Search Results - "MARAGAKIS, N. J"

Multipoint incremental motor unit number estimation as an outcome measure in ALS by SHEFNER, J. M, WATSON, M. L, SIMIONESCU, L, CARESS, J. B, BURNS, T. M, MARAGAKIS, N. J, BENATAR, M, DAVID, W. S, SHARMA, K. R, RUTKOVE, S. B

“…Improved outcome measures are necessary to reduce sample size and increase power in amyotrophic lateral sclerosis (ALS) clinical trials. Motor unit number…”
Get full text

Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis by Roth, N. M., Saidha, S., Zimmermann, H., Brandt, A. U., Oberwahrenbrock, T., Maragakis, N. J., Tumani, H., Ludolph, A. C., Meyer, T., Calabresi, P. A., Paul, F.

“…Background and purpose In recent years a possible non‐motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of…”
Get full text

Glutamate transporters in neurologic disease by Maragakis, N J, Rothstein, J D

Get more information

Targeted stem cell transplantation strategies in ALS by Lepore, A.C., Maragakis, N.J.

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that results in paralysis and ultimately death due to respiratory failure…”
Get full text

Focal Loss of the Glutamate Transporter EAAT2 in a Transgenic Rat Model of SOD1 Mutant-Mediated Amyotrophic Lateral Sclerosis (ALS) by Howland, David S., Liu, Jian, She, Yijin, Goad, Beth, Maragakis, Nicholas J., Kim, Benjamin, Erickson, Jamie, Kulik, John, DeVito, Lisa, Psaltis, George, DeGennaro, Louis J., Cleveland, Don W., Rothstein, Jeffrey D.

“…Transgenic overexpression of Cu+2/Zn+2superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation…”
Get full text

Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors by Lladó, Jerònia, Haenggeli, Christine, Maragakis, Nicholas J., Snyder, Evan Y., Rothstein, Jeffrey D.

“…Besides their capacity to give rise to neurons and/or glia, neural stem cells (NSCs) appear to inherently secrete neurotrophic factors beneficial to injured…”
Get full text

Human Embryonic Germ Cell Derivatives Facilitate Motor Recovery of Rats with Diffuse Motor Neuron Injury by Kerr, Douglas A, Llado, Jeronia, Shamblott, Michael J, Maragakis, Nicholas J, Irani, David N, Crawford, Thomas O, Krishnan, Chitra, Dike, Sonny, Gearhart, John D, Rothstein, Jeffrey D

“…We have investigated the potential of human pluripotent cells to restore function in rats paralyzed with a virus-induced motor neuronopathy. Cells derived from…”
Get full text

Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons by Irwin, R P, Maragakis, N J, Rogawski, M A, Purdy, R H, Farb, D H, Paul, S M

“…The ability of the neuroactive steroid pregnenolone sulfate to alter N-methyl-D-aspartate (NMDA) receptor-mediated elevations in intracellular Ca2+ ([Ca2+]i)…”
Get more information

A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus by Ueki, Takatoshi, Tanaka, Masamitsu, Yamashita, Kanna, Mikawa, Sumiko, Qiu, ZheFu, Maragakis, Nicholas J, Hevner, Robert F, Miura, Naoyuki, Sugimura, Haruhiko, Sato, Kohji

“…Neurogenesis occurs in restricted regions in the adult mammalian brain, among which the neurogenesis in the hippocampal dentate gyrus plays the crucial role in…”
Get full text

Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis by Teng, Yang D, Benn, Susanna C, Kalkanis, Steven N, Shefner, Jeremy M, Onario, Renna C, Cheng, Bin, Lachyankar, Mahesh B, Marconi, Michael, Li, Jianxue, Yu, Dou, Han, Inbo, Maragakis, Nicholas J, Lládo, Jeronia, Erkmen, Kadir, Redmond, Jr, D Eugene, Sidman, Richard L, Przedborski, Serge, Rothstein, Jeffrey D, Brown, Jr, Robert H, Snyder, Evan Y

“…Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting degeneration of motor neurons. Multiple processes involving motor…”
Get more information

