Verapamil-induced changes in digoxin kinetics in cirrhosis

Verapamil-induced changes in digoxin kinetics in cirrhosis

The influence of a single low dose of verapamil (80 mg) on the serum levels of digoxin (single dose of 0.5 mg) was studied in 6 patients with hepatic cirrhosis and in 6 healthy volunteer controls. In the cirrhotic patients verapamil increased the peak serum level and the total AUC of digoxin by 98%...

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Bibliographic Details
Published in:European journal of clinical pharmacology Vol. 32; no. 3; pp. 309 - 311
Main Authors: MARAGNO, I, GIANOTTI, C, TROPEANO, P. F, RODIGHIERO, V, GAION, R. M, PALEARI, C, PRANDONI, R, MANOZZI, L
Format: Journal Article
Language:English
Published: Heidelberg Springer 01-01-1987
Berlin
Subjects:
Adult
Aged
Biological and medical sciences
Cardiotonic agents
Cardiovascular system
Digoxin - blood
Drug Interactions
Female
Humans
Kinetics
Liver Cirrhosis - blood
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Verapamil - pharmacology
Human
Drug combination
Cardiotonic agent
Calcium antagonist
Single dose
Oral administration
Hepatobiliary disease
Normal
Cirrhosis
Serum
Drug interaction
Pharmacokinetics
Comparative study
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Summary:The influence of a single low dose of verapamil (80 mg) on the serum levels of digoxin (single dose of 0.5 mg) was studied in 6 patients with hepatic cirrhosis and in 6 healthy volunteer controls. In the cirrhotic patients verapamil increased the peak serum level and the total AUC of digoxin by 98% and 32%, respectively. There was an associated 23% decrease in the renal digoxin clearance. In normal subjects only marginal alterations in digoxin kinetics were observed following verapamil administration. The results indicate that cirrhosis magnifies the influence of verapamil on digoxin kinetics.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00607580