Search Results - "MANS, D. R. A"

Monitoring the response of patients with cutaneous leishmaniasis to treatment with pentamidine isethionate by quantitative real-time PCR, and identification of Leishmania parasites not responding to therapy by Mans, D. R. A., Kent, A. D., Hu, R. V., Lai A. Fat, E. J., Schoone, G. J., Adams, E. R., Rood, E. J., Alba, S., Sabajo, L. O. A., Lai A Fat, R. F., de Vries, H. J. C., Schallig, H. D. F. H.

“…Summary Background Leishmania (Viannia) guyanensis is believed to be the principal cause of cutaneous leishmaniasis (CL) in Suriname. This disease is treated…”
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In vitro evaluation of traditionally used Surinamese medicinal plants for their potential anti-leishmanial efficacy by Mans, D.R.A., Beerens, T., Magali, I., Soekhoe, R.C., Schoone, G.J., Oedairadjsingh, K., Hasrat, J.A., van den Bogaart, E., Schallig, H.D.F.H.

“…Plant-based preparations are extensively used in Surinamese folk medicine for treating leishmaniasis, but often without a scientific rationale. To evaluate 25…”
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Targeting Protein Kinase C: New Therapeutic Opportunities Against High‐Grade Malignant Gliomas? by da Rocha, A. B., Mans, D.R.A., Regner, A., Schwartsmann, G.

“…Learning Objectives After completing this course, the reader should be able to: Understand protein kinase C (PKC) in signal transduction pathways. Understand…”
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Incidence, and gender, age and ethnic distribution of sarcomas in the republic of suriname from 1980 to 2008 by Mans, D Ra, Budhu Lall, A E, Macnack, V L, van Tholl, J A, Zandveld, E B, Vrede, M A

“…We report on the incidence and the gender, age, and ethnic distribution of sarcomas diagnosed between 1980 and 2008 in the multi-ethnic Republic of Suriname…”
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Partial purification of (a) low molecular weight ovine pineal compound(s) with an inhibiting effect on the growth of human melanoma cells in vitro by NOTEBORN, H. P. J. M, BARTSCH, H, BARTSCH, C, MANS, D. R. A, WEUSTEN, J. J. A. M, FLEHMIG, B, EBELS, I, SALEMINK, C. A

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Sequence-dependent growth inhibition and DNA damage formation by the irinotecan–5-fluorouracil combination in human colon carcinoma cell lines by Mans, D.R.A., Grivicich, I., Peters, G.J., Schwartsmann, G.

“…We evaluated irinotecan (CPT-11) together with 5-fluorouracil (5-FU) for improved cell growth inhibition with respect to that by either agent alone in the…”
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Spasmogenic effect of a Solanum melongena leaf extract on guinea pig tracheal chains and its possible mechanism(s) by Mans, D.R.A., Toelsie, J., Mohan, S., Jurgens, S., Muhringen, M., Illes, S., Macnack, R., Bipat, R.

“…The methanol extract of fresh leaves of Solanum melongena L. (Solanaceae) was evaluated for its capacity to alter the tone of isolated, pre-contracted guinea…”
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Spasmogenic effect of a Solanummelongena leaf extract on guinea pig tracheal chains and its possible mechanism(s) by Mans, D R A, Toelsie, J, Mohan, S, Jurgens, S, Muhringen, M, Illes, S, Macnack, R, Bipat, R

“…The methanol extract of fresh leaves of Solanum melongena L. (Solanaceae) was evaluated for its capacity to alter the tone of isolated, pre-contracted guinea…”
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Daily and seasonal rhythmicity in the methylation of pineal indolic compounds in adult male golden hamsters, kept under natural conditions by VAN BENTHEM, J, MANS, D. R. A, HALDAR-MISRA, C, EBELS, I, BALEMANS, M. G. M

“…Seasonal rhythmicity in the reproductive cycle was demonstrated in golden hamsters exposed to natural conditions. Testes regress in weight and function from…”
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Rhythmic synthesis of various 5-methoxyindoles in the pineal gland of male adult golden hamsters, kept under the same artificial conditions throughout the year by VAN BENTHEM, J, MANS, D. R. A, EBELS, I, BALEMANS, M. G. M

