Search Results - "MARK, Manuel"

Function of retinoid nuclear receptors : Lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis by MARK, Manuel, GHYSELINCK, Norbert B, CHAMBON, Pierre

“…Retinoic acid (RA) is involved in vertebrate morphogenesis, growth, cellular differentiation, and tissue homeostasis. The use of in vitro systems initially led…”
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Prey-size plastics are invading larval fish nurseries by Gove, Jamison M., Whitney, Jonathan L., McManus, Margaret A., Lecky, Joey, Carvalho, Felipe C., Lynch, Jennifer M., Li, Jiwei, Neubauer, Philipp, Smith, Katharine A., Phipps, Jana E., Kobayashi, Donald R., Balagso, Karla B., Contreras, Emily A., Manuel, Mark E., Merrifield, Mark A., Polovina, Jeffrey J., Asner, Gregory P., Maynard, Jeffrey A., Williams, Gareth J.

“…Life for many of the world’s marine fish begins at the ocean surface. Ocean conditions dictate food availability and govern survivorship, yet little is known…”
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Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERβ-null mutant by Antal, Maria Cristina, Krust, Andrée, Chambon, Pierre, Mark, Manuel

“…Estrogen signaling is mediated by estrogen receptors α (ERα) and β (ERβ). Although a consensus has now been reached concerning many physiological functions of…”
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Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells by Liszt, Kathrin Ingrid, Ley, Jakob Peter, Lieder, Barbara, Behrens, Maik, Stöger, Verena, Reiner, Angelika, Hochkogler, Christina Maria, Köck, Elke, Marchiori, Alessandro, Hans, Joachim, Widder, Sabine, Krammer, Gerhard, Sanger, Gareth John, Somoza, Mark Manuel, Meyerhof, Wolfgang, Somoza, Veronika

“…Caffeine, generally known as a stimulant of gastric acid secretion (GAS), is a bitter-tasting compound that activates several taste type 2 bitter receptors…”
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Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis by Raverdeau, Mathilde, Gely-Pernot, Aurore, Féret, Betty, Dennefeld, Christine, Benoit, Gérard, Davidson, Irwin, Chambon, Pierre, Mark, Manuel, Ghyselinck, Norbert B

“…Direct evidence for a role of endogenous retinoic acid (RA), the active metabolite of vitamin A in the initial differentiation and meiotic entry of…”
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Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium by Teletin, Marius, Vernet, Nadège, Yu, Jianshi, Klopfenstein, Muriel, Jones, Jace W, Féret, Betty, Kane, Maureen A, Ghyselinck, Norbert B, Mark, Manuel

“…In mammals, all- retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present in both Sertoli…”
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Function of retinoic acid receptors during embryonic development by Mark, Manuel, Ghyselinck, Norbert B, Chambon, Pierre

“…Retinoids, the active metabolites of vitamin A, regulate complex gene networks involved in vertebrate morphogenesis, growth, cellular differentiation and…”
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Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma by Herquel, Benjamin, Ouararhni, Khalid, Khetchoumian, Konstantin, Ignat, Mihaela, Teletin, Marius, Mark, Manuel, Béchade, Guillaume, Van Dorsselaer, Alain, Sanglier-Cianférani, Sarah, Hamiche, Ali, Cammas, Florence, Davidson, Irwin, Losson, Régine

“…TRIM24 (TIF1α), TRIM28 (TIF1β), and TRIM33 (TIF1γ) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct…”
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Roles of Retinoic Acid in Germ Cell Differentiation by Teletin, Marius, Vernet, Nadège, Ghyselinck, Norbert B, Mark, Manuel

“…The modalities of gametogenesis differ markedly between sexes. Female are born with a definitive reserve of oocytes whose size is crucial to ensure fertility…”
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Spermatogonia Differentiation Requires Retinoic Acid Receptor γ by Gely-Pernot, Aurore, Raverdeau, Mathilde, Célébi, Catherine, Dennefeld, Christine, Feret, Betty, Klopfenstein, Muriel, Yoshida, Shosei, Ghyselinck, Norbert B, Mark, Manuel

