Search Results - "MARATHE, Himangi"

Functional screen identifies regulators of murine hematopoietic stem cell repopulation by Holmfeldt, Per, Ganuza, Miguel, Marathe, Himangi, He, Bing, Hall, Trent, Kang, Guolian, Moen, Joseph, Pardieck, Jennifer, Saulsberry, Angelica C, Cico, Alba, Gaut, Ludovic, McGoldrick, Daniel, Finkelstein, David, Tan, Kai, McKinney-Freeman, Shannon

“…Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. To discover…”
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Understanding Drug Sensitivity and Tackling Resistance in Cancer by Tyner, Jeffrey W, Haderk, Franziska, Kumaraswamy, Anbarasu, Baughn, Linda B, Van Ness, Brian, Liu, Song, Marathe, Himangi, Alumkal, Joshi J, Bivona, Trever G, Chan, Keith Syson, Druker, Brian J, Hutson, Alan D, Nelson, Peter S, Sawyers, Charles L, Willey, Christopher D

“…Decades of research into the molecular mechanisms of cancer and the development of novel therapeutics have yielded a number of remarkable successes. However,…”
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Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer by GANG REN, BARITAKI, Stavroula, DAIGNAULT, Stephanie, AL-MULLA, Fahd, KELLER, Evan, BONAVIDA, Ben, DE LA SERNA, Ivana, YEUNG, Kam C, MARATHE, Himangi, JINGWEI FENG, PARK, Sungdae, BEACH, Sandy, BAZELEY, Peter S, BESHIR, Anwar B, FENTEANY, Gabriel, MEHRA, Rohit

“…Epigenetic modifications such as histone methylation play an important role in human cancer metastasis. Enhancer of zeste homolog 2 (EZH2), which encodes the…”
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BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation by Marathe, Himangi G, Watkins-Chow, Dawn E, Weider, Matthias, Hoffmann, Alana, Mehta, Gaurav, Trivedi, Archit, Aras, Shweta, Basuroy, Tupa, Mehrotra, Aanchal, Bennett, Dorothy C, Wegner, Michael, Pavan, William J, de la Serna, Ivana L

“…Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as…”
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SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression by Marathe, Himangi G, Mehta, Gaurav, Zhang, Xiaolu, Datar, Ila, Mehrotra, Aanchal, Yeung, Kam C, de la Serna, Ivana L

“…SOX10 is a Sry-related high mobility (HMG)-box transcriptional regulator that promotes differentiation of neural crest precursors into Schwann cells,…”
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Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness by Saladi, Srinivas Vinod, Keenen, Bridget, Marathe, Himangi G, Qi, Huiling, Chin, Khew-Voon, de la Serna, Ivana L

“…Metastatic melanoma is an aggressive malignancy that is resistant to therapy and has a poor prognosis. The progression of primary melanoma to metastatic…”
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BAF60A mediates interactions between the microphthalmia‐associated transcription factor and the BRG1‐containing SWI/SNF complex during melanocyte differentiation by Aras, Shweta, Saladi, Srinivas Vinod, Basuroy, Tupa, Marathe, Himangi G., Lorès, Patrick, Serna, Ivana L.

“…SWI/SNF chromatin remodeling enzymes are multisubunit complexes that contain one of two catalytic subunits, BRG1 or BRM and 9–11 additional subunits called…”
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Eutherian-Specific Functions of BetaM Acquired through Atp1b4 Gene Co-Option in the Regulation of MyoD Expression by Ahmad, Nisar, de la Serna, Ivana L, Marathe, Himangi G, Fan, Xiaoming, Dube, Prabhatchandra, Zhang, Shungang, Haller, Steven T, Kennedy, David J, Pestov, Nikolay B, Modyanov, Nikolai N

“…Vertebrate genes represent a rare instance of orthologous gene co-option, resulting in radically different functions of the encoded BetaM proteins. In lower…”
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Ten challenges and opportunities in computational immuno-oncology by Bao, Riyue, Hutson, Alan, Madabhushi, Anant, Jonsson, Vanessa D, Rosario, Spencer R, Barnholtz-Sloan, Jill S, Fertig, Elana J, Marathe, Himangi, Harris, Lyndsay, Altreuter, Jennifer, Chen, Qingrong, Dignam, James, Gentles, Andrew J, Gonzalez-Kozlova, Edgar, Gnjatic, Sacha, Kim, Erika, Long, Mark, Morgan, Martin, Ruppin, Eytan, Valen, David Van, Zhang, Hong, Vokes, Natalie, Meerzaman, Daoud, Liu, Song, Van Allen, Eliezer M, Xing, Yi

“…Immuno-oncology has transformed the treatment of cancer, with several immunotherapies becoming the standard treatment across histologies. Despite these…”
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BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene by Saladi, Srinivas V., Wong, Philip G., Trivedi, Archit R., Marathe, Himangi G., Keenen, Bridget, Aras, Shweta, Liew, Zi-Qi, Setaluri, Vijayasaradhi, de la Serna, Ivana L.

