Search Results - "MANSUR, ADEL"

Clinical utility of fractional exhaled nitric oxide in severe asthma management by Menzies-Gow, Andrew, Mansur, Adel H, Brightling, Christopher E

“…Asthma is a chronic inflammatory disease of the airways, affecting over 350 million people worldwide and placing a significant burden on healthcare providers…”
Get full text

Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry by Sweeney, Joan, Patterson, Chris C, Menzies-Gow, Andrew, Niven, Rob M, Mansur, Adel H, Bucknall, Christine, Chaudhuri, Rekha, Price, David, Brightling, Chris E, Heaney, Liam G

“…To determine the prevalence of systemic corticosteroid-induced morbidity in severe asthma. Cross-sectional observational study. The primary care Optimum…”
Get more information

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma by Heaney, Liam G, Busby, John, Bradding, Peter, Chaudhuri, Rekha, Mansur, Adel H, Niven, Robert, Pavord, Ian D, Lindsay, John T, Costello, Richard W

“…Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS)…”
Get full text

Disconnect of type 2 biomarkers in severe asthma; dominated by FeNO as a predictor of exacerbations and periostin as predictor of reduced lung function by Mansur, Adel H., Srivastava, Sapna, Sahal, Adeel

“…biomarkers of Type 2 (T2) inflammation may predict asthma control and exacerbation risk. However, the relationships between individual T2 biomarkers to…”
Get full text

Dedicated Severe Asthma Services Improve Health-care Use and Quality of Life by Gibeon, David, MBChB, Heaney, Liam G., MD, Brightling, Chris E., PhD, FCCP, Niven, Rob, MD, Mansur, Adel H., PhD, Chaudhuri, Rekha, MD, Bucknall, Christine E., MD, Menzies-Gow, Andrew N., PhD

“…BACKGROUND Systematic assessment of severe asthma can be used to confirm the diagnosis identify comorbidities, and address adherence to therapy. However, the…”
Get full text

Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era by Jackson, David J, Busby, John, Pfeffer, Paul E, Menzies-Gow, Andrew, Brown, Thomas, Gore, Robin, Doherty, Martin, Mansur, Adel H, Message, Simon, Niven, Robert, Patel, Mitesh, Heaney, Liam G

“…The UK Severe Asthma Registry (UKSAR) is the world's largest national severe asthma registry collecting standardised data on referrals to UK specialist…”
Get more information

Longterm clinical outcomes of omalizumab therapy in severe allergic asthma: Study of efficacy and safety by Mansur, Adel H, Srivastava, Sapna, Mitchell, Verity, Sullivan, Julie, Kasujee, Ismail

“…Abstract Omalizumab has been shown to be an effective add-on therapy for patients with uncontrolled severe persistent allergic asthma. There has been a steady…”
Get full text

Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial by Gonem, Sherif, PhD, Berair, Rachid, MBChB, Singapuri, Amisha, BSc, Hartley, Ruth, MBChB, Laurencin, Marie F M, BSc, Bacher, Gerald, PhD, Holzhauer, Björn, Dipl Math, Bourne, Michelle, BSc, Mistry, Vijay, BSc, Pavord, Ian D, Prof, Mansur, Adel H, PhD, Wardlaw, Andrew J, Prof, Siddiqui, Salman H, Prof, Kay, Richard A, PhD, Brightling, Christopher E, Prof

“…Summary Background Eosinophilic airway inflammation is often present in asthma, and reduction of such inflammation results in improved clinical outcomes. We…”
Get full text

Development and Clinical Application of a Prednisolone/Cortisol Assay to Determine Adherence to Maintenance Oral Prednisolone in Severe Asthma by Mansur, Adel H., Hassan, Maged, Duffy, Joanne, Webster, Craig

“…Nonadherence to oral prednisolone is an important driver of poor control in severe asthma, and its detection is warranted to guide management. The goal of this…”
Get full text

A Charter to Fundamentally Change the Role of Oral Corticosteroids in the Management of Asthma by Haughney, John, Winders, Tonya, Holmes, Steve, Chanez, Pascal, Menzies-Gow, Andrew, Kocks, Janwillem, Mansur, Adel H., McPherson, Christopher, Canonica, Giorgio Walter

“…Asthma affects 339 million people worldwide, with an estimated 5–10% experiencing severe asthma. In emergency settings, oral corticosteroids (OCS) can be…”
Get full text

