Search Results - "MANN, Giovanni E"

Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans by Keeley, Thomas P, Mann, Giovanni E

“…The extensive oxygen gradient between the air we breathe (Po ~21 kPa) and its ultimate distribution within mitochondria (as low as ~0.5-1 kPa) is testament to…”
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Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis by Ishii, Tetsuro, Warabi, Eiji, Mann, Giovanni E.

“…Astrocyte-neuron interactions protect neurons from iron-mediated toxicity. As dopamine can be metabolized to reactive quinones, dopaminergic neurons are…”
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology by Sies, Helmut, Belousov, Vsevolod V., Chandel, Navdeep S., Davies, Michael J., Jones, Dean P., Mann, Giovanni E., Murphy, Michael P., Yamamoto, Masayuki, Winterbourn, Christine

“…‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant molecules with vastly different properties and biological functions…”
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Short-chain fatty acids as modulators of redox signaling in health and disease by González-Bosch, Carmen, Boorman, Emily, Zunszain, Patricia A., Mann, Giovanni E.

“…Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated…”
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Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome by Patel, Bijal, Mann, Giovanni E., Chapple, Sarah J.

“…Diabetes and cardiometabolic disorders such as hypertension and obesity are major risk factors for the development of cardiovascular disease, with a wealth of…”
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Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic factor by Ishii, Tetsuro, Warabi, Eiji, Mann, Giovanni E.

“…Circadian clock genes regulate energy metabolism partly through neurotrophins in the body. The low affinity neurotrophin receptor p75NTR is a clock component…”
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Even free radicals should follow some rules: A Guide to free radical research terminology and methodology by Forman, Henry Jay, Augusto, Ohara, Brigelius-Flohe, Regina, Dennery, Phyllis A., Kalyanaraman, Balaraman, Ischiropoulos, Harry, Mann, Giovanni E., Radi, Rafael, Roberts, L. Jackson, Vina, Jose, Davies, Kelvin J.A.

“…Free radicals and oxidants are now implicated in physiological responses and in several diseases. Given the wide range of expertise of free radical…”
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Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment? by Nitti, Mariapaola, Furfaro, Anna Lisa, Mann, Giovanni E

“…Among antioxidants in the human body, bilirubin has been recognized over the past 20 years to afford protection against different chronic conditions, including…”
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Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple, Sarah J., Siow, Richard C.M., Mann, Giovanni E.

“…Excessive reactive oxygen species (ROS) generation is as a major cause of oxidative stress and is implicated in cellular dysfunction in aging, cardiovascular…”
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Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance by Ishii, Tetsuro, Mann, Giovanni E

“…Culturing cells and tissues in vitro has provided valuable insights into the molecular mechanisms regulating redox signaling in cells with implications for…”
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Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood–brain barrier disruption and neurological deficits in stroke by Alfieri, Alessio, Srivastava, Salil, Siow, Richard C.M, Cash, Diana, Modo, Michel, Duchen, Michael R, Fraser, Paul A, Williams, Steven C.R, Mann, Giovanni E

“…Disruption of the blood–brain barrier (BBB) and cerebral edema are the major pathogenic mechanisms leading to neurological dysfunction and death after ischemic…”
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Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary cilia by Ishii, Tetsuro, Warabi, Eiji, Mann, Giovanni E.

“…Endothelial cells are sensitive to mechanical stress and respond differently to oscillatory flow versus unidirectional flow. This review highlights the…”
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Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway by Cheng, Xinghua, Siow, Richard C M, Mann, Giovanni E

“…Type 2 diabetes is an age-related disease associated with vascular pathologies, including severe blindness, renal failure, atherosclerosis, and stroke…”
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Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease by Chapple, Sarah J, Cheng, Xinghua, Mann, Giovanni E

“…4-hydroxynonenal (HNE) is a lipid hydroperoxide end product formed from the oxidation of n-6 polyunsaturated fatty acids. The relative abundance of HNE within…”
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Reactive oxygen species are crucial “pro-life “survival signals in plants by Van Breusegem, Frank, H. Foyer, Christine, E. Mann, Giovanni

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Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation by Warpsinski, Gabriela, Smith, Matthew J., Srivastava, Salil, Keeley, Thomas P., Siow, Richard C.M., Fraser, Paul A., Mann, Giovanni E.

“…Ischemic stroke is associated with a surge in reactive oxygen species generation during reperfusion. The narrow therapeutic window for the delivery of…”
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Gestational Diabetes Mellitus Impairs Nrf2-Mediated Adaptive Antioxidant Defenses and Redox Signaling in Fetal Endothelial Cells In Utero by XINGHUA CHENG, CHAPPIE, Sarah J, PATEL, Bijal, PUSZYK, William, SUGDEN, David, XIAOKE YIN, MAYR, Manuel, SIOW, Richard C. M, MANN, Giovanni E

“…In utero exposure to gestational diabetes mellitus (GDM) is associated with an increased risk of type 2 diabetes and cardiovascular disease in later life, yet…”
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Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo by Brewer, Alison C., Murray, Thomas V.A., Arno, Matthew, Zhang, Min, Anilkumar, Narayana P., Mann, Giovanni E., Shah, Ajay M.

“…NADPH oxidase-4 (Nox4) is an important modulator of redox signaling that is inducible at the level of transcriptional expression in multiple cell types. By…”
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Dietary isoflavones and vascular protection: Activation of cellular antioxidant defenses by SERMs or hormesis? by Siow, Richard C.M., Mann, Giovanni E.

“…During the past decade nutrigenomic studies in humans, animal models and cultured cells have provided important and novel insights into the mechanisms by which…”
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Introduction to Special Issue on ‘Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine by Mann, Giovanni E., Forman, Henry J.

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