Search Results - "MARANIAN, Mel"

Posterior vitreous detachment in absentia by Maranian, Mel J., Snead, Martin P.

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A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity by Barnett, Gillian C, Thompson, Deborah, Fachal, Laura, Kerns, Sarah, Talbot, Chris, Elliott, Rebecca M, Dorling, Leila, Coles, Charlotte E, Dearnaley, David P, Rosenstein, Barry S, Vega, Ana, Symonds, Paul, Yarnold, John, Baynes, Caroline, Michailidou, Kyriaki, Dennis, Joe, Tyrer, Jonathan P, Wilkinson, Jennifer S, Gómez-Caamaño, Antonio, Tanteles, George A, Platte, Radka, Mayes, Rebecca, Conroy, Don, Maranian, Mel, Luccarini, Craig, Gulliford, Sarah L, Sydes, Matthew R, Hall, Emma, Haviland, Joanne, Misra, Vivek, Titley, Jennifer, Bentzen, Søren M, Pharoah, Paul D.P, Burnet, Neil G, Dunning, Alison M, West, Catharine M.L

“…Abstract Background and purpose This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity 2 years after…”
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CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen by Abraham, Jean E, Maranian, Mel J, Driver, Kristy E, Platte, Radka, Kalmyrzaev, Bolot, Baynes, Caroline, Luccarini, Craig, Shah, Mitul, Ingle, Susan, Greenberg, David, Earl, Helena M, Dunning, Alison M, Pharoah, Paul D P, Caldas, Carlos

“…Tamoxifen is one of the most effective adjuvant breast cancer therapies available. Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6),…”
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SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice by Casey, Ruth T., ten Hoopen, Rogier, Ochoa, Eguzkine, Challis, Benjamin G., Whitworth, James, Smith, Philip S., Martin, Jose Ezequiel, Clark, Graeme R., Rodger, Fay, Maranian, Mel, Allinson, Kieren, Madhu, Basetti, Roberts, Thomas, Campos, Luis, Anstee, Joanne, Park, Soo-Mi, Marker, Alison, Watts, Colin, Bulusu, Venkata R., Giger, Olivier T., Maher, Eamonn R.

“…The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of function predisposes to the development of…”
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Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping by Abraham, Jean E, Maranian, Mel J, Spiteri, Inmaculada, Russell, Roslin, Ingle, Susan, Luccarini, Craig, Earl, Helena M, Pharoah, Paul P D, Dunning, Alison M, Caldas, Carlos

“…The increasing trend for incorporation of biological sample collection within clinical trials requires sample collection procedures which are convenient and…”
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Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1 by Maranian, Mel J., Kar, Siddhartha, O’Reilly, Martin, Betts, Joshua A., Hillman, Kristine M., Kaufmann, Susanne, Canisius, Sander, Southey, Melissa C., Schmidt, Marjanka K., Hogervorst, Frans B., Muir, Kenneth, Ruebner, Matthias, Beckmann, Matthias W., Fletcher, Olivia, Bolla, Manjeet K., Wang, Qin, Sawyer, Elinor J., Tomlinson, Ian, Miller, Nicola, Burwinkel, Barbara, Yang, Rongxi, Surowy, Harald, Truong, Thérèse, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, González-Neira, Anna, Benitez, Javier, Brenner, Hermann, Dieffenbach, Aida Karina, Meindl, Alfons, Schmutzler, Rita K., Brauch, Hiltrud, Nevanlinna, Heli, Muranen, Taru A., Blomqvist, Carl, Bogdanova, Natalia V., Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Tseng, Chiu-chen, Van Den Berg, David, Lambrechts, Diether, Zhao, Hui, Weltens, Caroline, van Limbergen, Erik, Flesch-Janys, Dieter, Rudolph, Anja, Radice, Paolo, Capra, Fabio, Couch, Fergus J., Vachon, Celine, Haiman, Christopher A., Le Marchand, Loic, Simard, Jacques, Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Ikram, M. Kamran, Kristensen, Vessela, Shrubsole, Martha, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Tollenaar, Robert A.E.M., Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Darabi, Hatef, Eriksson, Mikael, Martens, John W.M., Collée, J. Margriet, Shu, Xiao-Ou, Noh, Dong-Young, Hartman, Mikael, Hamann, Ute, Jaworska, Katarzyna, Durda, Katarzyna, Brennan, Paul, Olswold, Curtis, Slager, Susan, Yannoukakos, Drakoulis, Shen, Chen-Yang, Yu, Jyh-Cherng, Swerdlow, Anthony, Orr, Nick, Jones, Michael, Pita, Guillermo, Herrero, Daniel, Vincent, Daniel, Bacot, Francois, Ahmed, Shahana, Ponder, Bruce A.J., Chenevix-Trench, Georgia, Easton, Douglas F., French, Juliet D.

