Search Results - "MARANGOS, N"

Identification of a diphtheria toxin‐like gene family beyond the Corynebacterium genus by Mansfield, Michael J., Sugiman‐Marangos, Seiji N., Melnyk, Roman A., Doxey, Andrew C.

“…Diphtheria toxin (DT), produced by Corynebacterium diphtheria, is the causative agent of diphtheria and one of the most potent protein toxins known; however,…”
Get full text

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies by Gill, Shivneet K, Sugiman-Marangos, Seiji N, Beilhartz, Greg L, Mei, Elizabeth, Taipale, Mikko, Melnyk, Roman A

“…Targeted intracellular delivery of therapeutic proteins remains a significant unmet challenge in biotechnology. A promising approach is to leverage the…”
Get full text

Mechanism for accurate, protein-assisted DNA annealing by Deinococcus radiodurans DdrB by Sugiman-Marangos, Seiji N., Weiss, Yoni M., Junop, Murray S.

“…Accurate pairing of DNA strands is essential for repair of DNA double-strand breaks (DSBs). How cells achieve accurate annealing when large regions of…”
Get full text

Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells by Park, Minyoung, Xu, Xiaobai, Min, Weixian, Sugiman-Marangos, Seiji N, Beilhartz, Greg L, Adams, Jarret J, Sidhu, Sachdev S, Grunebaum, Eyal, Melnyk, Roman A

“…Despite a wealth of potential applications inside target cells, protein-based therapeutics are largely limited to extracellular targets due to the inability of…”
Get full text

Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold by Sugiman-Marangos, Seiji N., Gill, Shivneet K., Mansfield, Michael J., Orrell, Kathleen E., Doxey, Andrew C., Melnyk, Roman A.

“…Diphtheria toxin (DT) is the archetype for bacterial exotoxins implicated in human diseases and has played a central role in defining the field of toxinology…”
Get full text

Red Blood Cell Distribution Width: Another Prognostic Factor for COVID-19? by Lagadinou, Maria, Gkentzi, Despoina, Marangos, Markos N., Paliogianni, Fotini, Solomou, Elena E.

“…The coronavirus disease 2019 (COVID-19) is a pandemic with a high rate of hospitalization, admission to intensive care units, and mortality. Identifying…”
Get full text

Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy by Sugiman-Marangos, Seiji N, Beilhartz, Greg L, Zhao, Xiaochu, Zhou, Dongxia, Hua, Rong, Kim, Peter K, Rini, James M, Minassian, Berge A, Melnyk, Roman A

“…Enzyme replacement therapy, in which a functional copy of an enzyme is injected either systemically or directly into the brain of affected individuals, has…”
Get full text

Repurposing bacterial toxins for intracellular delivery of therapeutic proteins by Beilhartz, Greg L., Sugiman-Marangos, Seiji N., Melnyk, Roman A.

“…[Display omitted] Despite enormous efforts, achieving efficacious levels of proteins inside mammalian cells remains one of the greatest challenges in…”
Get full text

Comparative Effects of Ciprofloxacin and Ceftazidime on Cytokine Production in Patients with Severe Sepsis Caused by Gram-Negative Bacteria by GOGOS, C. A, SKOUTELIS, A, LEKKOU, A, DROSOU, E, STARAKIS, I, MARANGOS, M. N, BASSARIS, H. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells by Orrell, Kathleen E, Zhang, Zhifen, Sugiman-Marangos, Seiji N, Melnyk, Roman A

“…The most potent toxins secreted by pathogenic bacteria contain enzymatic moieties that must reach the cytosol of target cells to exert their full toxicity…”
Get more information

Length of exposure to the hospital environment is more important than antibiotic exposure in healthcare associated infections by methicillin-resistant Staphylococcus aureus: a comparative study by Baraboutis, Ioannis G., Tsagalou, Eleftheria P., Papakonstantinou, Ilias, Marangos, Markos N., Gogos, Charalambos, Skoutelis, Athanasios T., Bassaris, Haralambos (Harry), Johnson, Stuart