Targeted stem cell transplantation strategies in ALS: Mechanisms of neurodegeneration by LEPORE, A. C, MARAGAKIS, N. J

Get full text

Glutamate transporters: animal models to neurologic disease by Maragakis, Nicholas J, Rothstein, Jeffrey D

“…Glutamate is the primary excitatory amino acid neurotransmitter in the central nervous system and its activity is carefully modulated in the synaptic cleft by…”
Get full text

COURAGE-ALS: a randomized, double-blind phase 3 study designed to improve participant experience and increase the probability of success by Shefner, Jeremy M., Al-Chalabi, Ammar, Andrews, Jinsy A., Chio, Adriano, De Carvalho, Mamede, Cockroft, Bettina M., Corcia, Philippe, Couratier, Philippe, Cudkowicz, Merit E., Genge, Angela, Hardiman, Orla, Heiman-Patterson, Terry, Henderson, Robert D., Ingre, Caroline, Jackson, Carlayne E., Johnston, Wendy, Lechtzin, Noah, Ludolph, Albert, Maragakis, Nicholas J., Miller, Timothy M., Mora Pardina, Jesus S., Petri, Susanne, Simmons, Zachary, Van Den Berg, Leonard H., Zinman, Lorne, Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Simkins, Tyrell J., Wei, Jenny, Wolff, Andrew A., Rudnicki, Stacy A.

“…Objective: To determine the target population and optimize the study design of the phase 3 clinical trial evaluating reldesemtiv in participants with…”
Get full text

Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1 super(G) super(9) super(3) super(A) model of ALS by Lepore, A C, Haenggeli, C, Gasmi, M, Bishop, K M, Bartus, R T, Maragakis, N J, Rothstein, J D

“…The potent neuroprotective activities of neurotrophic factors, including insulin-like growth factor 1 (IGF-1), make them promising candidates for treatment of…”
Get full text

Altered expression of the glutamate transporter EAAT2b in neurological disease by Maragakis, Nicholas J., Dykes-Hoberg, Margaret, Rothstein, Jeffrey D.

“…Functional studies suggest that up to 95% of all glutamate transport is handled by the glutamate transporter EAAT2. Amino and C‐terminal antibodies demonstrate…”
Get full text

Motoneuron Disease: Clinical by Ilieva, Hristelina, Maragakis, Nicholas J

“…ALS is a neurodegenerative disease in which the primary symptoms result in progressive neuromuscular weakness. Recent studies have highlighted that there is…”
Get more information

Selective up-regulation of the glial Na +-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection by Ganel, Raquelli, Ho, Tony, Maragakis, Nicholas J., Jackson, Mandy, Steiner, Joseph P., Rothstein, Jeffrey D.

“…Excessive accumulation of extracellular glutamate results in neuronal death. Termination of synaptic glutamate transmission and the prevention of…”
Get full text

Viral-Induced Spinal Motor Neuron Death Is Non-Cell-Autonomous and Involves Glutamate Excitotoxicity by Darman, Jessica, Backovic, Stephanie, Dike, Sonny, Maragakis, Nicholas J, Krishnan, Chitra, Rothstein, Jeffrey D, Irani, David N, Kerr, Douglas A

“…Neuroadapted Sindbis virus (NSV) is a neurotropic virus capable of inducing the death of spinal motor neurons in mice and rats. In this study we investigated…”
Get full text

Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS by Lladó, Jerònia, Haenggeli, Christine, Pardo, Andrea, Wong, Victor, Benson, Leah, Coccia, Carol, Rothstein, Jeffrey D., Shefner, Jeremy M., Maragakis, Nicholas J.

“…The transgenic mutant superoxide dismutase (SOD1) mice and rats have been important tools in attempting to understand motor neuron pathology and degeneration…”
Get full text

Glutamate transporter expression and function in human glial progenitors by Maragakis, Nicholas J., Dietrich, Joerg, Wong, Victor, Xue, Haipeng, Mayer-Proschel, Margot, Rao, Mahendra S., Rothstein, Jeffrey D.

“…Glutamate is the major neurotransmitter of the brain, whose extracellular levels are tightly controlled by glutamate transporters. Five glutamate transporters…”
Get full text