Search Results - "MARCHAN, Rosemarie"

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses by Guth, Sabine, Hüser, Stephanie, Roth, Angelika, Degen, Gisela, Diel, Patrick, Edlund, Karolina, Eisenbrand, Gerhard, Engel, Karl-Heinz, Epe, Bernd, Grune, Tilman, Heinz, Volker, Henle, Thomas, Humpf, Hans-Ulrich, Jäger, Henry, Joost, Hans-Georg, Kulling, Sabine E., Lampen, Alfonso, Mally, Angela, Marchan, Rosemarie, Marko, Doris, Mühle, Eva, Nitsche, Michael A., Röhrdanz, Elke, Stadler, Richard, van Thriel, Christoph, Vieths, Stefan, Vogel, Rudi F., Wascher, Edmund, Watzl, Carsten, Nöthlings, Ute, Hengstler, Jan G.

“…Recently, epidemiological studies have suggested that fluoride is a human developmental neurotoxicant that reduces measures of intelligence in children,…”
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Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma by Marchan, Rosemarie, Büttner, Bettina, Lambert, Jörg, Edlund, Karolina, Glaeser, Iris, Blaszkewicz, Meinolf, Leonhardt, Gregor, Marienhoff, Lisa, Kaszta, Darius, Anft, Moritz, Watzl, Carsten, Madjar, Katrin, Grinberg, Marianna, Rempel, Eugen, Hergenröder, Roland, Selinski, Silvia, Rahnenführer, Jörg, Lesjak, Michaela S, Stewart, Joanna D, Cadenas, Cristina, Hengstler, Jan G

“…Glycerophosphodiesterase EDI3 (GPCPD1; GDE5; GDPD6) has been suggested to promote cell migration, adhesion, and spreading, but its mechanisms of action remain…”
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3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis by Kim, Jin-Young, Fluri, David A., Marchan, Rosemarie, Boonen, Kurt, Mohanty, Soumyaranjan, Singh, Prateek, Hammad, Seddik, Landuyt, Bart, Hengstler, Jan G., Kelm, Jens M., Hierlemann, Andreas, Frey, Olivier

“…•One-tissue format enables multiple tissue combinations on chip without design changes.•Tilting-based perfusion eliminates any tubing and ensures device…”
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Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations by Albrecht, Wiebke, Kappenberg, Franziska, Brecklinghaus, Tim, Stoeber, Regina, Marchan, Rosemarie, Zhang, Mian, Ebbert, Kristina, Kirschner, Hendrik, Grinberg, Marianna, Leist, Marcel, Moritz, Wolfgang, Cadenas, Cristina, Ghallab, Ahmed, Reinders, Jörg, Vartak, Nachiket, van Thriel, Christoph, Golka, Klaus, Tolosa, Laia, Castell, José V., Damm, Georg, Seehofer, Daniel, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Behr, Anne-Cathrin, Oberemm, Axel, Gu, Xiaolong, Kittana, Naim, van de Water, Bob, Kreiling, Reinhard, Fayyaz, Susann, van Aerts, Leon, Smedsrød, Bård, Ellinger-Ziegelbauer, Heidrun, Steger-Hartmann, Thomas, Gundert-Remy, Ursula, Zeigerer, Anja, Ullrich, Anett, Runge, Dieter, Lee, Serene M. L., Schiergens, Tobias S., Kuepfer, Lars, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Edlund, Karolina, Gardner, Iain, Rahnenführer, Jörg, Hengstler, Jan G.

“…Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the…”
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EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis by Glotzbach, Annika, Rohlf, Katharina, Gonscharow, Anastasia, Lüke, Simon, Demirci, Özlem, Begher-Tibbe, Brigitte, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G, Edlund, Karolina, Marchan, Rosemarie

“…Despite progress understanding the mechanisms underlying tumor spread, metastasis remains a clinical challenge. We identified the choline-producing…”
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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue by Godoy, Patricio, Widera, Agata, Schmidt-Heck, Wolfgang, Campos, Gisela, Meyer, Christoph, Cadenas, Cristina, Reif, Raymond, Stöber, Regina, Hammad, Seddik, Pütter, Larissa, Gianmoena, Kathrin, Marchan, Rosemarie, Ghallab, Ahmed, Edlund, Karolina, Nüssler, Andreas, Thasler, Wolfgang E., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Dirsch, Olaf, Dahmen, Uta, Gebhardt, Rolf, Chaudhari, Umesh, Meganathan, Kesavan, Sachinidis, Agapios, Kelm, Jens, Hofmann, Ute, Zahedi, René P., Guthke, Reinhard, Blüthgen, Nils, Dooley, Steven, Hengstler, Jan G.