“…Summary Microphthalmia‐associated transcription factor (MITF) is a survival factor in melanocytes and melanoma cells. MITF regulates expression of…”
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SWItching on the transcriptional circuitry in melanoma by Vinod Saladi, Srinivas, Marathe, Himangi, de la Serna, Ivana L.

“…Melanoma is an aggressive malignancy that is resistant to current therapy, and the most lethal of all human skin cancers. It is characterized by several…”
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The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage by Punch, Patrick R, Irons, Eric E, Manhardt, Charles T, Marathe, Himangi, Lau, Joseph T Y

“…Abstract High-dose irradiation poses extreme risk of mortality from acute damage to the hematopoietic compartment and gastrointestinal tract. While bone marrow…”
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The Cancer Moonshot Immuno-Oncology Translational Network at 5: accelerating cancer immunotherapies by Annapragada, Ananth, Sikora, Andrew G, Marathe, Himangi, Liu, Song, Demetriou, Michael, Fong, Lawrence, Gao, Jinming, Kufe, Donald, Morris, Zachary S, Vilar, Eduardo, Sharon, Elad, Hutson, Alan, Odunsi, Kunle

“…Abstract The Immuno-Oncology Translational Network (IOTN) was established in 2018 as part of the Cancer Moonshot. In 2022, President Joe Biden set new goals to…”
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929 The data management and resource sharing center for the cancer moonshot immuno-oncology translational network by Hutson, Alan, Marathe, Himangi, Morgan, Martin, Odunsi, Kunle, Liu, Song

“…BackgroundBackground: Despite regulatory approval and advancements of immune-based interventions over the last decade, significant obstacles remain to be…”
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BAF60A mediates interactions between MITF and the BRG1-containing SWI/SNF complex during melanocyte differentiation by Aras, Shweta, Saladi, Srinivas Vinod, Basuroy, Tupa, Marathe, Himangi, G., Lorès, Patrick, de la Serna, Ivana L.

“…SWI/SNF chromatin remodeling enzymes are multi-subunit complexes that contain one of two catalytic subunits, BRG1 or BRM, and 9–11 additional subunits called…”
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Eutherian-Specific Functions of BetaM Acquired through IAtp1b4/I Gene Co-Option in the Regulation of MyoD Expression by Ahmad, Nisar, de la Serna, Ivana L, Marathe, Himangi G, Fan, Xiaoming, Dube, Prabhatchandra, Zhang, Shungang, Haller, Steven T, Kennedy, David J, Pestov, Nikolay B, Modyanov, Nikolai N

“…Vertebrate ATP1B4 genes represent a rare instance of orthologous gene co-option, resulting in radically different functions of the encoded BetaM proteins. In…”
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Functional Screen Identifies Novel Regulators of Murine Hematopoietic Stem Cell Engraftment by Ganuza Fernandez, Miguel, Holmfeldt, Per, Marathe, Himangi, Hall, Trent, Pardieck, Jennifer, McKinney-Freeman, Shannon

“…Introduction: Hematopoiesis involves the hierarchical generation of the major blood lineages from a common ancestor, the Hematopoietic Stem Cell (HSC). HSC…”
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Correction: Functional screen identifies regulators of murine hematopoietic stem cell repopulation by Holmfeldt, Per, Ganuza, Miguel, Marathe, Himangi, He, Bing, Hall, Trent, Kang, Guolian, Moen, Joseph, Pardieck, Jennifer, Saulsberry, Angelica C, Cico, Alba, Gaut, Ludovic, McGoldrick, Daniel, Finkelstein, David, Tan, Kai, McKinney-Freeman, Shannon

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SWI/SNF Chromatin Remodeling Enzymes as Regulators of Neural-crest Derived Cell Differentiation by Marathe, Himangi

“…Neural crest cells are multi-potent cells that migrate along predefined paths as progenitor cells and differentiate into a plethora of cell types upon reaching…”
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BRG 1 promotes survival of UV ‐irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene by Saladi, Srinivas V., Wong, Philip G., Trivedi, Archit R., Marathe, Himangi G., Keenen, Bridget, Aras, Shweta, Liew, Zi‐Qi, Setaluri, Vijayasaradhi, de la Serna, Ivana L.

“…Microphthalmia‐associated transcription factor ( MITF ) is a survival factor in melanocytes and melanoma cells. MITF regulates expression of antiapoptotic…”
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