Search Results - "MARAZZI, Ivan"

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis by Shah, Priya S., Link, Nichole, Jang, Gwendolyn M., Sharp, Phillip P., Zhu, Tongtong, Swaney, Danielle L., Johnson, Jeffrey R., Von Dollen, John, Ramage, Holly R., Satkamp, Laura, Newton, Billy, Hüttenhain, Ruth, Petit, Marine J., Baum, Tierney, Everitt, Amanda, Laufman, Orly, Tassetto, Michel, Shales, Michael, Stevenson, Erica, Iglesias, Gabriel N., Shokat, Leila, Tripathi, Shashank, Balasubramaniam, Vinod, Webb, Laurence G., Aguirre, Sebastian, Willsey, A. Jeremy, Garcia-Sastre, Adolfo, Pollard, Katherine S., Cherry, Sara, Gamarnik, Andrea V., Marazzi, Ivan, Taunton, Jack, Fernandez-Sesma, Ana, Bellen, Hugo J., Andino, Raul, Krogan, Nevan J.

“…Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how…”
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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation by Rialdi, Alex, Campisi, Laura, Zhao, Nan, Lagda, Arvin Cesar, Pietzsch, Colette, Ho, Jessica Sook Yuin, Martinez-Gil, Luis, Fenouil, Romain, Chen, Xiaoting, Edwards, Megan, Metreveli, Giorgi, Jordan, Stefan, Peralta, Zuleyma, Munoz-Fontela, Cesar, Bouvier, Nicole, Merad, Miriam, Jin, Jian, Weirauch, Matthew, Heinz, Sven, Benner, Chris, van Bakel, Harm, Basler, Christopher, García-Sastre, Adolfo, Bukreyev, Alexander, Marazzi, Ivan

“…The host innate immune response is the first line of defense against pathogens and is orchestrated by the concerted expression of genes induced by microbial…”
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Suppression of the antiviral response by an influenza histone mimic by Marazzi, Ivan, Ho, Jessica S. Y., Kim, Jaehoon, Manicassamy, Balaji, Dewell, Scott, Albrecht, Randy A., Seibert, Chris W., Schaefer, Uwe, Jeffrey, Kate L., Prinjha, Rab K., Lee, Kevin, García-Sastre, Adolfo, Roeder, Robert G., Tarakhovsky, Alexander

“…Viral infection is commonly associated with virus-driven hijacking of host proteins. Here we describe a novel mechanism by which influenza virus affects host…”
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DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells by Lim, Jung-Yeon, Duttke, Sascha H, Baker, Turner S, Lee, Jihye, Gambino, Kristyne J, Venturini, Nicholas J, Ho, Jessica Sook Yuin, Zheng, Simin, Fstkchyan, Yesai S, Pillai, Vinodh, Fajgenbaum, David C, Marazzi, Ivan, Benner, Christopher, Byun, Minji

“…DNMT3A encodes an enzyme that carries out de novo DNA methylation, which is essential for the acquisition of cellular identity and specialized functions during…”
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Isoform-resolved transcriptome of the human preimplantation embryo by Torre, Denis, Francoeur, Nancy J., Kalma, Yael, Gross Carmel, Ilana, Melo, Betsaida S., Deikus, Gintaras, Allette, Kimaada, Flohr, Ron, Fridrikh, Maya, Vlachos, Konstantinos, Madrid, Kent, Shah, Hardik, Wang, Ying-Chih, Sridhar, Shwetha H., Smith, Melissa L., Eliyahu, Efrat, Azem, Foad, Amir, Hadar, Mayshar, Yoav, Marazzi, Ivan, Guccione, Ernesto, Schadt, Eric, Ben-Yosef, Dalit, Sebra, Robert