“…Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an…”
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CYP2D6 Gene Variants and Their Association with Breast Cancer Susceptibility by ABRAHAM, Jean E, MARANIAN, Mel J, CALDAS, Carlos, DRIVER, Kristy E, PLATTE, Radka, KALMYRZAEV, Bolot, BAYNES, Caroline, LUCCARINI, Craig, EARL, Helena M, DUNNING, Alison M, PHAROAH, Paul D. P

“…The gene encoding the phase I enzyme cytochrome P4502D6 (CYP2D6) has been previously investigated for its potential predictive role in the efficacy of breast…”
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A Novel Transcriptome Approach to the Investigation of the Molecular Pathology of Vitreous and Retinal Detachment by Maranian, Mel, Snead, Martin

“…Retinal detachment (RD) is one of the most common, sight-threatening ocular conditions requiring emergency intervention. Posterior vitreous detachment (PVD)…”
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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer by Lindstrom, Sara, Dennis, Joe, Maranian, Mel J, Brand, Judith S, Nordestgaard, Børge G, Flyger, Henrik, Rahman, Nazneen, Fletcher, Olivia, Nevanlinna, Heli, Muranen, Taru A, Aaltonen, Kirsimari, Ahsan, Habibul, John, Esther M, Gammon, Marilie D, Ursin, Giske, Schmidt, Daniel F, Gapstur, Susan M, Gaudet, Mia M, Diver, W Ryan, Schumacher, Fredrick, Hoover, Robert N, Lambrechts, Diether, Wildiers, Hans, van Limbergen, Erik, Broeks, Annegien, Cornelissen, Sten, Couch, Fergus J, Olson, Janet E, Hallberg, Emily, Meijers-Heijboer, Hanne, Ito, Hidemi, Iwata, Hiroji, Guénel, Pascal, Sanchez, Marie, Marme, Frederik, Surowy, Harald, Sohn, Christof, Van Den Berg, David, Benitez, Javier, Lu, Wei, Gao, Yu-Tang, Andrulis, Irene L, Knight, Julia A, Mulligan, Anna Marie, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Lindblom, Annika, Hollestelle, Antoinette, Collée, J Margriet, Blot, William, Signorello, Lisa B, Cai, Qiuyin, Hou, Ming-Feng, Kristensen, Vessela N, Milne, Roger L, McLean, Catriona, Peeters, Petra, Khaw, Kay-Tee, Palli, Domenico, Mortensen, Lotte Maxild, Dossus, Laure, Meindl, Alfons, Sutter, Christian, Yang, Rongxi, Muir, Kenneth, Siriwanarangsan, Pornthep, Miao, Hui, Chia, Kee Seng, Chan, Ching Wan, Fasching, Peter A, Beckmann, Matthias W, Haeberle, Lothar, Brenner, Hermann, Stegmaier, Christa, Ashworth, Alan, Schoemaker, Minouk J, Brinton, Louise, Zheng, Wei, Grip, Mervi, Brauch, Hiltrud, Radice, Paolo, Manoukian, Siranoush, Bernard, Loris, Dörk, Thilo, Hartikainen, Jaana M, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J, Brennan, Paul, McKay, James, Neuhausen, Susan L, Baynes, Caroline, Ahmed, Shahana, Healey, Catherine S, Herrero, Daniel, Simard, Jacques, Chenevix-Trench, Georgia, Hall, Per, Easton, Douglas F

“…Doug Easton and colleagues report the results of a large-scale genome-wide association study of breast cancer. They discover 15 new susceptibility loci and…”
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Genome-wide association study identifies five new breast cancer susceptibility loci by Turnbull, Clare, Ahmed, Shahana, Morrison, Jonathan, Pernet, David, Renwick, Anthony, Maranian, Mel, Seal, Sheila, Ghoussaini, Maya, Hines, Sarah, Healey, Catherine S, Hughes, Deborah, Warren-Perry, Margaret, Tapper, William, Eccles, Diana, Evans, D Gareth, Hooning, Maartje, Schutte, Mieke, van den Ouweland, Ans, Houlston, Richard, Ross, Gillian, Langford, Cordelia, Pharoah, Paul D P, Stratton, Michael R, Dunning, Alison M, Rahman, Nazneen, Easton, Douglas F

