Search Results - "MAO, Hui Z"
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Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
Published in Nature genetics (01-12-2007)“…Hypertriglyceridemia is a hallmark of many disorders, including metabolic syndrome, diabetes, atherosclerosis and obesity. A well-known cause is the deficiency…”
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Identification of the βTP site in the x-ray structure of F₁-ATPase as the high-affinity catalytic site
Published in Proceedings of the National Academy of Sciences - PNAS (20-11-2007)“…ATP synthase uses a unique rotary mechanism to couple ATP synthesis and hydrolysis to transmembrane proton translocation. The F₁ subcomplex has three catalytic…”
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Journal Article -
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Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice
Published in Diabetes (New York, N.Y.) (01-07-2010)“…To identify metabolic derangements contributing to diabetes susceptibility in the leptin receptor-deficient obese C57BLKS/J-db/db (BKS-db) mouse strain. Young…”
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Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains
Published in Biochimica et biophysica acta (01-04-2006)“…The C57BLKS/J (BKS) inbred mouse strain is a widely used animal model of type 2 diabetes. In the presence of the diabetes ( db) mutation, obese BKS- db mice…”
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Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis
Published in Human molecular genetics (15-07-2017)“…The human transmembrane 6 superfamily member 2 (TM6SF2) gene has been implicated in plasma lipoprotein metabolism, alcoholic and non-alcoholic fatty liver…”
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Oxygen-Derived Free Radicals Contribute to Baroreceptor Dysfunction in Atherosclerotic Rabbits
Published in Circulation research (01-10-1996)“…The goal of the present study was to determine whether oxygen-derived free radicals contribute to baroreceptor dysfunction in atherosclerosis. Baroreceptor…”
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Lipase Maturation Factor 1 (Lmf1) Is Induced by Endoplasmic Reticulum Stress Through Activating Transcription Factor 6α (Atf6α) Signaling
Published in The Journal of biological chemistry (29-08-2014)“…Lipase maturation factor 1 (Lmf1) is a critical determinant of plasma lipid metabolism, as demonstrated by severe hypertriglyceridemia associated with its…”
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Transgenic Expression and Genetic Variation of Lmf1 Affect LPL Activity in Mice and Humans
Published in Arteriosclerosis, thrombosis, and vascular biology (01-05-2012)“…OBJECTIVE—Lipoprotein lipase (LPL) is a principal enzyme in lipoprotein metabolism, tissue lipid utilization, and energy metabolism. LPL is synthesized by…”
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A Functionally Important Hydrogen-bonding Network at the βDP/αDP Interface of ATP Synthase
Published in The Journal of biological chemistry (05-09-2008)“…ATP synthase uses a unique rotary mechanism to couple ATP synthesis and hydrolysis to transmembrane proton translocation. The F1 subcomplex has three catalytic…”
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Maturation of lipoprotein lipase in the endoplasmic reticulum. Concurrent formation of functional dimers and inactive aggregates
Published in The Journal of biological chemistry (22-03-2002)“…The maturation of lipoprotein lipase (LPL) into a catalytically active enzyme was believed to occur only after its transport from the endoplasmic reticulum…”
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Does F1‐ATPase have a catalytic site that preferentially binds MgADP?
Published in FEBS letters (24-07-2006)“…During ATP synthesis, ATP synthase has to bind MgADP in the presence of an excess of MgATP. Thus, for efficient ATP synthesis it would be desirable if incoming…”
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The cld mutation: narrowing the critical chromosomal region and selecting candidate genes
Published in Mammalian genome (01-10-2006)“…Combined lipase deficiency (cld) is a recessive, lethal mutation specific to the tw73 haplotype on mouse Chromosome 17. While the cld mutation results in…”
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Clonidine Prevents Insulin Resistance and Hypertension in Obese Dogs
Published in Hypertension (Dallas, Tex. 1979) (01-01-1999)“…The role that the central sympathetic nervous system plays in the development of obesity hypertension and insulin was evaluated by feeding dogs a high fat diet…”
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Journal Article Conference Proceeding -
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Modulation of baroreceptor activity by gene transfer of nitric oxide synthase to carotid sinus adventitia
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-05-2003)“…Administration of nitric oxide (NO) or NO donors to isolated carotid sinus and carotid bodies inhibits the activity of baroreceptor and chemoreceptor afferent…”
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Maturation of Lipoprotein Lipase in the Endoplasmic Reticulum
Published in The Journal of biological chemistry (22-03-2002)“…The maturation of lipoprotein lipase (LPL) into a catalytically active enzyme was believed to occur only after its transport from the endoplasmic reticulum…”
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Journal Article -
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Platelet Activation in Carotid Sinuses Triggers Reflex Sympathoinhibition and Hypotension
Published in Hypertension (Dallas, Tex. 1979) (01-03-1996)“…The carotid sinuses, one of the major sites of baroreceptor innervation, are also a common site of atherosclerotic lesions and platelet aggregation. The goal…”
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Journal Article Conference Proceeding -
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Gene Transfer to Carotid Sinus In Vivo: A Novel Approach to Investigation of Baroreceptors
Published in Hypertension (Dallas, Tex. 1979) (01-09-1997)“…Baroreceptor nerve endings are located in the adventitia of the carotid sinuses and aortic arch. The goal of the present study was to develop a method for gene…”
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Journal Article Conference Proceeding -
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Identification of the$\beta _{{\rm TP}}$Site in the X-Ray Structure of F₁-ATPase as the High-Affinity Catalytic Site
Published in Proceedings of the National Academy of Sciences - PNAS (20-11-2007)“…ATP synthase uses a unique rotary mechanism to couple ATP synthesis and hydrolysis to transmembrane proton translocation. The F₁ subcomplex has three catalytic…”
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Journal Article -
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Identification of the β TP site in the x-ray structure of F 1 -ATPase as the high-affinity catalytic site
Published in Proceedings of the National Academy of Sciences - PNAS (20-11-2007)“…ATP synthase uses a unique rotary mechanism to couple ATP synthesis and hydrolysis to transmembrane proton translocation. The F 1 subcomplex has three…”
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