“…Human preimplantation development involves extensive remodeling of RNA expression and splicing. However, its transcriptome has been compiled using short-read…”
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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity by Rialdi, Alexander, Hultquist, Judd, Jimenez-Morales, David, Peralta, Zuleyma, Campisi, Laura, Fenouil, Romain, Moshkina, Natasha, Wang, Zhen Zhen, Laffleur, Brice, Kaake, Robyn M., McGregor, Michael J., Haas, Kelsey, Pefanis, Evangelos, Albrecht, Randy A., Pache, Lars, Chanda, Sumit, Jen, Joanna, Ochando, Jordi, Byun, Minji, Basu, Uttiya, García-Sastre, Adolfo, Krogan, Nevan, van Bakel, Harm, Marazzi, Ivan

“…The nuclear RNA exosome is an essential multi-subunit complex that controls RNA homeostasis. Congenital mutations in RNA exosome genes are associated with…”
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HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness by Ho, Jessica Sy, Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, JingXian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hall Hickman, Alexander, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Housheng Hansen, Greenbaum, Benjamin D, Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M, Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto

“…High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To…”
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Methylation of a Histone Mimic within the Histone Methyltransferase G9a Regulates Protein Complex Assembly by Sampath, Srihari C., Marazzi, Ivan, Yap, Kyoko L., Sampath, Srinath C., Krutchinsky, Andrew N., Mecklenbräuker, Ingrid, Viale, Agnes, Rudensky, Eugene, Zhou, Ming-Ming, Chait, Brian T., Tarakhovsky, Alexander

“…Epigenetic gene silencing in eukaryotes is regulated in part by lysine methylation of the core histone proteins. While histone lysine methylation is known to…”
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Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues by Zhou, Mingqi, Tamburini, Ian, Van, Cassandra, Molendijk, Jeffrey, Nguyen, Christy M, Chang, Ivan Yao-Yi, Johnson, Casey, Velez, Leandro M, Cheon, Youngseo, Yeo, Reichelle, Bae, Hosung, Le, Johnny, Larson, Natalie, Pulido, Ron, Nascimento-Filho, Carlos H V, Jang, Cholsoon, Marazzi, Ivan, Justice, Jamie, Pannunzio, Nicholas, Hevener, Andrea L, Sparks, Lauren, Kershaw, Erin, Nicholas, Dequina, Parker, Benjamin L, Masri, Selma, Seldin, Marcus M

“…Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes to many human diseases. Given that…”
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Suppression of inflammation by a synthetic histone mimic by NICODEME, Edwige, JEFFREY, Kate L, WHITE, Julia, KIRILOVSKY, Jorge, RICE, Charles M, LORA, Jose M, PRINJHA, Rab K, LEE, Kevin, TARAKHOVSKY, Alexander, SCHAEFER, Uwe, BEINKE, Soren, DEWELL, Scott, CHUNG, Chun-Wa, CHANDWANI, Rohit, MARAZZI, Ivan, WILSON, Paul, COSTE, Hervé

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A small nucleosome from a weird virus with a fat genome by Vannini, Alessandro, Marazzi, Ivan

“…Valencia-Sánchez et al. (2021) and Liu et al. (2021) provide structural and biological insights about the existence and importance of a nucleosome-like…”
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Unconventional viral gene expression mechanisms as therapeutic targets by Ho, Jessica Sook Yuin, Zhu, Zeyu, Marazzi, Ivan

“…Unlike the human genome that comprises mostly noncoding and regulatory sequences, viruses have evolved under the constraints of maintaining a small genome size…”
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Interference of viral effector proteins with chromatin, transcription, and the epigenome by Marazzi, Ivan, Garcia-Sastre, Adolfo

“…Highlights • Pathogens exploit cellular functions to their own advantage to create an environment conducive to their persistence and propagation. • Viruses and…”
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Transcription Elongation Can Affect Genome 3D Structure by Heinz, Sven, Texari, Lorane, Hayes, Michael G.B., Urbanowski, Matthew, Chang, Max W., Givarkes, Ninvita, Rialdi, Alexander, White, Kris M., Albrecht, Randy A., Pache, Lars, Marazzi, Ivan, García-Sastre, Adolfo, Shaw, Megan L., Benner, Christopher

“…How transcription affects genome 3D organization is not well understood. We found that during influenza A (IAV) infection, rampant transcription rapidly…”
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Human Virus Transcriptional Regulators by Liu, Xing, Hong, Ted, Parameswaran, Sreeja, Ernst, Kevin, Marazzi, Ivan, Weirauch, Matthew T., Fuxman Bass, Juan I.

