia can reduce the behavioral and histopathological deficits associated with global…”
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Comparison of methods for analysis of functional observation battery (FOB) data by Markgraf, Carrie G., Cirino, Maria, Meredith, John

“…Introduction: Different methods for the analysis of behavioral observation data were compared to evaluate how the interpretation of a data set may depend on…”
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The Safety Pharmacology Society salary survey by Pugsley, Michael K., Authier, Simon, Brabham, Tiffini, Soloviev, Maxim, Markgraf, Carrie G., Correll, Krystle, Traebert, Martin, Greiter-Wilke, Andrea, Valentin, Jean-Pierre, Vargas, Hugo, Botchway, Alfred, Leishman, Derek J., Curtis, Michael J.

“…Safety pharmacology is a growing discipline with scientists broadly distributed across international geographical regions. This electronic salary survey is the…”
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Injury severity and sensitivity to treatment after controlled cortical impact in rats by Markgraf, C G, Clifton, G L, Aguirre, M, Chaney, S F, Knox-Du Bois, C, Kennon, K, Verma, N

“…We sought to determine sensitivity of the cortical impact injury model of traumatic brain injury (TBI) to severity of injury and to treatment. We examined the…”
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Magnetic resonance imaging assessment of the ventricular system in the brains of adult and juvenile beagle dogs treated with posaconazole IV Solution by Hines, C.D.G., Song, X., Kuruvilla, S., Farris, G., Markgraf, C.G.

“…Noxafil® (posaconazole; POS) is a potent, selective triazole antifungal approved for use in adults as an oral suspension, oral tablet and intravenous (IV)…”
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Recovery of sensorimotor function after distal middle cerebral artery photothrombotic occlusion in rats by Markgraf, C G, Green, E J, Watson, B, McCabe, P M, Schneiderman, N, Dietrich, W D, Ginsberg, M D

“…The purpose of the present study was to delineate the behavioral correlates of focal thrombotic occlusion of the distal middle cerebral artery in rats and to…”
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Behavioral Recovery Patterns in Rats Receiving the NMDA Receptor Antagonist MDL 100,453 Immediately Post-Stroke by Markgraf, Carrie G, Johnson, Michael P, Braun, Don L, Bickers, Mary V

“…Rats were given MDL 100,453 ((R)-4-Oxo-5-phosphononorvaline) in a pre-determined neuroprotective dose consisting of a bolus of 24.8 mg/kg followed by an…”
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MDL 101,002, a free radical spin trap, is efficacious in permanent and transient focal ischemia models by Johnson, Michael P, McCarty, Debbie R, Velayo, Nelson L, Markgraf, Carrie G, Chmielewski, Paula A, Ficorilli, James V, Cheng, Hsien C, Thomas, Craig E

“…The present work describes the neuroprotective effects of the free radical spin trap, MDL 101,002, in models of permanent and transient focal ischemia…”
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Glutamate antagonist MK-801 attenuates incomplete but not complete infarction in thrombotic distal middle cerebral artery occlusion in Wistar rats by Yao, H, Markgraf, C G, Dietrich, W D, Prado, R, Watson, B D, Ginsberg, M D

“…The purpose of this study was to investigate the effects of a non-competitive N-methyl-D-aspartate antagonist, MK-801, on incomplete infarction (selective…”
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