Search Results - "MANN, L. L"

Innate Immunity and the Failing Heart: The Cytokine Hypothesis Revisited by Mann, Douglas L.

“…Elevated levels of inflammatory mediators have been identified in patients with heart failure, including heart failure with reduced and preserved ejection…”
Get full text

Reappraising the role of inflammation in heart failure by Adamo, Luigi, Rocha-Resende, Cibele, Prabhu, Sumanth D., Mann, Douglas L.

“…The observation that heart failure with reduced ejection fraction is associated with elevated circulating levels of pro-inflammatory cytokines opened a new…”
Get full text

Role of innate and adaptive immune mechanisms in cardiac injury and repair by Epelman, Slava, Liu, Peter P., Mann, Douglas L.

“…Key Points Cardiac injury can lead to cardiomyocyte death, intense inflammation, scar formation and, over time, adverse cardiac remodelling. Following injury,…”
Get full text

In search of new therapeutic targets and strategies for heart failure: recent advances in basic science by Shah, Ajay M, Prof, Mann, Douglas L, Prof

“…Summary Chronic heart failure continues to impose a substantial health-care burden, despite recent treatment advances. The key pathophysiological process that…”
Get full text

The head tracks and gaze predicts: how the world's best batters hit a ball by Mann, David L, Spratford, Wayne, Abernethy, Bruce

“…Hitters in fast ball-sports do not align their gaze with the ball throughout ball-flight; rather, they use predictive eye movement strategies that contribute…”
Get full text

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction by Pfeffer, Marc A, Claggett, Brian, Lewis, Eldrin F, Granger, Christopher B, Køber, Lars, Maggioni, Aldo P, Mann, Douglas L, McMurray, John J.V, Rouleau, Jean-Lucien, Solomon, Scott D, Steg, Philippe G, Berwanger, Otavio, Cikes, Maja, De Pasquale, Carmine G, East, Cara, Fernandez, Alberto, Jering, Karola, Landmesser, Ulf, Mehran, Roxana, Merkely, Béla, Vaghaiwalla Mody, Freny, Petrie, Mark C, Petrov, Ivo, Schou, Morten, Senni, Michele, Sim, David, van der Meer, Peter, Lefkowitz, Martin, Zhou, Yinong, Gong, Jianjian, Braunwald, Eugene

“…In a randomized trial, 5661 patients with acute myocardial infarction and a reduced left ventricular ejection fraction, pulmonary congestion, or both were…”
Get full text

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation by Epelman, Slava, Lavine, Kory J., Beaudin, Anna E., Sojka, Dorothy K., Carrero, Javier A., Calderon, Boris, Brija, Thaddeus, Gautier, Emmanuel L., Ivanov, Stoyan, Satpathy, Ansuman T., Schilling, Joel D., Schwendener, Reto, Sergin, Ismail, Razani, Babak, Forsberg, E. Camilla, Yokoyama, Wayne M., Unanue, Emil R., Colonna, Marco, Randolph, Gwendalyn J., Mann, Douglas L.

“…Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac…”
Get full text

Role of inflammatory cells in fibroblast activation by Hartupee, Justin, Mann, Douglas L

“…Abstract Although fibrosis is an essential response to acute cardiac tissue injury, prolonged myofibroblast activation and progressive fibrosis lead to further…”
Get full text

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response by Alasoo, Kaur, Rodrigues, Julia, Mukhopadhyay, Subhankar, Knights, Andrew J., Mann, Alice L., Kundu, Kousik, Hale, Christine, Dougan, Gordon, Gaffney, Daniel J.

“…Regulatory variants are often context specific, modulating gene expression in a subset of possible cellular states. Although these genetic effects can play…”
Get full text

The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure by Divakaran, Vijay, Mann, Douglas L

“…Recent studies have suggested a potentially important role for a family of tiny regulatory RNAs, known as microRNAs (miRNAs or miRs), in the control of diverse…”
Get full text

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart by Lavine, Kory J., Epelman, Slava, Uchida, Keita, Weber, Kassandra J., Nichols, Colin G., Schilling, Joel D., Ornitz, David M., Randolph, Gwendalyn J., Mann, Douglas L.

