Search Results - "MANTHEY, IRIS"

Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site by Stegen, Maike, Engler, Andrea, Ochsenfarth, Crista, Manthey, Iris, Peters, Jürgen, Siffert, Winfried, Frey, Ulrich H

“…G protein-coupled receptor kinase 6 (GRK6) is part of the G protein-coupled receptor kinase family, whose members act as key regulators of seven-transmembrane…”
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Characterization of the promoter of the human farnesyltransferase beta subunit and the impact of the transcription factor OCT-1 on its expression by Verhasselt, Henning, Stelmach, Patrick, Domin, Marie, Jung, Dominik, Hagemann, Anna, Manthey, Iris, Bachmann, Hagen S.

“…Farnesyltransferase (FTase) enables about 100 proteins to interact with cellular membranes by catalyzing the posttranslational addition of a farnesyl group…”
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Exploring the putative self‐binding property of the human farnesyltransferase alpha‐subunit by Hagemann, Anna, Müller, Grit, Manthey, Iris, Bachmann, Hagen S.

“…Farnesylation is an important post‐translational protein modification in eukaryotes. Farnesylation is performed by protein farnesyltransferase, a heterodimer…”
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Identification and characterization of Gbeta3s2, a novel splice variant of the G-protein beta3 subunit by ROSSKOPF, Dieter, MANTHEY, Iris, HABICH, Christiane, KIELBIK, Marzena, EISENHARDT, Andreas, NIKULA, Christiane, URBAN, Melanie, KOHNEN, Stefanie, GRAF, Eva, RAVENS, Ursula, SIFFERT, Winfried

“…The T-allele of a polymorphism (C825T) in the gene for the G-protein β3 subunit (GNB3) is associated with cardiovascular and metabolic disorders, distinct…”
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Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery by Danowski, Nina, Manthey, Iris, Jakob, Heinz Günther, Siffert, Winfried, Peters, Jürgen, Frey, Ulrich H

“…Coronary artery disease (CAD)-associated ischemic heart failure is characterized by dysregulated gene expression which is partly mediated by microRNAs…”
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G Protein β3 Gene: Structure, Promoter, and Additional Polymorphisms by Rosskopf, Dieter, Busch, Stefan, Manthey, Iris, Siffert, Winfried

“…Recent studies have shown that a polymorphism (C825T) in the gene encoding the G protein β3 subunit (GNB3) is associated with hypertension and obesity. We…”
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A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Gαs protein expression and body weight regulation by Frey, Ulrich H, Hauner, Hans, Jöckel, Karl-Heinz, Manthey, Iris, Brockmeyer, Norbert, Siffert, Winfried

“…OBJECTIVESBody weight regulation is under complex control involving the central nervous system and peripheral pathways. The β-adrenoceptor Gαs protein system…”
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A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome by Klenke, Stefanie, Tan, Susanne, Hahn, Susanne, Mann, Klaus, Hauner, Hans, Manthey, Iris, Peters, Jürgen, Siffert, Winfried, Frey, Ulrich H

“…OBJECTIVESThe G-protein Gq, encoded by GNAQ, is involved in glucose metabolism. The GNAQ promoter harbours three polymorphisms. The TT(−695/−694)GC…”
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A novel functional haplotype in the human GNAS gene alters Gαs expression, responsiveness to β-adrenoceptor stimulation, and peri-operative cardiac performance by Frey, Ulrich H., Adamzik, Michael, Kottenberg-Assenmacher, Eva, Jakob, Heinz, Manthey, Iris, Broecker-Preuss, Martina, Bergmann, Lars, Heusch, Gerd, Siffert, Winfried, Peters, Jürgen, Leineweber, Kirsten

“…Aims Cardiac overexpression of the β-adrenoceptor-coupled G-protein subunit Gαs in mice enhances inotropic responses to sympathetic stimulation, but evokes…”
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Decreased expression of microRNA miR‐133 but not miR‐1 is associated with impaired cardiac performance by Danowski, Nina, Frey, Ulrich, Kottenberg‐Assenmacher, Eva, Jakob, Heinz Günther, Manthey, Iris, Siffert, Winfried, Peters, Jürgen