“…Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough…”
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Chromatin dependencies in cancer and inflammation by Marazzi, Ivan, Greenbaum, Benjamin D., Low, Diana H. P., Guccione, Ernesto

“…Key Points Cell signalling pathways converge on chromatin, where they induce transcriptional programmes. The inducible programmes are regulated by shared…”
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Suppression of inflammation by a synthetic histone mimic by Schaefer, Uwe, Coste, Hervé, Marazzi, Ivan, Dewell, Scott, Kirilovsky, Jorge, Beinke, Soren, Rice, Charles M, Lee, Kevin, Lora, Jose M, Chandwani, Rohit, Chung, Chun-wa, Tarakhovsky, Alexander, Jeffrey, Kate L, Prinjha, Rab K, Nicodeme, Edwige, White, Julia, Wilson, Paul

“…Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune…”
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3052 – CLONAL HEMATOPOIESIS-ASSOCIATED DNMT3A HAPLOINSUFFICIENCY CAUSES DICHOTOMOUS DNA METHYLATION DEFECTS AT ENHANCERS IN MATURE HUMAN IMMUNE CELLS by Byun, Minji, Lim, Jung-Yeon, Duttke, Sascha, Baker, Turner, lee, Jihye, Marazzi, Ivan, Benner, Christopher

“…DNMT3A encodes an enzyme that carries out de novo DNA methylation, which is essential for the acquisition of cellular identity and specialized functions during…”
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Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance by Braza, Mounia S., van Leent, Mandy M.T., Lameijer, Marnix, Sanchez-Gaytan, Brenda L., Arts, Rob J.W., Pérez-Medina, Carlos, Conde, Patricia, Garcia, Mercedes R., Gonzalez-Perez, Maria, Brahmachary, Manisha, Fay, Francois, Kluza, Ewelina, Kossatz, Susanne, Dress, Regine J., Salem, Fadi, Rialdi, Alexander, Reiner, Thomas, Boros, Peter, Strijkers, Gustav J., Calcagno, Claudia C., Ginhoux, Florent, Marazzi, Ivan, Lutgens, Esther, Nicolaes, Gerry A.F., Weber, Christian, Swirski, Filip K., Nahrendorf, Matthias, Fisher, Edward A., Duivenvoorden, Raphaël, Fayad, Zahi A., Netea, Mihai G., Mulder, Willem J.M., Ochando, Jordi

“…Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transplantation. Using an experimental transplantation mouse…”
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TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation by Ho, Jessica Sook Yuin, Mok, Bobo Wing-Yee, Campisi, Laura, Jordan, Tristan, Yildiz, Soner, Parameswaran, Sreeja, Wayman, Joseph A., Gaudreault, Natasha N., Meekins, David A., Indran, Sabarish V., Morozov, Igor, Trujillo, Jessie D., Fstkchyan, Yesai S., Rathnasinghe, Raveen, Zhu, Zeyu, Zheng, Simin, Zhao, Nan, White, Kris, Ray-Jones, Helen, Malysheva, Valeriya, Thiecke, Michiel J., Lau, Siu-Ying, Liu, Honglian, Zhang, Anna Junxia, Lee, Andrew Chak-Yiu, Liu, Wen-Chun, Jangra, Sonia, Escalera, Alba, Aydillo, Teresa, Melo, Betsaida Salom, Guccione, Ernesto, Sebra, Robert, Shum, Elaine, Bakker, Jan, Kaufman, David A., Moreira, Andre L., Carossino, Mariano, Balasuriya, Udeni B.R., Byun, Minji, Albrecht, Randy A., Schotsaert, Michael, Garcia-Sastre, Adolfo, Chanda, Sumit K., Miraldi, Emily R., Jeyasekharan, Anand D., TenOever, Benjamin R., Spivakov, Mikhail, Weirauch, Matthew T., Heinz, Sven, Chen, Honglin, Benner, Christopher, Richt, Juergen A., Marazzi, Ivan

“…The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large…”
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