“…Douglas Easton and colleagues report a genome-wide association study for breast cancer, identifying five new susceptibility loci. Breast cancer is the most…”
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Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers by Ghoussaini, Maya, Edwards, Stacey L., Meyer, Kerstin B., Ahmed, Shahana, Betts, Joshua A., Dicks, Ed, Beesley, Jonathan, Tyrer, Jonathan, Barnes, Daniel, Alonso, M. Rosario, Tessier, Daniel C., Luccarini, Craig, Baynes, Caroline, Bolla, Manjeet K., Wang, Qin, Southey, Melissa C., Schmidt, Marjanka K., Broeks, Annegien, Verhoef, Senno, Cornelissen, Sten, Muir, Kenneth, Lophatananon, Artitaya, Siriwanarangsan, Pornthep, Loehberg, Christian R., Ekici, Arif B., dos Santos Silva, Isabel, Johnson, Nichola, Tomlinson, Ian, Truong, Thérèse, Menegaux, Florence, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Milne, Roger L., Benitez, Javier, Anton-Culver, Hoda, Brenner, Hermann, Stegmaier, Christa, Meindl, Alfons, Aittomäki, Kristiina, Matsuo, Keitaro, Iwata, Hiroji, Antonenkova, Natalia N., Dörk, Thilo, Mannermaa, Arto, Stram, Daniel O., Floris, Giuseppe, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Bonanni, Bernardo, Couch, Fergus J., Pankratz, Vernon S., Giles, Graham G., Severi, Gianluca, Haiman, Christopher A., Schumacher, Fredrick, Simard, Jacques, Goldberg, Mark S., Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Pylkäs, Katri, Glendon, Gord, Seynaeve, Caroline, Figueroa, Jonine, Lissowska, Jolanta, Schoof, Nils, Martens, John W.M., Collée, J. Margriet, Tilanus-Linthorst, Madeleine, Hall, Per, Humphreys, Keith, Shu, Xiao-Ou, Gao, Yu-Tang, Cai, Hui, Cox, Angela, Balasubramanian, Sabapathy P., Blot, William, Pharoah, Paul D.P., Healey, Catherine S., Pooley, Karen A., Yoo, Keun-Young, Miao, Hui, Sim, Xueling, Jaworska-Bieniek, Katarzyna, Gaborieau, Valerie, Toland, Amanda E., Chen, Shou-Tung, Swerdlow, Anthony, Ashworth, Alan, Schoemaker, Minouk J., Nevanlinna, Heli, Chenevix-Trench, Georgia, Easton, Douglas F., Dunning, Alison M.

“…Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for…”
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CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer by Thompson, Deborah J, O'Mara, Tracy A, Glubb, Dylan M, Painter, Jodie N, Cheng, Timothy, Folkerd, Elizabeth, Doody, Deborah, Dennis, Joe, Webb, Penelope M, Gorman, Maggie, Martin, Lynn, Hodgson, Shirley, Michailidou, Kyriaki, Tyrer, Jonathan P, Maranian, Mel J, Hall, Per, Czene, Kamila, Darabi, Hatef, Li, Jingmei, Fasching, Peter A, Hein, Alexander, Beckmann, Matthias W, Ekici, Arif B, Dörk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo, Zhao, Hui, Depreeuw, Jeroen, Schrauwen, Stefanie, Amant, Frederic, Goode, Ellen L, Fridley, Brooke L, Dowdy, Sean C, Winham, Stacey J, Salvesen, Helga B, Trovik, Jone, Njolstad, Tormund S, Werner, Henrica M J, Ashton, Katie, Proietto, Tony, Otton, Geoffrey, Carvajal-Carmona, Luis, Tham, Emma, Liu, Tao, Mints, Miriam, Scott, Rodney J, McEvoy, Mark, Attia, John, Holliday, Elizabeth G, Montgomery, Grant W, Martin, Nicholas G, Nyholt, Dale R, Henders, Anjali K, Hopper, John L, Traficante, Nadia, Ruebner, Matthias, Swerdlow, Anthony J, Burwinkel, Barbara, Brenner, Hermann, Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Lambrechts, Diether, Chang-Claude, Jenny, Couch, Fergus J, Giles, Graham G, Kristensen, Vessela N, Cox, Angela, Bolla, Manjeet K, Wang, Qin, Bojesen, Stig E, Shah, Mitul, Luben, Robert, Khaw, Kay-Tee, Pharoah, Paul D P, Dunning, Alison M, Tomlinson, Ian, Dowsett, Mitch, Easton, Douglas F, Spurdle, Amanda B

