Search Results - "MANNE, V"

O142 CLOSTRIDIUM DIFFICILE INFECTION AND ALCOHOLIC HEPATITIS: THE ASSOCIATED RISK, MORTALITY, AND HEALTH CARE UTILIZATION by Sundaram, V, May, F.P, Manne, V, Saab, S

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Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon by Duysen, E G, Parikh, K, Aleti, V, Manne, V, Lockridge, O, Chilukuri, N

“…Human paraoxonase1 (hPON1) is a potential therapeutic against the toxicity of organophosphorus (OP) pesticides and chemical warfare nerve agents. We tested…”
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P922 USE OF BOCEPREVIR IN LIVER TRANSPLANT RECIPIENTS: PRELIMINARY ANALYSIS by Saab, S, Manne, V, Bau, S. Sherona, Reynolds, J, Goldstein, L, Durazo, F, El-Kabany, M, Han, S, Busuttil, R

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Discovery of (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity by Hunt, John T, Ding, Charles Z, Batorsky, Roberta, Bednarz, Mark, Bhide, Rajeev, Cho, Young, Chong, Saeho, Chao, Sam, Gullo-Brown, Johnni, Guo, Peng, Kim, Soong Hoon, Lee, Francis Y. F, Leftheris, Katerina, Miller, Arthur, Mitt, Toomas, Patel, Manorama, Penhallow, Becky A, Ricca, Carol, Rose, William C, Schmidt, Robert, Slusarchyk, William A, Vite, Gregory, Manne, Veeraswamy

“…Continuing structure−activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors…”
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A Novel Charge Recycling Design Scheme Based on Adiabatic Charge Pump by Ka-Ming Keung, Manne, V., Tyagi, A.

“…Power consumption has become a critical design criterion for integrated circuits given the growing importance of portable battery-operated devices. A typical…”
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Identification and Preliminary Characterization of Protein-Cysteine Farnesyltransferase by Manne, Veeraswamy, Roberts, Daniel, Tobin, Andrew, O'Rourke, Edward, De Virgilio, Marcia, Meyers, Chester, Ahmed, Nasheed, Kurz, Boris, Resh, Marilyn, Kung, Hsiang-Fu, Barbacid, Mariano

“…Ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (Cys-186 in mammalian Ras p21 proteins) in order to exert their…”
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Ha-ras Proteins Exhibit GTPase Activity: Point Mutations That Activate Ha-ras Gene Products Result in Decreased GTPase Activity by Manne, Veeraswamy, Bekesi, Eva, Kung, Hsiang-Fu

“…Several ras genes have been expressed at high levels in Escherichia coli and the resultant ras proteins were shown to be functional with respect to their…”
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A novel candidate for receptor-coupled phospholipase C purified from human platelets by Manne, V

“…The breakdown of polyphosphoinositides (PPI) but not phosphatidylinositol (PI) has been hypothesized as the primary event following agonist (hormones/growth…”
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Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart by Gomez, R, Goodman, L.E, Tripathy, S.K, O'Rourke, E, Manne, V, Tamanoi, F

“…Protein farnesyltransferase (FTase) catalyses the addition of a farnesyl group to a cysteine within the so-called 'CAAX box' at the C-terminus of various…”
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Identification of polyphosphoinositide-specific phospholipase C and its resolution from phosphoinositide-specific phospholipase C from human platelet extract by Manne, V

“…Sonicated platelet extract, obtained after high-speed centrifugation, was fractionated by phosphocellulose chromatography, and assayed for phosphodiesteric…”
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Characterization of phosphoinositide-specific phospholipase C from human platelets by Manne, V, Kung, H F

“…Phosphoinositide-specific phospholipase C (PI-PLC) from human platelet cytosol was purified 190-fold to a specific activity of 0.68 mumol of…”
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Guanosine Nucleotide Binding by Highly Purified Ha-ras-Encoded p21 Protein Produced in Escherichia coli by Manne, Veeraswamy, Yamazaki, Shigeko, Kung, Hsiang-Fu

“…High-level expression of the p21 protein product of the BALB murine sarcoma virus v-ras gene (similar to the product of the Harvey murine sarcoma virus…”
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Mechanism of Translational Control by Partial Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 by Siekierka, John, Manne, Veeraswamy, Ochoa, Severo

“…Catalysis of ternary complex formation by the GDP exchange factor (GEF), in the presence of Mg2+, is blocked by phosphorylation of the α subunit of the…”
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10'-Desmethoxystreptonigrin, a novel analog of streptonigrin by Liu, W C, Barbacid, M, Bulgar, M, Clark, J M, Crosswell, A R, Dean, L, Doyle, T W, Fernandes, P B, Huang, S, Manne, V

“…10'-Desmethoxystreptonigrin, a novel analog of streptonigrin produced by Streptomyces albus, was discovered in a screen for inhibitors of farnesylation of RAS…”
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A "fast track" to improve management of neovascular age related macular degeneration by Krivosic, V, Philippakis, E, Couturier, A, Dupas, B, Erginay, A, Desmettre, T, Streho, M, Bonnin, S, Mane, V, Jouvaud, S, Gualino, V, Durand, D, Tadayoni, R

“…To evaluate the role of a fast track for management of patients with neovascular age- related macular degeneration (nARMD) treated by intravitreal injection of…”
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Polypeptide Chain Initiation in Eukaryotes: Reversibility of the Ternary Complex-Forming Reaction by Siekierka, John, Manne, Veeraswamy, Mauser, Ljubica, Ochoa, Severo

“…In the last step of polypeptide chain initiation in eukaryotes, the interaction of the 40S preinitiation complex eIF-2· GTP· Met-tRNAi· 40S [the complex…”
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Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor by ROSE, William C, LEE, Francis Y. F, FAIRCHILD, Craig R, LYNCH, Mark, MONTICELLO, Thomas, KRAMER, Robert A, MANNER, Veeraswamy

“…BMS-214662 is a potent and selective inhibitor of farnesyltransferase (FTI). In rodent fibroblasts transformed by oncogenes, BMS-214662 reversed the…”
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Effects of Phospholipids and ADP-Ribosylation on GTP Hydrolysis by Escherichia coli-Synthesized Ha-ras-Encoded p21 by Tsai, Su-Chen, Adamik, Ronald, Moss, Joel, Vaughan, Martha, Manne, Veeraswamy, Kung, Hsiang-Fu

“…The Ha-ras protooncogene product p21, which may be involved in control of cellular growth, is a membrane protein that binds guanine nucleotides and hydrolyzes…”
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A bacteriophage T4 DNA packaging related DNA-dependent ATPase-endonuclease by Manne, V, Rao, V B, Black, L W

“…A new bacteriophage T4-induced DNA-dependent ATPase-endonuclease was purified to essential homogeneity from an extract of late infected Escherichia coli. Both…”
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Un « circuit court » pour améliorer la prise en charge des patients atteints de dégénérescence maculaire liée à l’âge néovasculaire by Krivosic, V., Philippakis, E., Couturier, A., Dupas, B., Erginay, A., Desmettre, T., Streho, M., Bonnin, S., Manne, V., Jouvaud, S., Gualino, V., Durand, D., Tadayoni, R.

“…Évaluer l’intérêt d’un « circuit court » pour la prise en charge des patients atteints de dégénérescence maculaire liée à l’âge néovasculaire (DMLAn). Les…”
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