Search Results - "MANN, David M. A"

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau by Taniguchi-Watanabe, Sayuri, Arai, Tetsuaki, Kametani, Fuyuki, Nonaka, Takashi, Masuda-Suzukake, Masami, Tarutani, Airi, Murayama, Shigeo, Saito, Yuko, Arima, Kunimasa, Yoshida, Mari, Akiyama, Haruhiko, Robinson, Andrew, Mann, David M. A., Iwatsubo, Takeshi, Hasegawa, Masato

“…Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset of neurodegenerative diseases. We have analyzed…”
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Magnetite pollution nanoparticles in the human brain by Maher, Barbara A., Ahmed, Imad A. M., Karloukovski, Vassil, MacLaren, Donald A., Foulds, Penelope G., Allsop, David, Mann, David M. A., Torres-Jardón, Ricardo, Calderon-Garciduenas, Lilian

“…Biologically formed nanoparticles of the strongly magnetic mineral, magnetite, were first detected in the human brain over 20 y ago [Kirschvink JL,…”
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A harmonized classification system for FTLD-TDP pathology by Mackenzie, Ian R. A., Neumann, Manuela, Baborie, Atik, Sampathu, Deepak M., Du Plessis, Daniel, Jaros, Evelyn, Perry, Robert H., Trojanowski, John Q., Mann, David M. A., Lee, Virginia M. Y.

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The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships by Snowden, Julie S., Thompson, Jennifer C., Stopford, Cheryl L., Richardson, Anna M. T., Gerhard, Alex, Neary, David, Mann, David M. A.

“…Accuracy of clinical diagnosis of dementia is increasingly important for therapeutic and scientific investigations. In this study, we examine diagnostic…”
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The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome by Davidson, Yvonne S, Robinson, Andrew, Prasher, Vee P, Mann, David M A

“…While post mortem studies have identified the major cell types and functional systems affected in Alzheimer's disease (AD) the initial sites and molecular…”
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Classification and pathology of primary progressive aphasia by Harris, Jennifer M, Gall, Claire, Thompson, Jennifer C, Richardson, Anna M.T, Neary, David, du Plessis, Daniel, Pal, Piyali, Mann, David M.A, Snowden, Julie S, Jones, Matthew

“…OBJECTIVE:We aimed to determine the extent to which patients with progressive language impairment conform to 2011 primary progressive aphasia (PPA)…”
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Molecular analysis and biochemical classification of TDP-43 proteinopathy by TSUJI, Hiroshi, ARAI, Tetsuaki, SAITO, Yuko, MURAYAMA, Shigeo, AKIYAMA, Haruhiko, HASEGAWA, Masato, MANN, David M. A, TAMAOKA, Akira, KAMETANI, Fuyuki, NONAKA, Takashi, YAMASHITA, Makiko, SUZUKAKE, Masami, HOSOKAWA, Masato, YOSHIDA, Mari, HATSUTA, Hiroyuki, TAKAO, Masaki

“…Amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa pathology are progressive neurodegenerative diseases…”
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Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects by Halliday, Glenda, Bigio, Eileen H., Cairns, Nigel J., Neumann, Manuela, Mackenzie, Ian R. A., Mann, David M. A.

“…Frontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically heterogeneous. Three major proteins are implicated in its pathogenesis…”
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Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update by Mackenzie, Ian R. A., Neumann, Manuela, Bigio, Eileen H., Cairns, Nigel J., Alafuzoff, Irina, Kril, Jillian, Kovacs, Gabor G., Ghetti, Bernardino, Halliday, Glenda, Holm, Ida E., Ince, Paul G., Kamphorst, Wouter, Revesz, Tamas, Rozemuller, Annemieke J. M., Kumar-Singh, Samir, Akiyama, Haruhiko, Baborie, Atik, Spina, Salvatore, Dickson, Dennis W., Trojanowski, John Q., Mann, David M. A.

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Alzheimer's disease diagnosis by blood plasma molecular fluorescence spectroscopy (EEM) by dos Santos, Ricardo Fernandes, Paraskevaidi, Maria, Mann, David M. A., Allsop, David, Santos, Marfran C. D., Morais, Camilo L. M., Lima, Kássio M. G.

“…Despite tremendous research advances in detecting Alzheimer's disease (AD), traditional diagnostic tests remain expensive, time-consuming or invasive. The…”
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Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy by Yokota, Osamu, Davidson, Yvonne, Bigio, Eileen H., Ishizu, Hideki, Terada, Seishi, Arai, Tetsuaki, Hasegawa, Masato, Akiyama, Haruhiko, Sikkink, Stephen, Pickering-Brown, Stuart, Mann, David M. A.