“…Both total antimicrobial use and specific antimicrobials have been implicated as risk factors for healthcare-associated methicillin-resistant Staphylococcus…”
Get full text

Length of exposure to the hospital environment is more important than antibiotic exposure in healthcare associated infections by methicillin-resistant Staphylococcus aureus: a comparative study by Baraboutis, Ioannis G, Tsagalou, Eleftheria P, Papakonstantinou, Ilias, Marangos, Markos N, Gogos, Charalambos, Skoutelis, Athanasios T, Bassaris, Haralambos, Johnson, Stuart

“…OBJECTIVES: Both total antimicrobial use and specific antimicrobials have been implicated as risk factors for healthcare-associated methicillin-resistant…”
Get full text

Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants by Gupta, Pulkit, Zhang, Zhifen, Sugiman-Marangos, Seiji N., Tam, John, Raman, Swetha, Julien, Jean-Phillipe, Kroh, Heather K., Lacy, D. Borden, Murgolo, Nicholas, Bekkari, Kavitha, Therien, Alex G., Hernandez, Lorraine D., Melnyk, Roman A.

“…Clostridium difficile is a major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the primary determinant in human…”
Get full text

Listeriosis infection of an abdominal aortic aneurysm in a diabetic patient by Papadoulas, Spyros, Kakkos, Stavros, Kraniotis, Pantelis, Manousi, Maria, Marangos, Markos, Tsolakis, Ioannis

“…A rare case of an abdominal aortic aneurysm (AAA) infected by Listeria monocytogenes in a 72-year-old male diabetic farmer, is reported. Our patient had a…”
Get full text

The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions by Buensuceso, Ryan N C, Nguyen, Ylan, Zhang, Kun, Daniel-Ivad, Martin, Sugiman-Marangos, Seiji N, Fleetwood, Aaron D, Zhulin, Igor B, Junop, Murray S, Howell, P Lynne, Burrows, Lori L

“…FimV is a Pseudomonas aeruginosa inner membrane protein that regulates intracellular cyclic AMP (cAMP) levels-and thus type IV pilus (T4P)-mediated twitching…”
Get full text

Paraganglioma as a systemic syndrome: pitfalls and strategies by Maier, W, Marangos, N, Laszig, R

“…Tumours of the neuroendocrine system in the head and neck region are mostly paragangliomas of the glomus tympanicum or jugulare, or of the carotid body. The…”
Get more information

Antibiotic prophylaxis in primary hip and knee arthroplasty: comparison between cefuroxime and two specific antistaphylococcal agents by Tyllianakis, Minos E, Karageorgos, Athanasios Ch, Marangos, Markos N, Saridis, Alkis G, Lambiris, Elias E

“…This is a prospective randomized study comparing cefuroxime to 2 antistaphylococal agents (fusidic acid and vancomycin), for prophylaxis in total hip…”
Get full text

The first case of Staphylococcus aureus ST398 causing bacteremia in an immunocompromised patient in Greece by Drougka, E, Foka, A, Marangos, MN, Liakopoulos, A, Makatsoris, T, Anastassiou, ED, Petinaki, E, Spiliopoulou, I

“…We describe a case of catheter-related bloodstream infection, in a patient with colon cancer, caused by a methicillin-sensitive Staphylococcus aureus strain,…”
Get full text

Tetanus: pathophysiology and management by Ernst, M E, Klepser, M E, Fouts, M, Marangos, M N

“…To review the epidemiology, pathophysiology, clinical manifestations, diagnosis, and management of tetanus and its complications. MEDLINE and Iowa Drug…”
Get more information

Crystal structure of the DdrB/ssDNA complex from Deinococcus radiodurans reveals a DNA binding surface involving higher-order oligomeric states by Sugiman-Marangos, Seiji N, Peel, John K, Weiss, Yoni M, Ghirlando, Rodolfo, Junop, Murray S

“…The ability of Deinococcus radiodurans to recover from extensive DNA damage is due in part to its ability to efficiently repair its genome, even following…”
Get full text