“…Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol (E2) concentrations. We analyzed 2937 single…”
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Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene by Dicks, Ed, Song, Honglin, Ramus, Susan J, Oudenhove, Elke Van, Tyrer, Jonathan P, Intermaggio, Maria P, Kar, Siddhartha, Harrington, Patricia, Bowtell, David D, Group, Aocs Study, Cicek, Mine S, Cunningham, Julie M, Fridley, Brooke L, Alsop, Jennifer, Jimenez-Linan, Mercedes, Piskorz, Anna, Goranova, Teodora, Kent, Emma, Siddiqui, Nadeem, Paul, James, Crawford, Robin, Poblete, Samantha, Lele, Shashi, Sucheston-Campbell, Lara, Moysich, Kirsten B, Sieh, Weiva, McGuire, Valerie, Lester, Jenny, Odunsi, Kunle, Whittemore, Alice S, Bogdanova, Natalia, Dürst, Matthias, Hillemanns, Peter, Karlan, Beth Y, Gentry-Maharaj, Aleksandra, Menon, Usha, Tischkowitz, Marc, Levine, Douglas, Brenton, James D, Dörk, Thilo, Goode, Ellen L, Gayther, Simon A, Pharoah, D P Paul

“…We analyzed whole exome sequencing data in germline DNA from 412 high grade serous ovarian cancer (HGSOC) cases from The Cancer Genome Atlas Project and…”
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A High-Density Screen for Linkage in Multiple Sclerosis by Sawcer, Stephen, Ban, Maria, Maranian, Mel, Yeo, Tai Wai, Compston, Alastair, Kirby, Andrew, Daly, Mark J, De Jager, Philip L, Walsh, Emily, Lander, Eric S, Rioux, John D, Hafler, David A, Ivinson, Adrian, Rimmler, Jacqueline, Gregory, Simon G, Schmidt, Silke, Pericak-Vance, Margaret A, Akesson, Eva, Hillert, Jan, Datta, Pameli, Oturai, Annette, Ryder, Lars P, Harbo, Hanne F, Spurkland, Anne, Myhr, Kjell-Morten, Laaksonen, Mikko, Booth, David, Heard, Robert, Stewart, Graeme, Lincoln, Robin, Barcellos, Lisa F, Hauser, Stephen L, Oksenberg, Jorge R, Kenealy, Shannon J, Haines, Jonathan L

“…To provide a definitive linkage map for multiple sclerosis, we have genotyped the Illumina BeadArray linkage mapping panel (version 4) in a data set of 730…”
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A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility by SAWCER, Stephen, MARANIAN, Mel, DEANS, Jackie, GOODFELLOW, Peter N, WALKER, Neil, CLAYTON, David, COMPSTON, Alastair, SETAKIS, Efrosini, CURWEN, Val, AKESSON, Eva, HENSIEK, Anke, CORADDU, Francesca, ROXBURGH, Richard, SAWCER, David, GRAY, Julia

“…Linkage analysis in multiplex families has provisionally identified several genomic regions where genes influencing susceptibility to multiple sclerosis are…”
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Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping by Sawcer, Stephen J, Maranian, Mel, Singlehurst, Sara, Yeo, TaiWai, Compston, Alastair, Daly, Mark J, De Jager, Philip L, Gabriel, Stacey, Hafler, David A, Ivinson, Adrian J, Lander, Eric S, Rioux, John D, Walsh, Emily, Gregory, Simon G, Schmidt, Silke, Pericak-Vance, Margaret A, Barcellos, Lisa, Hauser, Stephen L, Oksenberg, Jorge R, Kenealy, Shannon J, Haines, Jonathan L

“…To explore the potential value of recently developed high-density linkage mapping methods in the analysis of complex disease we have regenotyped five nuclear…”
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No evidence of a significant role for CTLA-4 in multiple sclerosis by Roxburgh, Richard H., Sawcer, Stephen, Maranian, Mel, Seaman, Shaun, Hensiek, Anke, Yeo, Taiwai, Deans, Jackie, Compston, Alastair

“…Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease…”
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Four single nucleotide polymorphisms from the vitamin D receptor gene in UK multiple sclerosis by Yeo, Tai Wai, Maranian, Mel, Singlehurst, Sara, Gray, Julia, Compston, Alastair, Sawcer, Stephen

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SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis by Fenoglio, Chiara, Galimberti, Daniela, Ban, Maria, Maranian, Mel, Scalabrini, Diego, Venturelli, Eliana, Piccio, Laura, De Riz, Milena, Yeo, Tai Wai, Goris, An, Gray, Julia, Bresolin, Nereo, Scarpini, Elio, Compston, Alastair, Sawcer, Stephen

“…P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a…”
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Refining the analysis of a whole genome linkage disequilibrium association map: the United Kingdom results by Yeo, Tai Wai, Roxburgh, Richard, Maranian, Mel, Singlehurst, Sara, Gray, Julia, Hensiek, Anke, Setakis, Efrosini, Compston, Alastair, Sawcer, Stephen

“…Individual genotyping of the 10 most promising markers identified in our previously reported screen for linkage disequilibrium (LD) in multiple sclerosis…”
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