Search Results - "MANTOVANI, Giovanna"

Pseudohypoparathyroidism: Diagnosis and Treatment by Mantovani, Giovanna

“…Context: The term pseudohypoparathyroidism (PHP) indicates a group of heterogeneous disorders whose common feature is represented by impaired signaling of…”
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Pseudohypoparathyroidism, acrodysostosis, progressive osseous heteroplasia: different names for the same spectrum of diseases? by Elli, Francesca Marta, Mantovani, Giovanna

“…Pseudohypoparathyroidism (PHP), the first known post-receptorial hormone resistance, derives from a partial deficiency of the α subunit of the stimulatory G…”
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Adrenal Insufficiency at the Time of COVID-19: A Retrospective Study in Patients Referring to a Tertiary Center by Carosi, Giulia, Morelli, Valentina, Del Sindaco, Giulia, Serban, Andreea Liliana, Cremaschi, Arianna, Frigerio, Sofia, Rodari, Giulia, Profka, Eriselda, Indirli, Rita, Mungari, Roberta, Resi, Veronica, Orsi, Emanuela, Ferrante, Emanuele, Dolci, Alessia, Giavoli, Claudia, Arosio, Maura, Mantovani, Giovanna

“…Abstract Context Coronavirus disease 2019 (COVID-19) represents a global health emergency, and infected patients with chronic diseases often present with a…”
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Drug resistance in pituitary tumours: from cell membrane to intracellular signalling by Peverelli, Erika, Treppiedi, Donatella, Mangili, Federica, Catalano, Rosa, Spada, Anna, Mantovani, Giovanna

“…The pharmacological treatment of pituitary tumours is based on the use of stable analogues of somatostatin and dopamine. The analogues bind to somatostatin…”
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The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis by Mattiola, Irene, Tomay, Federica, De Pizzol, Maria, Silva-Gomes, Rita, Savino, Benedetta, Gulic, Tamara, Doni, Andrea, Lonardi, Silvia, Astrid Boutet, Marie, Nerviani, Alessandra, Carriero, Roberta, Molgora, Martina, Stravalaci, Matteo, Morone, Diego, Shalova, Irina N., Lee, Yunquin, Biswas, Subhra K., Mantovani, Giovanna, Sironi, Marina, Pitzalis, Costantino, Vermi, William, Bottazzi, Barbara, Mantovani, Alberto, Locati, Massimo

“…The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was…”
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The association of hypogonadism with depression and its treatments by Indirli, Rita, Lanzi, Valeria, Arosio, Maura, Mantovani, Giovanna, Ferrante, Emanuele

“…According to World Health Organization estimates, 5% of the adult population worldwide suffers from depression. In addition to the affective, psychomotor and…”
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Bone health in functional hypothalamic amenorrhea: What the endocrinologist needs to know by Indirli, Rita, Lanzi, Valeria, Mantovani, Giovanna, Arosio, Maura, Ferrante, Emanuele

“…In the original definition by Klinefelter, Albright and Griswold, the expression “hypothalamic hypoestrogenism” was used to describe functional hypothalamic…”
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Multiple hormone resistance and alterations of G-protein-coupled receptors signaling by Mantovani, Giovanna, Elli, Francesca Marta

“…Metabolic disorders deriving from the non-responsiveness of target organs to hormones, which manifest clinically similar to the deficiency of a given hormone…”
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The Prevalence of GNAS Deficiency-Related Diseases in a Large Cohort of Patients Characterized by the EuroPHP Network by Elli, Francesca Marta, Linglart, Agnès, Garin, Intza, de Sanctis, Luisa, Bordogna, Paolo, Grybek, Virginie, Pereda, Arrate, Giachero, Federica, Verrua, Elisa, Hanna, Patrick, Mantovani, Giovanna, Perez de Nanclares, Guiomar

“…Context: The term pseudohypoparathyroidism (PHP) was coined to describe the clinical condition resulting from end-organ resistance to parathormone (rPTH),…”
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Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane by Jobin, Marie-Lise, Siddig, Sana, Koszegi, Zsombor, Lanoiselée, Yann, Khayenko, Vladimir, Sungkaworn, Titiwat, Werner, Christian, Seier, Kerstin, Misigaiski, Christin, Mantovani, Giovanna, Sauer, Markus, Maric, Hans M., Calebiro, Davide

“…The γ-aminobutyric acid type B (GABA B ) receptor is a prototypical family C G protein-coupled receptor (GPCR) that plays a key role in the regulation of…”
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A complex pheotype in a girl with a novel heterozygous missense variant (p.Ile56Phe) of the GNAS gene by Cavarzere, Paolo, Gastaldi, Andrea, Elli, Francesca Marta, Gaudino, Rossella, Peverelli, Erika, Brugnara, Milena, Thiele, Susanne, Granata, Francesca, Mantovani, Giovanna, Antoniazzi, Franco

