Search Results - "MARCOPULOS, N"

Enantioselective synthesis of 4-substituted phenylalanines by cross-coupling reactions by Firooznia, Fariborz, Gude, Candido, Chan, Kenneth, Marcopulos, Nicholas, Satoh, Yoshitaka

“…The enantiomerically enriched BOC-protected (4-pinacolylborono)phenylalanine methyl ester ( 8) is produced via enzymatic resolution of the racemic material, or…”
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Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 by Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E

“…High-throughput screening identified 5 as a weak inhibitor of 11β-HSD1. Optimization of the structure led to a series of perhydroquinolylbenzamides, some with…”
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Application of 5-lithiotetrazoles in organic synthesis by Satoh, Yoshitaka, Marcopulos, Nicholas

“…Lithiation of 1-benzyl and 1- p-methoxybenzyltetrazole at the 5-position with n-butyllithium followed by treatment with electrophiles gave functionalized…”
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Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme by Wallace, Eli M, Moliterni, John A, Moskal, Michael A, Neubert, Alan D, Marcopulos, Nicholas, Stamford, Lisa B, Trapani, Angelo J, Savage, Paula, Chou, Mary, Jeng, Arco Y

“…Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date. The final step of posttranslational processing of this peptide is the conversion…”
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Synthesis of tetrazole analogs of α-amino acids by alkylation of a Schiff base of α-aminomethyltetrazole by Satoh, Yoshitaka, De Lombaert, Stéphane, Marcopulos, Nicholas, Moliterni, John, Moskal, Michael, Tan, Jenny, Wallace, Eli

“…A benzophenone imine of N-1 protected α-aminomethyltetrazoles was found to undergo alkylation with organic halides in good yields. Deprotection afforded…”
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Diels-Alder reactions of dieno-pyranosides. Anomeric vs allylic stereoselection by GIULIANO, R. M, BUZBY, J. H, MARCOPULOS, N, SPRINGER, J. P

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Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives by Butera, John A, Spinelli, Walter, Anantharaman, Viji, Marcopulos, Nicholas, Parsons, Roderick W, Moubarak, Issam F, Cullinan, Catherine, Bagli, Jehan F

“…The synthesis and biological evaluation of a series of novel 1-(aryloxy)-2-propanolamines and several related deshydroxy analogues are described. Compounds…”
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Synthesis and selective class III antiarrythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives by BUTERA, J. A, SPINELLI, W, ANANTHARAMAN, V, MARCOPULOS, N, PARSONS, R. W, MOUBARAK, CULLINAN, C, BAGLI, J. F

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