“…It is well known that isolation and cultivation of primary hepatocytes cause major gene expression alterations. In the present genome-wide, time-resolved study…”
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Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease by Campos, Gisela, Schmidt-Heck, Wolfgang, De Smedt, Jonathan, Widera, Agata, Ghallab, Ahmed, Pütter, Larissa, González, Daniela, Edlund, Karolina, Cadenas, Cristina, Marchan, Rosemarie, Guthke, Reinhard, Verfaillie, Catherine, Hetz, Claudio, Sachinidis, Agapios, Braeuning, Albert, Schwarz, Michael, Weiß, Thomas S., Banhart, Benjamin K., Hoek, Jan, Vadigepalli, Rajanikanth, Willy, Jeffrey, Stevens, James L., Hay, David C., Hengstler, Jan G., Godoy, Patricio

“…Inflammation has been recognized as essential for restorative regeneration. Here, we analyzed the sequential processes during onset of liver injury and…”
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Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria by Gianmoena, Kathrin, Gasparoni, Nina, Jashari, Adelina, Gabrys, Philipp, Grgas, Katharina, Ghallab, Ahmed, Nordström, Karl, Gasparoni, Gilles, Reinders, Jörg, Edlund, Karolina, Godoy, Patricio, Schriewer, Alexander, Hayen, Heiko, Hudert, Christian A., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Boor, Peter, Anders, Hans-Joachim, Motrapu, Manga, Jansen, Peter, Schiergens, Tobias S., Falk-Paulsen, Maren, Rosenstiel, Philip, Lisowski, Clivia, Salido, Eduardo, Marchan, Rosemarie, Walter, Jörn, Hengstler, Jan G., Cadenas, Cristina

“…Epigenetic modifications (e.g. DNA methylation) in NAFLD and their contribution to disease progression and extrahepatic complications are poorly explored…”
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Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis by Hammad, Seddik, Hoehme, Stefan, Friebel, Adrian, von Recklinghausen, Iris, Othman, Amnah, Begher-Tibbe, Brigitte, Reif, Raymond, Godoy, Patricio, Johann, Tim, Vartak, Amruta, Golka, Klaus, Bucur, Petru O., Vibert, Eric, Marchan, Rosemarie, Christ, Bruno, Dooley, Steven, Meyer, Christoph, Ilkavets, Iryna, Dahmen, Uta, Dirsch, Olaf, Böttger, Jan, Gebhardt, Rolf, Drasdo, Dirk, Hengstler, Jan G.

“…Histological alterations often constitute a fingerprint of toxicity and diseases. The extent to which these alterations are cause or consequence of compromised…”
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Toxicogenomics directory of chemically exposed human hepatocytes by Grinberg, Marianna, Stöber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Jürgen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nüssler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, Marcel, Rahnenführer, Jörg, Hengstler, Jan G.

“…A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. Often, transcriptomics data are used…”
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Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis by Stewart, Joanna D, Marchan, Rosemarie, Lesjak, Michaela S, Lambert, Joerg, Hergenroeder, Roland, Ellis, James K, Lau, Chung-Ho, Keun, Hector C, Schmitz, Gerd, Schiller, Juergen, Eibisch, Mandy, Hedberg, Christian, Waldmann, Herbert, Lausch, Ekkehart, Tanner, Berno, Sehouli, Jalid, Sagemueller, Jens, Staude, Hagen, Steiner, Eric, Hengstler, Jan G

“…Metastasis from primary tumors remains a major problem for tumor therapy. In the search for markers of metastasis and more effective therapies, the tumor…”
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Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy by Hellwig, Birte, Madjar, Katrin, Edlund, Karolina, Marchan, Rosemarie, Cadenas, Cristina, Heimes, Anne-Sophie, Almstedt, Katrin, Lebrecht, Antje, Sicking, Isabel, Battista, Marco J, Micke, Patrick, Schmidt, Marcus, Hengstler, Jan G, Rahnenführer, Jörg

