Search Results - "MARDIS, Elaine"

DNA sequencing technologies: 2006–2016 by Mardis, Elaine R

“…In this Perspective, Elaine Mardis reviews a decade of DNA sequencing technology, from the introduction of Next-Generation Sequencing to single-molecule…”
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A decade’s perspective on DNA sequencing technology by Mardis, Elaine R.

“…Human genomics comes of age To mark the tenth anniversary of the publication reporting a draft sequence of the human genome by the Human Genome Project, this…”
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Next-Generation Sequencing Platforms by Mardis, Elaine R

“…Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's…”
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The emerging clinical relevance of genomics in cancer medicine by Berger, Michael F., Mardis, Elaine R.

“…The combination of next-generation sequencing and advanced computational data analysis approaches has revolutionized our understanding of the genomic…”
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Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response by Mardis, Elaine R

“…The resurgence of immune therapies in cancer medicine has elicited a corresponding interest in understanding the basis of patient response or resistance to…”
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Next-generation DNA sequencing methods by Mardis, Elaine R

“…Recent scientific discoveries that resulted from the application of next-generation DNA sequencing technologies highlight the striking impact of these…”
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The Impact of Next-Generation Sequencing on Cancer Genomics: From Discovery to Clinic by Mardis, Elaine R

“…The application of next-generation sequencing (NGS) technology to the study of cancer genomes has been transformational. Not only has this technology revealed…”
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Ten-Patient Trial: Remarkable Responses in Pediatric Cancers by Mardis, Elaine R

“…A clinical trial of nivolumab in 10 patients with pediatric cancer with high tumor mutational burden demonstrated complete responses in 50% of patients. This…”
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The impact of next-generation sequencing technology on genetics by Mardis, Elaine R

“…If one accepts that the fundamental pursuit of genetics is to determine the genotypes that explain phenotypes, the meteoric increase of DNA sequence…”
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Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers by Govindan, Ramaswamy, Ding, Li, Griffith, Malachi, Subramanian, Janakiraman, Dees, Nathan D., Kanchi, Krishna L., Maher, Christopher A., Fulton, Robert, Fulton, Lucinda, Wallis, John, Chen, Ken, Walker, Jason, McDonald, Sandra, Bose, Ron, Ornitz, David, Xiong, Donghai, You, Ming, Dooling, David J., Watson, Mark, Mardis, Elaine R., Wilson, Richard K.

“…We report the results of whole-genome and transcriptome sequencing of tumor and adjacent normal tissue samples from 17 patients with non-small cell lung…”
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Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis by Snyder, Alexandra, Nathanson, Tavi, Funt, Samuel A, Ahuja, Arun, Buros Novik, Jacqueline, Hellmann, Matthew D, Chang, Eliza, Aksoy, Bulent Arman, Al-Ahmadie, Hikmat, Yusko, Erik, Vignali, Marissa, Benzeno, Sharon, Boyd, Mariel, Moran, Meredith, Iyer, Gopa, Robins, Harlan S, Mardis, Elaine R, Merghoub, Taha, Hammerbacher, Jeff, Rosenberg, Jonathan E, Bajorin, Dean F

“…Inhibition of programmed death-ligand 1 (PD-L1) with atezolizumab can induce durable clinical benefit (DCB) in patients with metastatic urothelial cancers,…”
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Applications of Immunogenomics to Cancer by Liu, X. Shirley, Mardis, Elaine R.

“…Cancer immunogenomics originally was framed by research supporting the hypothesis that cancer mutations generated novel peptides seen as “non-self” by the…”
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Genomic prediction of neoantigens: immunogenomics before NGS by Mardis, Elaine R.

“…Elaine Mardis highlights a publication that served as a fundamental source of inspiration for the field of immunogenomics, setting the stage for neoantigen…”
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Tumor neoantigens: building a framework for personalized cancer immunotherapy by Gubin, Matthew M, Artyomov, Maxim N, Mardis, Elaine R, Schreiber, Robert D

“…It is now well established that the immune system can recognize developing cancers and that therapeutic manipulation of immunity can induce tumor regression…”
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Overview of modern genomic tools for diagnosis and precision therapy of childhood solid cancers by Mardis, Elaine R

“…The application of technology and computational analyses to generate new data types from pediatric solid cancers is transforming diagnostic accuracy. This…”
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Many mutations in one clinical-trial basket by Mardis, Elaine

“…When abnormality in a gene is linked to cancer and a drug targets the encoded protein, how can the patients who will respond to the drug be identified if the…”
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De Novo Gene Disruptions in Children on the Autistic Spectrum by Iossifov, Ivan, Ronemus, Michael, Levy, Dan, Wang, Zihua, Hakker, Inessa, Rosenbaum, Julie, Yamrom, Boris, Lee, Yoon-ha, Narzisi, Giuseppe, Leotta, Anthony, Kendall, Jude, Grabowska, Ewa, Ma, Beicong, Marks, Steven, Rodgers, Linda, Stepansky, Asya, Troge, Jennifer, Andrews, Peter, Bekritsky, Mitchell, Pradhan, Kith, Ghiban, Elena, Kramer, Melissa, Parla, Jennifer, Demeter, Ryan, Fulton, Lucinda L., Fulton, Robert S., Magrini, Vincent J., Ye, Kenny, Darnell, Jennifer C., Darnell, Robert B., Mardis, Elaine R., Wilson, Richard K., Schatz, Michael C., McCombie, W. Richard, Wigler, Michael

“…Exome sequencing of 343 families, each with a single child on the autism spectrum and at least one unaffected sibling, reveal de novo small indels and point…”
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The $1,000 genome, the $100,000 analysis? by Mardis, Elaine R

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The Next-Generation Sequencing Revolution and Its Impact on Genomics by Koboldt, Daniel C., Steinberg, Karyn Meltz, Larson, David E., Wilson, Richard K., Mardis, Elaine R.

“…Genomics is a relatively new scientific discipline, having DNA sequencing as its core technology. As technology has improved the cost and scale of genome…”
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SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution by Miller, Christopher A, White, Brian S, Dees, Nathan D, Griffith, Malachi, Welch, John S, Griffith, Obi L, Vij, Ravi, Tomasson, Michael H, Graubert, Timothy A, Walter, Matthew J, Ellis, Matthew J, Schierding, William, DiPersio, John F, Ley, Timothy J, Mardis, Elaine R, Wilson, Richard K, Ding, Li

“…The sensitivity of massively-parallel sequencing has confirmed that most cancers are oligoclonal, with subpopulations of neoplastic cells harboring distinct…”
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