Search Results - "MARK, Brian L"

Biochemical Insights into Imipenem Collateral Susceptibility Driven by ampC Mutations Conferring Ceftolozane/Tazobactam Resistance in Pseudomonas aeruginosa by Cabot, Gabriel, Kim, Kihun, Mark, Brian L, Oliver, Antonio, Khajehpour, Mazdak

“…Several Pseudomonas aeruginosa AmpC mutants have emerged that exhibit enhanced activity against ceftazidime and ceftolozane, while also evading inhibition by…”
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Viral deubiquitinating proteases and the promising strategies of their inhibition by van Vliet, Vera J.E., De Silva, Anuradha, Mark, Brian L., Kikkert, Marjolein

“…•Viral proteases with deubiquitinating activity suggest an antiviral immune evasive effect.•Antiviral strategies against viral proteases of nidoviruses have…”
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Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression by Bailey-Elkin, Ben A., Knaap, Robert C.M., Johnson, Garrett G., Dalebout, Tim J., Ninaber, Dennis K., van Kasteren, Puck B., Bredenbeek, Peter J., Snijder, Eric J., Kikkert, Marjolein, Mark, Brian L.

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging human pathogen that was first isolated in 2012. MERS-CoV replication depends in…”
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Transactivation of programmed ribosomal frameshifting by a viral protein by Li, Yanhua, Treffers, Emmely E, Napthine, Sawsan, Tas, Ali, Zhu, Longchao, Sun, Zhi, Bell, Susanne, Mark, Brian L, van Veelen, Peter A, van Hemert, Martijn J, Firth, Andrew E, Brierley, Ian, Snijder, Eric J, Fang, Ying

“…Programmed −1 ribosomal frameshifting (−1 PRF) is a widely used translational mechanism facilitating the expression of two polypeptides from a single mRNA…”
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Uninterrupted Maximum Flow on Signalized Traffic Networks by Friedman, Melvin H, Mark, Brian L, Gartner, Nathan H

“…This paper describes a traffic signal control strategy that allows motorists who travel at a recommended speed on suburban arterial two-way roads with a common…”
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Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein by Tchesnokov, Egor P, Bailey-Elkin, Ben A, Mark, Brian L, Götte, Matthias

“…Background The Crimean-Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health…”
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Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells by van Kasteren, Puck B, Bailey-Elkin, Ben A, James, Terrence W, Ninaber, Dennis K, Beugeling, Corrine, Khajehpour, Mazdak, Snijder, Eric J, Mark, Brian L, Kikkert, Marjolein

“…Protein ubiquitination regulates important innate immune responses. The discovery of viruses encoding deubiquitinating enzymes (DUBs) suggests they remove…”
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Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis by Bailey-Elkin, Ben A, Knaap, Robert C M, De Silva, Anuradha, Boekhoud, Ilse M, Mous, Sandra, van Vught, Niek, Khajehpour, Mazdak, van den Born, Erwin, Kikkert, Marjolein, Mark, Brian L

“…Deubiquitination of cellular substrates by viral proteases is a mechanism used to interfere with host cellular signaling processes, shared between members of…”
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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site by van Vliet, Vera J E, Huynh, Nhan, Palà, Judith, Patel, Ankoor, Singer, Alex, Slater, Cole, Chung, Jacky, van Huizen, Mariska, Teyra, Joan, Miersch, Shane, Luu, Gia-Khanh, Ye, Wei, Sharma, Nitin, Ganaie, Safder S, Russell, Raquel, Chen, Chao, Maynard, Mindy, Amarasinghe, Gaya K, Mark, Brian L, Kikkert, Marjolein, Sidhu, Sachdev S

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of…”
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Delay Network Tomography Using a Partially Observable Bivariate Markov Chain by Etemadi Rad, Neshat, Ephraim, Yariv, Mark, Brian L.

“…Estimation of link delay densities in a computer network, from source-destination delay measurements, is of great importance in analyzing and improving the…”
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Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants by Zhang, Wei, Bailey-Elkin, Ben A, Knaap, Robert C M, Khare, Baldeep, Dalebout, Tim J, Johnson, Garrett G, van Kasteren, Puck B, McLeish, Nigel J, Gu, Jun, He, Wenguang, Kikkert, Marjolein, Mark, Brian L, Sidhu, Sachdev S

“…The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to…”
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Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium by Zaloba, Patryk, Bailey-Elkin, Ben A, Derksen, Miriam, Mark, Brian L

“…FlgJ is a glycoside hydrolase (GH) enzyme belonging to the Carbohydrate Active enZyme (CAZy) family GH73. It facilitates passage of the bacterial flagellum…”
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Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease by Karumuthil-Melethil, Subha, Nagabhushan Kalburgi, Sahana, Thompson, Patrick, Tropak, Michael, Kaytor, Michael D, Keimel, John G, Mark, Brian L, Mahuran, Don, Walia, Jagdeep S, Gray, Steven J

“…GM2 gangliosidosis is a family of three genetic neurodegenerative disorders caused by the accumulation of GM2 ganglioside (GM2) in neuronal tissue. Two of…”
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Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease by James, Terrence W, Frias-Staheli, Natalia, Bacik, John-Paul, Levingston Macleod, Jesica M, Khajehpour, Mazdak, García-Sastre, Adolfo, Mark, Brian L

“…The attachment of ubiquitin (Ub) and the Ub-like (Ubl) molecule interferon-stimulated gene 15 (ISG15) to cellular proteins mediates important innate antiviral…”
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Estimation of maximum interference-free power level for opportunistic spectrum access by Mark, Brian L., Nasif, Ahmed O.

“…We consider a scenario in which frequency agile radios opportunistically share a fixed spectrum resource with a set of primary nodes. We develop a…”
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Viral OTU deubiquitinases: a structural and functional comparison by Bailey-Elkin, Ben A, van Kasteren, Puck B, Snijder, Eric J, Kikkert, Marjolein, Mark, Brian L

“…Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU)…”
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Mutation of a Gene Essential for Ribosome Biogenesis, EMG1, Causes Bowen-Conradi Syndrome by Armistead, Joy, Khatkar, Sunita, Meyer, Britta, Mark, Brian L., Patel, Nehal, Coghlan, Gail, Lamont, Ryan E., Liu, Shuangbo, Wiechert, Jill, Cattini, Peter A., Koetter, Peter, Wrogemann, Klaus, Greenberg, Cheryl R., Entian, Karl-Dieter, Zelinski, Teresa, Triggs-Raine, Barbara

“…Bowen-Conradi syndrome (BCS) is an autosomal-recessive disorder characterized by severely impaired prenatal and postnatal growth, profound psychomotor…”
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Inactivation of the Glycoside Hydrolase NagZ Attenuates Antipseudomonal β-Lactam Resistance in Pseudomonas aeruginosa by ASGARALI, Azizah, STUBBS, Keith A, OLIVER, Antonio, VOCADLO, David J, MARK, Brian L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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AmpG Inactivation Restores Susceptibility of Pan-β-Lactam-Resistant Pseudomonas aeruginosa Clinical Strains by ZAMORANO, Laura, REEVE, Thomas M, JUAN, Carlos, MOYA, Bartolome, CABOT, Gabriel, VOCADLO, David J, MARK, Brian L, OLIVER, Antonio

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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E-Hermes: A robust cooperative trust establishment scheme for mobile ad hoc networks by Zouridaki, Charikleia, Mark, Brian L., Hejmo, Marek, Thomas, Roshan K.

“…In a mobile ad hoc network (MANET), a source node must rely on intermediate nodes to forward its packets along multi-hop routes to the destination node. Due to…”
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