“…Until now the day/night and seasonal rhythmicity in the synthesis of 5-methoxyindoles (MI) is thought to be regulated by environmental factors, especially…”
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The effect of reduced neopterin on the synthesis of several methylated indoles in the pineal gland of adult male golden hamsters, kept under standardized conditions by VAN BENTHEM, J, EBELS, I, BALEMANS, M. G. M, DE MOREE, A, MANS, D. R. A

“…In the present study the effect was tested of reduced neopterin (RN) on the methylating capacity of the pineal gland of adult, male golden hamsters, housed…”
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Tamoxifen inhibits particulate-associated protein kinase C activity, and sensitises cultured human glioblastoma cells not to etoposide but to γ-radiation and BCNU by Brondani da Rocha, A, Mans, D.R.A, Bernard, E.A, Ruschel, C, Logullo, A.F, Wetmore, L.A, Leyva, A, Schwartsmann, G

“…We investigated the potential mechanisms of tamoxifen cytotoxicity in the U-373, U-138, and U-87 human glioblastoma cell lines, namely interference with…”
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Clinical and pharmacokinetic study of oral etoposide in patients with AIDS-related Kaposi's sarcoma with no prior exposure to cytotoxic therapy by Schwartsmann, G, Sprinz, E, Kromfield, M, Kalakun, L, Sander, E, Prolla, G, Di Leone, L, Gerhardt, L, Mans, D R

“…In this phase II and pharmacokinetic study, chronic, low-dose, oral etoposide was evaluated for its efficacy in patients with AIDS-related Kaposi's sarcoma who…”
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Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation by Mans, D R, Lafleur, M V, Westmijze, E J, Horn, I R, Bets, D, Schuurhuis, G J, Lankelma, J, Retèl, J

“…Etoposide [4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta- D-glucopyranoside)] can be metabolized to DNA-inactivating catechol, ortho-quinone and…”
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Formation of different reaction products with single- and double-stranded DNA by the ortho-quinone and the semi-quinone free radical of etoposide (VP-16-213) by Mans, D R, Lafleur, M V, Westmijze, E J, van Maanen, J M, van Schaik, M A, Lankelma, J, Retèl, J

“…In this report, the types of DNA damage introduced by the ortho-quinone and the semiquinone free radical of…”
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Intrathecal administration of etoposide in the treatment of malignant meningitis : feasibility and pharmacokinetic data by VAN DER GAAST, A, SONNEVELD, P, MANS, D. R. A, SPLINTER, T. A. W

“…Two patients presenting with malignant meningitis resulting from small-cell carcinoma of the lung and with lymphoblastic leukemia, respectively, were treated…”
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Effects of the ortho-quinone and catechol of the antitumor drug VP-16-213 on the biological activity of single-stranded and double-stranded phi X174 DNA by van Maanen, J M, Lafleur, M V, Mans, D R, van den Akker, E, de Ruiter, C, Kootstra, P R, Pappie, D, de Vries, J, Retèl, J, Pinedo, H M

“…We have studied the effects of the recently reported two new metabolites of the antitumor agent VP-16-213, the ortho-dihydroxy derivative or catechol and the…”
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Two new cases of hyperpyrimidinuria associated with excessive 5-fluorouracil toxicity by Mans, D R, Scaletzky, A, Becker, D, de Oliveria, J R, Pinheiro, C M, Bittar, C, Ferreira Filho, A, Machado, V L, Ritt, J L, Jung, F A

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Effects of oxygen radical scavengers on the inactivation of SS phi X174 DNA by the semi-quinone free radical of the antitumor agent etoposide by Van Maanen, J M, Mans, D R, Lafleur, M V, Van Schaik, M A, de Vries, J, Vermeulen, N P, Retèl, J, Lankelma, J

“…We have studied the effects of oxygen radical scavengers on the inactivation of ss phi X174 DNA by the semi-quinone free radical of the antitumor agent…”
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Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded ΦX174 DNA by MANS, D. R. A, RETEL, J, VAN MAANEN, J. M. S, LAFLEUR, M. V. M, VAN SCHAIK, M. A, PINEDO, H. M, LANKELMA, J

“…The mechanism of action of the anti-tumour agent etoposide (VP-16-213) could involve its bioactivation to metabolites which can damage DNA. Active metabolites…”
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