“…GNAS is a complex gene that encodes Gsα, a signaling protein that triggers a complex network of pathways. Heterozygous inactivating mutations in Gsα-coding…”
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Prevalence and clinical features of armadillo repeat-containing 5 mutations carriers in a single center cohort of patients with bilateral adrenal incidentalomas by Morelli, Valentina, Elli, Francesca Marta, Frigerio, Sofia, Vena, Walter, Palmieri, Serena, Lucca, Camilla, Maffini, Maria Antonia, Contarino, Andrea, Bagnaresi, Francesca, Mantovani, Giovanna, Arosio, Maura

“…Abstract Objective We aimed to evaluate the prevalence of armadillo repeat-containing 5 (ARMC5) genetic defects in our cohort of bilateral adrenal…”
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Parathyroid hormone resistance syndromes – Inactivating PTH/PTHrP signaling disorders (iPPSDs) by Elli, Francesca Marta, Pereda, Arrate, Linglart, Agnès, Perez de Nanclares, Guiomar, Mantovani, Giovanna

“…Metabolic disorders caused by impairments of the Gsα/cAMP/PKA pathway affecting the signaling of PTH/PTHrP lead to features caused by non-responsiveness of…”
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Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas by Ronchi, Cristina L, Peverelli, Erika, Herterich, Sabine, Weigand, Isabel, Mantovani, Giovanna, Schwarzmayr, Thomas, Sbiera, Silviu, Allolio, Bruno, Honegger, Jürgen, Appenzeller, Silke, Lania, Andrea G, Reincke, Martin, Calebiro, Davide, Spada, Anna, Buchfelder, Michael, Flitsch, Joerg, Strom, Tim M, Fassnacht, Martin

“…ContextAlterations in the cAMP signaling pathway are common in hormonally active endocrine tumors. Somatic mutations at GNAS are causative in 30–40% of…”
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USP8 inhibitor RA-9 reduces ACTH release and cell growth in tumor corticotrophs by Treppiedi, Donatella, Di Muro, Genesio, Marra, Giusy, Barbieri, Anna Maria, Mangili, Federica, Catalano, Rosa, Serban, Andreea, Ferrante, Emanuele, Locatelli, Marco, Lania, Andrea G, Arosio, Maura, Spada, Anna, Peverelli, Erika, Mantovani, Giovanna

“…Cushing’s disease (CD) is a rare endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor. Pasireotide is the only…”
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DXA-derived lumbar bone strain index corrected for kyphosis is associated with vertebral fractures and trabecular bone score in acromegaly by Jaafar, Simona, Cristofolini, Giacomo, Morenghi, Emanuela, Rinaudo, Luca, Birtolo, Maria Francesca, Sala, Elisa, Ferrante, Emanuele, Mungari, Roberta, Lavezzi, Elisabetta, Leonardi, Lorenzo, Ragucci, Pasquala, Ulivieri, Fabio M., Balzarini, Luca, Mantovani, Giovanna, Lania, Andrea G., Mazziotti, Gherardo

“…Purpose The bone strain index (BSI) is a marker of bone deformation based on a finite element analysis inferred from dual X-ray absorptiometry (DXA) scans,…”
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SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome by Bitetto, Giacomo, Lopez, Gianluca, Ronchi, Dario, Pittaro, Alessandra, Melzi, Valentina, Peverelli, Erika, Cribiù, Fulvia Milena, Comi, Giacomo P, Mantovani, Giovanna, Di Fonzo, Alessio

“…Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement. Allgrove disease…”
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Mutations in the Gs alpha gene causing hormone resistance by Mantovani, Giovanna, Spada, Anna

“…G-protein-coupled receptors (GPCRs) and G proteins mediate the effects of a number of hormones of relevance to endocrinology. Genes encoding these molecules…”
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The Novel SSTR3 Agonist ITF2984 Exerts Antimitotic and Proapoptotic Effects in Human Non-Functioning Pituitary Neuroendocrine Tumor (NF-PitNET) Cells by Di Muro, Genesio, Catalano, Rosa, Treppiedi, Donatella, Barbieri, Anna Maria, Mangili, Federica, Marra, Giusy, Di Bari, Sonia, Esposito, Emanuela, Nozza, Emma, Lania, Andrea G, Ferrante, Emanuele, Locatelli, Marco, Modena, Daniela, Steinkuhler, Christian, Peverelli, Erika, Mantovani, Giovanna

“…Somatostatin receptor ligands (SRLs) with high affinity for somatostatin receptors 2 and 5 (SSTR2 and SSTR5) are poorly efficacious in NF-PitNETs, expressing…”
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cAMP in the pituitary: an old messenger for multiple signals by Peverelli, Erika, Mantovani, Giovanna, Lania, Andrea G, Spada, Anna

“…The cyclic nucleotide cAMP is a universal regulator of a variety of cell functions in response to activated G-protein coupled receptors. In particular, cAMP…”
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