Search Results - "MARGOLIS, Seth S"

Hats off to 20S proteasome substrate discovery by Church, Taylor R, Brennan, Anna, Margolis, Seth S

“…Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their…”
Get full text

Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor by Shin, Nah-Young, Yamazaki, Hajime, Beniash, Elia, Yang, Xu, Margolis, Seth S., Pugach, Megan K., Simmer, James P., Margolis, Henry C.

“…Dental enamel comprises interwoven arrays of extremely long and narrow crystals of carbonated hydroxyapatite called enamel rods. Amelogenin (AMELX) is the…”
Get full text

EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation by Margolis, Seth S., Salogiannis, John, Lipton, David M., Mandel-Brehm, Caleigh, Wills, Zachary P., Mardinly, Alan R., Hu, Linda, Greer, Paul L., Bikoff, Jay B., Ho, Hsin-Yi Henry, Soskis, Michael J., Sahin, Mustafa, Greenberg, Michael E.

“…The mechanisms that promote excitatory synapse formation and maturation have been extensively studied. However, the molecular events that limit excitatory…”
Get full text

Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice by Sell, Gabrielle L., Xin, Wendy, Cook, Emily K., Zbinden, Mark A., Schaffer, Thomas B., O’Meally, Robert N., Cole, Robert N., Margolis, Seth S.

“…In humans, loss-of-function mutations in the UBE3A gene lead to the neurodevelopmental disorder Angelman syndrome (AS). AS patients have severe impairments in…”
Get full text

Metabolic Regulation of Oocyte Cell Death through the CaMKII-Mediated Phosphorylation of Caspase-2 by Nutt, Leta K., Margolis, Seth S., Jensen, Mette, Herman, Catherine E., Dunphy, William G., Rathmell, Jeffrey C., Kornbluth, Sally

“…Vertebrate female reproduction is limited by the oocyte stockpiles acquired during embryonic development. These are gradually depleted over the organism’s…”
Get full text

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function by Ramachandran, Kapil V, Margolis, Seth S

“…A 20S proteasome complex localizes to neuronal plasma membrane, where it produces and releases extracellular peptides that induce neuronal calcium signaling…”
Get full text

Proteasome cap particle regulates synapses by Türker, Fulya, Margolis, Seth S

“…Deubiquitylation by free 19S proteasome cap particle modulates synaptic transmission…”
Get full text

Application of Activity‐Based Probe, MV151, in the Mammalian Nervous System Reveals New Insights into Proteasome Changes in Human Alzheimer's Disease Brain by Turker, Fulya, Margolis, Seth S.

“…Proteasome complexes play a critical role in human brain health and disease. Despite enormous effort, proteasome composition, activity, and abundance in the…”
Get full text

Neuronal membrane proteasome-derived peptides modulate NMDAR-dependent neuronal signaling to promote changes in gene expression by Türker, Fulya, Brennan, Anna, Margolis, Seth S

“…The neuronal membrane proteasome (NMP) degrades intracellular proteins into peptides that are released directly into the extracellular space, whereby they…”
Get full text

Q&A with Seth S. Margolis and Eric Villalón Landeros by Margolis, Seth S., Landeros, Eric Villalón

“…Cell Reports speaks with Seth S. Margolis and Eric Villalón Landeros about their scientific journeys, experiences, and interests that have led to their recent…”
Get full text

Angelman Syndrome by Margolis, Seth S., Sell, Gabrielle L., Zbinden, Mark A., Bird, Lynne M.

“…In this review we summarize the clinical and genetic aspects of Angelman syndrome (AS), its molecular and cellular underpinnings, and current treatment…”
Get full text

Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome by Ramachandran, Kapil V., Fu, Jack M., Schaffer, Thomas B., Na, Chan Hyun, Delannoy, Michael, Margolis, Seth S.

“…Activity-dependent changes in neuronal function require coordinated regulation of the protein synthesis and protein degradation machinery to maintain protein…”
Get full text

Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity by He, Hai-Yan, Ahsan, Arifa, Bera, Reshmi, McLain, Natalie, Faulkner, Regina, Ramachandran, Kapil V, Margolis, Seth S, Cline, Hollis T

“…Protein degradation is critical for brain function through processes that remain incompletely understood. Here, we investigated the in vivo function of the 20S…”
Get full text

A Role for Cdc2- and PP2A-Mediated Regulation of Emi2 in the Maintenance of CSF Arrest by Wu, Qiju, Guo, Yanxiang, Yamada, Ayumi, Perry, Jennifer A., Wang, Michael Z., Araki, Marito, Freel, Christopher D., Tung, Jeffrey J., Tang, Wanli, Margolis, Seth S., Jackson, Peter K., Yamano, Hiroyuki, Asano, Maki, Kornbluth, Sally

“…Vertebrate oocytes are arrested in metaphase II of meiosis prior to fertilization by cytostatic factor (CSF). CSF enforces a cell-cycle arrest by inhibiting…”
Get full text

Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice by Sell, Gabrielle L, Schaffer, Thomas B, Margolis, Seth S

“…Accumulation of amyloid-β (Aβ) protein may cause synapse degeneration and cognitive impairment in Alzheimer's disease (AD) by reactivating expression of the…”
Get full text

Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue by Türker, Fulya, Bharadwaj, Rahul A., Kleinman, Joel E., Weinberger, Daniel R., Hyde, Thomas M., White, Cory J., Williams, Dionna W., Margolis, Seth S.

“…Proteasomes are large macromolecular complexes with multiple distinct catalytic activities that are each vital to human brain health and disease. Despite their…”
Get full text

C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity by Banik, Soma S. R., Guo, Chuanhai, Smith, Allyson C., Margolis, Seth S., Richardson, D. Ashley, Tirado, Carlos A., Counter, Christopher M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome by Villalón Landeros, Eric, Kho, Samuel C., Church, Taylor R., Brennan, Anna, Türker, Fulya, Delannoy, Michael, Caterina, Michael J., Margolis, Seth S.

“…Proteasomes are critical for peripheral nervous system (PNS) function. Here, we investigate mammalian PNS proteasomes and reveal the presence of the neuronal…”
Get full text

From UBE3A to Angelman syndrome: a substrate perspective by Sell, Gabrielle L, Margolis, Seth S

“…Angelman syndrome (AS) is a debilitating neurodevelopmental disorder that is characterized by motor dysfunction, intellectual disability, speech impairment,…”
Get full text

PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5 by Schaffer, Thomas B., Smith, Jaclyn E., Cook, Emily K., Phan, Thao, Margolis, Seth S.

“…Protein kinase C (PKC)-dependent mechanisms promote synaptic function in the mature brain. However, the roles of PKC signaling during synapse development…”
Get full text