“…Significance This study addresses a fundamentally important and widely debated issue in the field of inflammation, which is why inflammation can be…”
Get full text

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation by Li, Wenjun, Feng, Guoshuai, Gauthier, Jason M, Lokshina, Inessa, Higashikubo, Ryuji, Evans, Sarah, Liu, Xinping, Hassan, Adil, Tanaka, Satona, Cicka, Markus, Hsiao, Hsi-Min, Ruiz-Perez, Daniel, Bredemeyer, Andrea, Gross, Richard W, Mann, Douglas L, Tyurina, Yulia Y, Gelman, Andrew E, Kagan, Valerian E, Linkermann, Andreas, Lavine, Kory J, Kreisel, Daniel

“…Non-apoptotic forms of cell death can trigger sterile inflammation through the release of danger-associated molecular patterns, which are recognized by innate…”
Get full text

Reconciling anthropogenic climate change with observed temperature 1998-2008 by Kaufmann, Robert K, Kauppi, Heikki, Mann, Michael L, Stock, James H

“…Given the widely noted increase in the warming effects of rising greenhouse gas concentrations, it has been unclear why global surface temperatures did not…”
Get full text

Incorporating Anthropogenic Influences into Fire Probability Models: Effects of Human Activity and Climate Change on Fire Activity in California by Mann, Michael L, Batllori, Enric, Moritz, Max A, Waller, Eric K, Berck, Peter, Flint, Alan L, Flint, Lorraine E, Dolfi, Emmalee

“…The costly interactions between humans and wildfires throughout California demonstrate the need to understand the relationships between them, especially in the…”
Get full text

Estimating acid soil effects on selected cereal crop productivities in Ethiopia: Comparing economic cost-effectiveness of lime and fertilizer applications by Warner, James M, Mann, Michael L, Chamberlin, Jordan, Tizale, Chilot Y

“…Acid soils are a major constraint to agricultural productivity in many parts of sub-Saharan Africa, including Ethiopia. Restoring soil pH to optimal ranges for…”
Get full text

Mechanisms and models in heart failure : A combinatorial approach by MANN, D. L

Get full text

Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial by Gold, Michael R., MD, PhD, Van Veldhuisen, Dirk J., MD, PhD, Hauptman, Paul J., MD, Borggrefe, Martin, MD, Kubo, Spencer H., MD, Lieberman, Randy A., MD, Milasinovic, Goran, MD, Berman, Brett J., MD, Djordjevic, Sanja, MD, Neelagaru, Suresh, MD, Schwartz, Peter J., MD, Starling, Randall C., MDs, MPH, Mann, Douglas L., MD

“…Abstract Background Heart Failure (HF) is increasing in prevalence and is a major cause of morbidity and mortality, despite advances in medical and device…”
Get full text

Predicting high-magnitude, low-frequency crop losses using machine learning: an application to cereal crops in Ethiopia by Mann, Michael L., Warner, James M., Malik, Arun S.

“…Timely and accurate agricultural impact assessments for droughts are critical for designing appropriate interventions and policy. These assessments are often…”
Get full text

Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future by Mann, Douglas L

“…ABSTRACT—Recent studies have identified the importance of proinflammatory mediators in the development and progression of heart failure. The growing…”
Get full text

Assessing the Physiologic Endotypes Responsible for REM- and NREM-Based OSA by Joosten, Simon A., Landry, Shane A., Wong, Ai-Ming, Mann, Dwayne L., Terrill, Philip I., Sands, Scott A., Turton, Anthony, Beatty, Caroline, Thomson, Luke, Hamilton, Garun S., Edwards, Bradley A.

“…Patients with OSA can have the majority of their respiratory events in rapid eye movement (REM) sleep or in non-rapid eye movement (NREM) sleep. No previous…”
Get full text