Search Results - "MARCZYLO, Tim"
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Pulmonary effects of e-liquid flavors: a systematic review
Published in Journal of toxicology and environmental health. Part B, Critical reviews (03-10-2022)“…Electronic cigarettes (ECs) are purported to be tobacco harm-reduction products whose degree of harm has been highly debated. EC use is considered less…”
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Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-02-2020)“…Fatty acid amide hydrolase inhibition may be used to control bladder function and pain by modulating endocannabinoid levels in cystitis. We studied the effect…”
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Evaluating the impact of decontamination interventions performed in sequence for mass casualty chemical incidents
Published in Scientific reports (22-07-2021)“…The Initial Operational Response (IOR) to chemical incidents is a suite of rapid strategies including evacuation, disrobe and improvised and interim…”
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Author Correction: Human volunteer study of the decontamination of chemically contaminated hair and the consequences for systemic exposure
Published in Scientific reports (21-04-2021)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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A controlled cross-over study to evaluate the efficacy of improvised dry and wet emergency decontamination protocols for chemical incidents
Published in PloS one (04-11-2020)“…The UK Initial Operational Response (IOR) to chemical incidents includes improvised decontamination procedures, which use readily available materials to…”
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Human volunteer study of the decontamination of chemically contaminated hair and the consequences for systemic exposure
Published in Scientific reports (30-11-2020)“…The decontamination of exposed persons is a priority following the release of toxic chemicals. Efficacious decontamination reduces the risk of harm to those…”
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Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine
Published in Antioxidants & redox signaling (20-06-2013)“…Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is a widely used biomarker of oxidative stress. However, variability between chromatographic and ELISA…”
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Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation
Published in Particle and fibre toxicology (23-05-2018)“…Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO NPs) have the ability to…”
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Pilot study of oral anthocyanins for colorectal cancer chemoprevention
Published in Cancer prevention research (Philadelphia, Pa.) (01-07-2009)“…Naturally occurring anthocyanins possess colorectal cancer chemopreventive properties in rodent models. We investigated whether mirtocyan, an anthocyanin-rich…”
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Structure confirmation, reactivity, bacterial mutagenicity and quantification of 2,2,4-tribromo-5-hydroxycyclopent-4-ene-1,3-dione in drinking water
Published in Communications chemistry (14-11-2024)“…The presence of two new disinfectant by-product (DBP) groups in the UK was recently shown using non-target analysis, halogenated-hydroxycyclopentenediones and…”
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How bad are e‐cigarettes? What can we learn from animal exposure models?
Published in The Journal of physiology (01-11-2020)“…Electronic cigarettes divide opinions. Some consider them key to reducing smoking incidence while others are concerned over potential for detrimental health…”
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Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences
Published in Clinical cancer research (01-05-2006)“…Silibinin, a flavonolignan from milk thistle, has intestinal cancer chemopreventive efficacy in rodents. It is a strong antioxidant and modulates the…”
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Diagnostic Accuracy of Maternal Serum Macrophage Inhibitory Cytokine-1 and Pregnancy-Associated Plasma Protein-A at 6–10 Weeks of Gestation to Predict Miscarriage
Published in Obstetrics and gynecology (New York. 1953) (01-05-2012)“…OBJECTIVE:To determine whether serum macrophage inhibitory cytokine-1, pregnancy-associated plasma protein-A (PAPP-A), anandamide, or β-human chorionic…”
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Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells
Published in Molecular nutrition & food research (01-05-2011)“…Scope: The effect of two anthocyanin‐rich berry extracts (A, bilberry; B, red grape) on topoisomerases was investigated in a cell‐free system and in human HT29…”
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Chemicals in European residences – Part I: A review of emissions, concentrations and health effects of volatile organic compounds (VOCs)
Published in The Science of the total environment (15-09-2022)“…One of the more important classes of potentially toxic indoor air chemicals are the Volatile Organic Compounds (VOCs). However, due to a limited understanding…”
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Making sense of the latest evidence on electronic cigarettes
Published in The Lancet (British edition) (17-02-2018)“…The international tobacco control community was initially sceptical of ECs, but many experts and professional bodies now accept ECs are likely to be far less…”
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Identification of Novel Simulants for Toxic Industrial Chemicals and Chemical Warfare Agents for Human Decontamination Studies: A Systematic Review and Categorisation of Physicochemical Characteristics
Published in International journal of environmental research and public health (17-08-2021)“…Chemical simulants have long been used in human trials of mass decontamination to determine the efficacy of decontamination interventions against more toxic…”
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Toxicological assessment of E-cigarette flavored E-liquids aerosols using Calu-3 cells: A 3D lung model approach
Published in Toxicology (Amsterdam) (01-12-2023)“…Scientific progress and ethical considerations are increasingly shifting the toxicological focus from in vivo animal models to in vitro studies utilizing…”
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GC–MS/MS quantification of benzyl salicylate on skin and hair: A novel chemical simulant for human decontamination studies
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15-10-2019)“…•A previous GC-MS/MS method was modified for the analysis of benzyl salicylate in hair and skin.•Higher recovery and better measure of decontamination efficacy…”
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In Vitro high-throughput toxicological assessment of E-cigarette flavors on human bronchial epithelial cells and the potential involvement of TRPA1 in cinnamon flavor-induced toxicity
Published in Toxicology (Amsterdam) (01-09-2023)“…Electronic cigarettes (ECs) are considered a less hazardous alternative to tobacco smoking but are not harmless. Growing concerns about the safety profiles of…”
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