Search Results - "MANNS, M."

Treating viral hepatitis C: efficacy, side effects, and complications by Manns, M P, Wedemeyer, H, Cornberg, M

“…The treatment of hepatitis C has dramatically improved over the past decade. Unlike any other chronic viral infection, a significant proportion of patients…”
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Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC‐Specific Chimeric Antigen Receptor by Noyan, F., Zimmermann, K., Hardtke‐Wolenski, M., Knoefel, A., Schulde, E., Geffers, R., Hust, M., Huehn, J., Galla, M., Morgan, M., Jokuszies, A., Manns, M. P., Jaeckel, E.

“…CD4+CD25highFOXP3+ regulatory T cells (Tregs) are involved in graft‐specific tolerance after solid organ transplantation. However, adoptive transfer of…”
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Endoscopic closure of esophageal intrathoracic leaks: stent versus endoscopic vacuum-assisted closure, a retrospective analysis by Brangewitz, M, Voigtländer, T, Helfritz, F A, Lankisch, T O, Winkler, M, Klempnauer, J, Manns, M P, Schneider, A S, Wedemeyer, J

“…Placement of covered self-expanding metal or plastic stents (SEMS or SEPS) is an established method for managing intrathoracic leaks. Recently, endoscopic…”
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Interferon‐free therapy of chronic hepatitis C with direct‐acting antivirals does not change the short‐term risk for de novo hepatocellular carcinoma in patients with liver cirrhosis by Mettke, F., Schlevogt, B., Deterding, K., Wranke, A., Smith, A., Port, K., Manns, M. P., Vogel, A., Cornberg, M., Wedemeyer, H.

“…Summary Background Hepatitis C virus (HCV) clearance with IFN‐based therapies reduces the incidence of hepatocellular carcinoma (HCC). There has been some…”
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Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial by Ratziu, V., de Guevara, L., Safadi, R., Poordad, F., Fuster, F., Flores-Figueroa, J., Arrese, M., Fracanzani, Anna L., Ben Bashat, D., Lackner, K., Gorfine, T., Kadosh, S., Oren, R., Halperin, M., Hayardeny, L., Loomba, R., Friedman, S., Sanyal, Arun J.

“…Nonalcoholic steatohepatitis (NASH), a chronic liver disease without an approved therapy, is associated with lipotoxicity and insulin resistance and is a major…”
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The impact of the revolution in hepatitis C treatment on hepatocellular carcinoma by Wirth, T.C., Manns, M.P.

“…Hepatitis C infection represents a global health problem affecting ∼200 million chronically infected patients worldwide. Owing to the development of a…”
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Improvement of liver function parameters in advanced HCV‐associated liver cirrhosis by IFN‐free antiviral therapies by Deterding, K., Höner zu Siederdissen, C., Port, K., Solbach, P., Sollik, L., Kirschner, J., Mix, C., Cornberg, J., Worzala, D., Mix, H., Manns, M. P., Cornberg, M., Wedemeyer, H.

“…Summary Background Successful antiviral treatment of decompensated hepatitis B with HBV polymerase inhibitors is associated with improvement of liver function…”
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Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected with genotypes A and D by Maasoumy, B., Wiegand, S.B., Jaroszewicz, J., Bremer, B., Lehmann, P., Deterding, K., Taranta, A., Manns, M.P., Wedemeyer, H., Glebe, D., Cornberg, M.

“…Hepatitis B core-related antigen (HBcrAg) has been suggested as an additional marker of hepatitis B virus (HBV) infection. HBcrAg combines the antigenic…”
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Chronic Hepatitis E in Heart Transplant Recipients by Pischke, S., Stiefel, P., Franz, B., Bremer, B., Suneetha, P. V., Heim, A., Ganzenmueller, T., Schlue, J., Horn‐Wichmann, R., Raupach, R., Darnedde, M., Scheibner, Y., Taubert, R., Haverich, A., Manns, M. P., Wedemeyer, H., Bara, C. L.

“…Chronic courses of hepatitis E virus (HEV) infections have been described in immunosuppressed patients. We aimed to study the role of HEV infections in heart…”
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Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection by Wandrer, F., Han, B., Liebig, S., Schlue, J., Manns, M. P., Schulze‐Osthoff, K., Bantel, H.