“…Abstract only MicroRNAs (miRs) post‐transcriptionally regulate gene expression. miR‐1 and miR‐133 can evoke opposing effects on apoptosis in cardiomyocytes…”
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A novel functional haplotype in the human GNAS gene alters G[alpha]s expression, responsiveness to [beta]-adrenoceptor stimulation, and peri-operative cardiac performance by Frey, Ulrich H, Adamzik, Michael, Kottenberg-assenmacher, Eva, Heinz Jakob, Manthey, Iris, Broecker-preuss, Martina, Bergmann, Lars, Heusch, Gerd, Siffert, Winfried, Peters, Jürgen, Leineweber, Kirsten

“…Aims Cardiac overexpression of the β-adrenoceptor-coupled G-protein subunit Gαs in mice enhances inotropic responses to sympathetic stimulation, but evokes…”
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A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Galphas protein expression and body weight regulation by Frey, Ulrich H, Hauner, Hans, Jöckel, Karl-Heinz, Manthey, Iris, Brockmeyer, Norbert, Siffert, Winfried

“…Body weight regulation is under complex control involving the central nervous system and peripheral pathways. The beta-adrenoceptor Galphas protein system…”
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The human G protein β4 subunit: gene structure, expression, Gγ and effector interaction by Rosskopf, Dieter, Nikula, Christiane, Manthey, Iris, Joisten, Markus, Frey, Ulrich, Kohnen, Stefanie, Siffert, Winfried

“…The aim of this study was the characterization of the human Gβ4 subunit of heterotrimeric G proteins. Human Gβ4 is widely expressed. Its gene is located on…”
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Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein ß3 subunit by Rosskopf, Dieter, Manthey, Iris, Siffert, Winfried

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Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit by Rosskopf, Dieter, Manthey, Iris, Habich, Christiane, Kielbik, Marzena, Eisenhardt, Andreas, Nikula, Christiane, Urban, Melanie, Kohnen, Stefanie, Graf, Eva, Ravens, Ursula, Siffert, Winfried

“…The T-allele of a polymorphism (C825T) in the gene for the G-protein beta 3 subunit (GNB3) is associated with cardiovascular and metabolic disorders, distinct…”
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Signal transduction of somatostatin in human B lymphoblasts by Rosskopf, Dieter, Schürks, Markus, Manthey, Iris, Joisten, Markus, Busch, Stefan, Siffert, Winfried

“…Somatostatin (SST) and somatostatin receptors (SSTR) are widely distributed in lymphoid tissues. Here, we report on the stimulatory effects of SST in…”
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The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction by Rosskopf, Dieter, Nikula, Christiane, Manthey, Iris, Joisten, Markus, Frey, Ulrich, Kohnen, Stefanie, Siffert, Winfried

“…The aim of this study was the characterization of the human Gbeta4 subunit of heterotrimeric G proteins. Human Gbeta4 is widely expressed. Its gene is located…”
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G protein (beta)3 gene: Structure, promoter, and additional polymorphisms by Rosskopf, Dieter, Busch, Stefan, Manthey, Iris, Siffert, Winfried

“…Recent studies have shown that a polymorphism (C825T) in the gene encoding the G protein beta 3 subunit (GNB3) is associated with hypertension and obesity. We…”
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A novel functional haplotype in the human GNAS gene alters Galphas expression, responsiveness to beta-adrenoceptor stimulation, and peri-operative cardiac performance by Frey, Ulrich H, Adamzik, Michael, Kottenberg-Assenmacher, Eva, Jakob, Heinz, Manthey, Iris, Broecker-Preuss, Martina, Bergmann, Lars, Heusch, Gerd, Siffert, Winfried, Peters, Jürgen, Leineweber, Kirsten

“…Cardiac overexpression of the beta-adrenoceptor-coupled G-protein subunit Galphas in mice enhances inotropic responses to sympathetic stimulation, but evokes…”
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Quantification of G protein Gaalphas subunit splice variants in different human tissues and cells using pyrosequencing by Frey, Ulrich H, Nückel, Holger, Dobrev, Dobromir, Manthey, Iris, Sandalcioglu, I E, Eisenhardt, Andreas, Worm, Karl, Hauner, Hans, Siffert, Winfried

“…The G protein Galphas is derived from four alternatively spliced transcripts, two long variants (Galphas(L)+CAG and Galphas(L)-CAG), which include an extra…”
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