“…In breast cancer, gene signatures that predict the risk of metastasis after surgical tumor resection are mainly indicative of early events. The purpose of this…”
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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors by Rempel, Eugen, Hoelting, Lisa, Waldmann, Tanja, Balmer, Nina V., Schildknecht, Stefan, Grinberg, Marianna, Das Gaspar, John Antony, Shinde, Vaibhav, Stöber, Regina, Marchan, Rosemarie, van Thriel, Christoph, Liebing, Julia, Meisig, Johannes, Blüthgen, Nils, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., Leist, Marcel

“…Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a…”
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Contribution to the ongoing discussion on fluoride toxicity by Guth, Sabine, Hüser, Stephanie, Roth, Angelika, Degen, Gisela, Diel, Patrick, Edlund, Karolina, Eisenbrand, Gerhard, Engel, Karl-Heinz, Epe, Bernd, Grune, Tilman, Heinz, Volker, Henle, Thomas, Humpf, Hans-Ulrich, Jäger, Henry, Joost, Hans-Georg, Kulling, Sabine E., Lampen, Alfonso, Mally, Angela, Marchan, Rosemarie, Marko, Doris, Mühle, Eva, Nitsche, Michael A., Röhrdanz, Elke, Stadler, Richard, van Thriel, Christoph, Vieths, Stefan, Vogel, Rudi F., Wascher, Edmund, Watzl, Carsten, Nöthlings, Ute, Hengstler, Jan G.

“…Since the addition of fluoride to drinking water in the 1940s, there have been frequent and sometimes heated discussions regarding its benefits and risks. In a…”
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Glutathione Export during Apoptosis Requires Functional Multidrug Resistance-associated Proteins by Hammond, Christine L., Marchan, Rosemarie, Krance, Suzanne M., Ballatori, Nazzareno

“…GSH is released in cells undergoing apoptosis, and the present study indicates that the multidrug resistance-associated proteins (MRPs/ABCC) are responsible…”
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Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice by Fendt, Rebekka, Ghallab, Ahmed, Myllys, Maiju, Hofmann, Ute, Hassan, Reham, Hobloss, Zaynab, González, Daniela, Brackhagen, Lisa, Marchan, Rosemarie, Edlund, Karolina, Seddek, Abdel-Latif, Abdelmageed, Noha, Blank, Lars M., Schlender, Jan-Frederik, Holland, Christian H., Hengstler, Jan G., Kuepfer, Lars

“…Rationale: Liver cirrhosis is known to affect drug pharmacokinetics, but the functional assessment of the underlying pathophysiological alterations in drug…”
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Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers by Schwender, Holger, Selinski, Silvia, Blaszkewicz, Meinolf, Marchan, Rosemarie, Ickstadt, Katja, Golka, Klaus, Hengstler, Jan G

“…Recently, genome-wide association studies have identified and validated genetic variations associated with urinary bladder cancer (UBC). However, it is still…”
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Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth by Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G, Edlund, Karolina, Marchan, Rosemarie

“…Intrinsic or acquired resistance to HER2-targeted therapy is often a problem when small molecule tyrosine kinase inhibitors or antibodies are used to treat…”
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Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice by Holland, Christian H., Ramirez Flores, Ricardo O., Myllys, Maiju, Hassan, Reham, Edlund, Karolina, Hofmann, Ute, Marchan, Rosemarie, Cadenas, Cristina, Reinders, Jörg, Hoehme, Stefan, Seddek, Abdel‐latif, Dooley, Steven, Keitel, Verena, Godoy, Patricio, Begher‐Tibbe, Brigitte, Trautwein, Christian, Rupp, Christian, Mueller, Sebastian, Longerich, Thomas, Hengstler, Jan G., Saez‐Rodriguez, Julio, Ghallab, Ahmed

“…Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used…”
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Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study by Gajewski, Patrick D, Getzmann, Stephan, Bröde, Peter, Burke, Michael, Cadenas, Cristina, Capellino, Silvia, Claus, Maren, Genç, Erhan, Golka, Klaus, Hengstler, Jan G, Kleinsorge, Thomas, Marchan, Rosemarie, Nitsche, Michael A, Reinders, Jörg, van Thriel, Christoph, Watzl, Carsten, Wascher, Edmund

“…Previous research revealed several biological and environmental factors modulating cognitive functioning over a human's lifespan. However, the relationships…”
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