“…Summary Background Chronic viral hepatitis is linked to fibrotic liver injury that can progress to liver cirrhosis with its associated complications. Recent…”
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Secondary sclerosing cholangitis in critically ill patients: model of end-stage liver disease score and renal function predict outcome by Voigtländer, T, Negm, A A, Schneider, A S, Strassburg, C P, Manns, M P, Wedemeyer, J, Lankisch, T O

“…Secondary sclerosing cholangitis in critically ill patients (SSC - CIP) is an underdiagnosed emerging disease. The aim of this study was to characterize…”
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Future Organization of Clinical Research in Germany: The Road to the "German Centre for Digestive Health" (GCDH) by Manns, M P

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The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference by Hatzakis, A., Wait, S., Bruix, J., Buti, M., Carballo, M., Cavaleri, M., Colombo, M., Delarocque-Astagneau, E., Dusheiko, G., Esmat, G., Esteban, R., Goldberg, D., Gore, C., Lok, A. S. F., Manns, M., Marcellin, P., Papatheodoridis, G., Peterle, A., Prati, D., Piorkowsky, N., Rizzetto, M., Roudot-Thoraval, F., Soriano, V., Thomas, H. C., Thursz, M., Valla, D., van Damme, P., Veldhuijzen, I. K., Wedemeyer, H., Wiessing, L., Zanetti, A. R., Janssen, H. L. A.

“…Worldwide, the hepatitis B virus (HBV) and the hepatitis C virus (HCV) cause, respectively, 600 000 and 350 000 deaths each year. Viral hepatitis is the…”
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Liver stiffness measurement using acoustic radiation force impulse elastography in overweight and obese patients by Attia, D., Bantel, H., Lenzen, H., Manns, M. P., Gebel, M. J., Potthoff, A.

“…Summary Background Obesity and overweight are global health problems. Aim To evaluate the diagnostic accuracy of liver stiffness measurement (LSM) using…”
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All‐oral direct‐acting antiviral therapy in HCV‐advanced liver disease is effective in real‐world practice: observations through HCV‐TARGET database by Reddy, K. R., Lim, J. K., Kuo, A., Di Bisceglie, A. M., Galati, J. S., Morelli, G., Everson, G. T., Kwo, P. Y., Brown, R. S., Sulkowski, M. S., Akuschevich, L., Lok, A. S., Pockros, P. J., Vainorius, M., Terrault, N. A., Nelson, D. R., Fried, M. W., Manns, M. P.

“…Summary Background Chronic hepatitis C virus therapy in patients with advanced liver disease remains a clinical challenge. HCV‐TARGET collects data in patients…”
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The road map toward an hepatitis C virus‐free transplant population by Berenguer, M., Agarwal, K., Burra, P., Manns, M., Samuel, D.

“…Antiviral therapy to eradicate hepatitis C virus (HCV) infection improves outcomes in patients undergoing liver transplantation (LT) for advanced chronic HCV…”
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Rates of sustained virological response 12 weeks after the scheduled end of direct‐acting antiviral (DAA)‐based hepatitis C virus (HCV) therapy from the National German HCV registry: does HIV coinfection impair the response to DAA combination therapy? by Bischoff, J, Mauss, S, Cordes, C, Lutz, T, Scholten, S, Moll, A, Jäger, H, Cornberg, M, Manns, MP, Baumgarten, A, Rockstroh, JK

“…Objectives The European Association for the Study of the Liver (EASL) treatment recommendations for hepatitis C no longer discriminate between HIV/hepatitis C…”
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Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated by Taubert, R., Danger, R., Londoño, M.‐C., Christakoudi, S., Martinez‐Picola, M., Rimola, A., Manns, M. P., Sánchez‐Fueyo, A., Jaeckel, E.

“…Immunosuppression can be discontinued from selected and stable patients after liver transplantation resulting in spontaneous operational tolerance (SOT),…”
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Survival rate in patients with hepatocellular carcinoma: a retrospective analysis of 389 patients by GRETEN, T. F, PAPENDORF, F, BLECK, J. S, KIRCHHOFF, T, WOHLBEREDT, T, KUBICKA, S, KLEMPNAUER, J, GALANSKI, M, MANNS, M. P

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. However, treatment options are limited and often inefficient. The aim of this study…”
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PD-L1 Checkpoint Inhibition Narrows the Antigen-Specific T Cell Receptor Repertoire in Chronic Lymphocytic Choriomeningitis Virus Infection by Klein, S, Ghersi, D, Manns, M P, Prinz, I, Cornberg, M, Kraft, A R M

“…Checkpoint inhibitors are effective in restoring exhausted CD8 T cell responses in persistent viral infections or tumors. Several compounds are in clinical use…”
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