“…Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three…”
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Bitter-Tasting Amino Acids l‑Arginine and l‑Isoleucine Differentially Regulate Proton Secretion via T2R1 Signaling in Human Parietal Cells in Culture by Stoeger, Verena, Holik, Ann-Katrin, Hölz, Kathrin, Dingjan, Tamir, Hans, Joachim, Ley, Jakob P, Krammer, Gerhard E, Niv, Masha Y, Somoza, Mark Manuel, Somoza, Veronika

“…This study aimed at identifying whether the bitter-tasting amino acids l-arginine (l-ARG) and l-isoleucine (l-ILE) differentially regulate mechanisms of…”
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Reproduction Function in Male Patients With Bardet Biedl Syndrome by Isabelle, Koscinski, Manuel, Mark, Nadia, Messaddeq, Jean-Jacques, Braun, Catherine, Celebi, Jean, Muller, Anna, Zinetti-Bertschy, Nathalie, Goetz, Hélène, Dollfus, Sylvie, Rossignol

“…Abstract Purpose Bardet-Biedl syndrome (BBS) is a ciliopathy with a wide spectrum of symptoms due to primary cilia dysfunction, including genitourinary…”
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Retinoic Acid Metabolism and Signaling Pathways in the Adult and Developing Mouse Testis by Vernet, Nadège, Dennefeld, Christine, Rochette-Egly, Cécile, Oulad-Abdelghani, Mustapha, Chambon, Pierre, Ghyselinck, Norbert B, Mark, Manuel

“…As a first step in investigating the role of retinoic acid (RA) in mouse testis, we analyzed the distribution pattern of the enzymes involved in vitamin A…”
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Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation by Mark, Manuel, Teletin, Marius, Vernet, Nadège, Ghyselinck, Norbert B.

“…All-trans retinoic acid (atRA), the active metabolite of vitamin A, plays critical functions in spermatogenesis, a complex, highly organized and regulated…”
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Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor by Gely-Pernot, Aurore, Raverdeau, Mathilde, Teletin, Marius, Vernet, Nadège, Féret, Betty, Klopfenstein, Muriel, Dennefeld, Christine, Davidson, Irwin, Benoit, Gérard, Mark, Manuel, Ghyselinck, Norbert B

“…All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism of action remains elusive. To address this question, we…”
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Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression by Tarabay, Yara, Achour, Mayada, Teletin, Marius, Ye, Tao, Teissandier, Aurélie, Mark, Manuel, Bourc'his, Déborah, Viville, Stéphane

“…genes are mammalian specific and duplicated to give and in some species, such as the mouse and rat. It has been demonstrated that mutant males display a…”
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STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation by Mark, Manuel, Jacobs, Hugues, Oulad-Abdelghani, Mustapha, Dennefeld, Christine, Féret, Betty, Vernet, Nadège, Codreanu, Carmen-Alina, Chambon, Pierre, Ghyselinck, Norbert B

“…We analysed the phenotypic outcome of a Stra8-null mutation on male meiosis. Because the mutant spermatocytes (1) underwent premeiotic DNA replication, (2)…”
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Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells by Vernet, Nadège, Dennefeld, Christine, Guillou, Florian, Chambon, Pierre, Ghyselinck, Norbert B, Mark, Manuel

“…Sertoli cells (SC) are instrumental to stem spermatogonia differentiation, a process that critically depends on retinoic acid (RA). We show here that selective…”
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Timeline of Developmental Defects Generated upon Genetic Inhibition of the Retinoic Acid Receptor Signaling Pathway by Teletin, Marius, Mark, Manuel, Wendling, Olivia, Vernet, Nadège, Féret, Betty, Klopfenstein, Muriel, Herault, Yann, Ghyselinck, Norbert B

“…It has been established for almost 30 years that the retinoic acid receptor (RAR) signalling pathway plays essential roles in the morphogenesis of a large…”
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Retinoic Acid Receptor Alpha Is Essential in Postnatal Sertoli Cells but Not in Germ Cells by Condrea, Diana, Souali-Crespo, Sirine, Féret, Betty, Klopfenstein, Muriel, Faisan, Sylvain, Mark, Manuel, Ghyselinck, Norbert B, Vernet, Nadège

“…Retinoic acid signaling is indispensable for the completion of spermatogenesis. It is known that loss of retinoic acid nuclear receptor alpha (RARA) induces…”
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