Search Results - "MARC, S"

PCSK9 inhibitors: clinical evidence and implementation by Sabatine, Marc S.

“…The gene encoding PCSK9 was first identified and linked to the phenotype of familial hypercholesterolaemia approximately 15 years ago. Soon after, studies…”
Get full text

Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review by Esplen, Nolan, Mendonca, Marc S, Bazalova-Carter, Magdalena

“…Ultrahigh dose-rate radiotherapy (RT), or 'FLASH' therapy, has gained significant momentum following various in vivo studies published since 2014 which have…”
Get more information

Studying Transcriptional Enhancers: The Founder Fallacy, Validation Creep, and Other Biases by Halfon, Marc S.

“…Transcriptional enhancers play a major role in regulating metazoan gene expression. Recent developments in genomics and next-generation sequencing have…”
Get full text

Silencers, Enhancers, and the Multifunctional Regulatory Genome by Halfon, Marc S.

“…Negative regulation of gene expression by transcriptional silencers has been difficult to study due to limited defined examples. A new study by Gisselbrecht et…”
Get full text

Venetoclax in myeloma: to B, or not to B by Raab, Marc S

Get full text

Replication protein A: Single‐stranded DNA's first responder: Dynamic DNA‐interactions allow replication protein A to direct single‐strand DNA intermediates into different pathways for synthesis or repair by Chen, Ran, Wold, Marc S

“…Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic cells, is required for processing of single‐stranded DNA (ssDNA)…”
Get full text

Routine consolidation of early stage primary bone lymphoma with radiation therapy does not improve outcomes by Hoffmann, Marc S

Get full text

Perspectives on Gene Regulatory Network Evolution by Halfon, Marc S

“…Animal development proceeds through the activity of genes and their cis -regulatory modules (CRMs) working together in sets of gene regulatory networks (GRNs)…”
Get full text

Population Screening in Health Systems by Williams, Marc S

“…Applications of genomics to population screening are expanding in the United States and internationally. Many of these programs are being implemented in the…”
Get full text

Bioaccumulation and risk assessment of organochlorine pesticides in fish from a global biodiversity hotspot: iSimangaliso Wetland Park, South Africa by Buah-Kwofie, Archibold, Humphries, Marc S., Pillay, Letitia

“…Organochlorine pesticides (OCPs) have been used extensively in the eastern regions of South Africa for agricultural and malaria control purposes, yet few data…”
Get full text

Early Lessons from the Implementation of Genomic Medicine Programs by Williams, Marc S

“…Massively parallel sequencing is emerging from research settings into clinical practice, helping the vision of precision medicine to become a reality. The most…”
Get full text

Minireview: Organizational Hypothesis: Instances of the Fingerpost by Breedlove, S. Marc

“…There is now compelling evidence that the ratio of the length of the second digit divided by the length of the fourth digit (2D:4D) is affected by prenatal…”
Get full text

Prenatal Influences on Human Sexual Orientation: Expectations versus Data by Breedlove, S. Marc

“…In non-human vertebrate species, sexual differentiation of the brain is primarily driven by androgens such as testosterone organizing the brains of males in a…”
Get full text

PCSK9 inhibitors: what we know, what we should have understood, and what is to come by Sabatine, Marc S

Get full text

Are PCSK9 Inhibitors the Next Breakthrough in the Cardiovascular Field? by Giugliano, Robert P., MD, SM, Sabatine, Marc S., MD, MPH

“…Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein receptor, escorting it to its destruction in the lysosome…”
Get full text

A dual‐process motivational model of attitudes towards vegetarians and vegans by Judge, Madeline, Wilson, Marc S.

“…Vegetarians and vegans comprise a minority of most western populations. However, relatively little research has investigated the psychological foundations of…”
Get full text

Age-associated B cells in autoimmune diseases by Mouat, Isobel C., Goldberg, Erin, Horwitz, Marc S.

“…Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell population. In addition to arising with age and following infection, ABCs…”
Get full text

The distribution of organochlorine pesticides in sediments from iSimangaliso Wetland Park: Ecological risks and implications for conservation in a biodiversity hotspot by Buah-Kwofie, Archibold, Humphries, Marc S.

“…The iSimangaliso Wetland Park World Heritage site, located on the east coast of South Africa, spans ∼3300 km2 and constitutes the largest protected estuarine…”
Get full text

COVID-19 and Cancer: a Comprehensive Review by Gosain, Rohit, Abdou, Yara, Singh, Abhay, Rana, Navpreet, Puzanov, Igor, Ernstoff, Marc S.

“…Purpose of Review The outbreak of the novel coronavirus disease 2019 (COVID-19) has emerged to be the biggest global health threat worldwide, which has now…”
Get full text

Minimum required number of specimen records to develop accurate species distribution models by van Proosdij, André S. J., Sosef, Marc S. M., Wieringa, Jan J., Raes, Niels

“…Species distribution models (SDMs) are widely used to predict the occurrence of species. Because SDMs generally use presence-only data, validation of the…”
Get full text