In vitro , in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss by Chernyavsky, Igor L, Russell, Richard J, Saunders, Ruth M, Morris, Gavin E, Berair, Rachid, Singapuri, Amisha, Chachi, Latifa, Mansur, Adel H, Howarth, Peter H, Dennison, Patrick, Chaudhuri, Rekha, Bicknell, Stephen, Rose, Felicity R A J, Siddiqui, Salman, Brook, Bindi S, Brightling, Christopher E

“…Bronchial thermoplasty is a treatment for asthma. It is currently unclear whether its histopathological impact is sufficiently explained by the proportion of…”
Get full text

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study by Shrine, Nick, Portelli, Michael A, John, Catherine, Soler Artigas, María, Bennett, Neil, Hall, Robert, Lewis, Jon, Henry, Amanda P, Billington, Charlotte K, Ahmad, Azaz, Packer, Richard J, Shaw, Dominick, Pogson, Zara E K, Fogarty, Andrew, McKeever, Tricia M, Singapuri, Amisha, Heaney, Liam G, Mansur, Adel H, Chaudhuri, Rekha, Thomson, Neil C, Holloway, John W, Lockett, Gabrielle A, Howarth, Peter H, Djukanovic, Ratko, Hankinson, Jenny, Niven, Robert, Simpson, Angela, Chung, Kian Fan, Sterk, Peter J, Blakey, John D, Adcock, Ian M, Hu, Sile, Guo, Yike, Obeidat, Maen, Sin, Don D, van den Berge, Maarten, Nickle, David C, Bossé, Yohan, Tobin, Martin D, Hall, Ian P, Brightling, Christopher E, Wain, Louise V, Sayers, Ian

“…Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see…”
Get full text

Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma by Couillard, Simon, Shrimanker, Rahul, Chaudhuri, Rekha, Mansur, Adel H, McGarvey, Lorcan P, Heaney, Liam G, Fowler, Stephen J, Bradding, Peter, Pavord, Ian D, Hinks, Timothy S C

Get full text

Exploring facilitators and barriers in asthma management in rural, semi‐urban and urban populations in Vellore, India: An interview study of patients and primary care physicians by Williams, Iestyn, Daniel, Jefferson, Mansur, Adel H., Christopher, Devasahayam Jesudas, Krishna, Mamidipudi Thirumala

Get full text

Fevipiprant, a prostaglandin D 2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial by Gonem, Sherif, Berair, Rachid, Singapuri, Amisha, Hartley, Ruth, Laurencin, Marie F M, Bacher, Gerald, Holzhauer, Björn, Bourne, Michelle, Mistry, Vijay, Pavord, Ian D, Mansur, Adel H, Wardlaw, Andrew J, Siddiqui, Salman H, Kay, Richard A, Brightling, Christopher E

Get full text

Post-hospitalisation asthma management in primary care: a retrospective cohort study by Punyadasa, Dhanusha, Simms-Williams, Nikita, Adderley, Nicola J, Thayakaran, Rasiah, Mansur, Adel H, Nirantharakumar, Krishnarajah, Nagakumar, Prasad, Haroon, Shamil

“…Clinical guidelines recommend that patients admitted to hospital for asthma attacks are reviewed in primary care following hospital discharge. To evaluate…”
Get more information

The clinical effectiveness of mepolizumab treatment in severe eosinophilic asthma; outcomes from four years cohort evaluation by Reilly, Christopher, Raja, Anandavelu, Anilkumar, Pillai, Sullivan, Julie, White, Lisa, Bahron, Ali, Marsh, Julie, Mansur, Adel H

“…Clinical trials and real world studies demonstrated benefit of mepolizumab treatment in severe asthma but data on its effectiveness beyond 2 years remain…”
Get full text

Prevalence and predictors of adherence to controller therapy in adult patients with severe/difficult-to-treat asthma: a systematic review and meta-analysis by Hassan, Maged, Davies, Sarah E., Trethewey, Samuel P., Mansur, Adel H.

“…Objective: Nonadherence to prescribed treatment is an important cause for poor asthma control. This systematic review aimed to determine the prevalence and…”
Get full text

Management of difficult-to-treat asthma in adolescence and young adults by Mansur, Adel H, Prasad, Nagakumar

“…The period of adolescence and young adulthood (AYA) has been proposed to extend from 11 to 25 years of age as patients in this age group face similar…”
Get full text

Biomarkers of oxidative stress and antioxidants in severe asthma: A Prospective Case-Control Study by Bishopp, Abigail, Sathyamurthy, Ramamurthy, Manney, Sarah, Webbster, Craig, Krishna, Mamidipudi Thirumala, Mansur, Adel H

“…Bronchial airway inflammation is the hallmark of asthma, which may be driven by an imbalance between oxidative stress and antioxidant defenses. Antioxidants…”
Get full text