“…TDP-43 is characteristically accumulated in TDP-43 proteinopathies such as frontotemporal lobar degeneration and motor neurone disease, but is also present in…”
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Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis by Kasai, Takashi, Tokuda, Takahiko, Ishigami, Noriko, Sasayama, Hiroshi, Foulds, Penelope, Mitchell, Douglas J., Mann, David M. A., Allsop, David, Nakagawa, Masanori

“…There is mounting pathological, biochemical and genetic evidence that the metabolism and aggregation of the 43-kDa transactive response (TAR)-DNA-binding…”
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TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer’s disease and frontotemporal lobar degeneration by Foulds, Penelope, McAuley, Erica, Gibbons, Linda, Davidson, Yvonne, Pickering-Brown, Stuart M., Neary, David, Snowden, Julie S., Allsop, David, Mann, David M. A.

“…Autopsy studies have shown that about 55% of patients with frontotemporal lobar degeneration (FTLD) and 25% of patients with Alzheimer’s disease (AD) harbour…”
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Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies by Paleologou, Katerina E., Kragh, Christine L., Mann, David M. A., Salem, Sultan A., Al-Shami, Rania, Allsop, David, Hassan, Ahmed H., Jensen, Poul H., El-Agnaf, Omar M. A.

“…A number of neurodegenerative diseases including Parkinson's disease, dementia with Lewy bodies (DLB) and multiple system atrophy are characterized by the…”
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Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations by Mackenzie, Ian R. A., Neumann, Manuela, Bigio, Eileen H., Cairns, Nigel J., Alafuzoff, Irina, Kril, Jillian, Kovacs, Gabor G., Ghetti, Bernardino, Halliday, Glenda, Holm, Ida E., Ince, Paul G., Kamphorst, Wouter, Revesz, Tamas, Rozemuller, Annemieke J. M., Kumar-Singh, Samir, Akiyama, Haruhiko, Baborie, Atik, Spina, Salvatore, Dickson, Dennis W., Trojanowski, John Q., Mann, David M. A.

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Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK by Robinson, Andrew C., Palmer, Laura, Love, Seth, Hamard, Marie, Esiri, Margaret, Ansorge, Olaf, Lett, Debbie, Attems, Johannes, Morris, Chris, Troakes, Claire, Selvackadunco, Sashika, King, Andrew, Al-Sarraj, Safa, Mann, David M. A.

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TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype by Davidson, Yvonne S., Raby, Samantha, Foulds, Penelope G., Robinson, Andrew, Thompson, Jennifer C., Sikkink, Stephen, Yusuf, Imran, Amin, Hanan, DuPlessis, Daniel, Troakes, Claire, Al-Sarraj, Safa, Sloan, Carolyn, Esiri, Margaret M., Prasher, Vee P., Allsop, David, Neary, David, Pickering-Brown, Stuart M., Snowden, Julie S., Mann, David M. A.

“…TDP-43 immunoreactive (TDP-43-ir) pathological changes were investigated in the temporal cortex and hippocampus of 11 patients with autosomal dominant familial…”
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Prion-like spreading of pathological α-synuclein in brain by MASUDA-SUZUKAKE, Masami, NONAKA, Takashi, HOSOKAWA, Masato, OIKAWA, Takayuki, ARAI, Tetsuaki, AKIYAMA, Haruhiko, MANN, David M. A, HASEGAWA, Masato

“…α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of neurodegenerative α-synucleinopathies. However, the…”
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Influence of APOE genotype in primary age-related tauopathy by Robinson, Andrew C, Davidson, Yvonne S, Roncaroli, Federico, Minshull, James, Tinkler, Phillip, Horan, Michael A, Payton, Antony, Pendleton, Neil, Mann, David M A

“…The term "Primary age-related tauopathy" (PART) was coined in 2014 to describe the common neuropathological observation of neurofibrillary tangles without…”
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Structure-based classification of tauopathies by Shi, Yang, Zhang, Wenjuan, Yang, Yang, Murzin, Alexey G., Falcon, Benjamin, Kotecha, Abhay, van Beers, Mike, Tarutani, Airi, Kametani, Fuyuki, Garringer, Holly J., Vidal, Ruben, Hallinan, Grace I., Lashley, Tammaryn, Saito, Yuko, Murayama, Shigeo, Yoshida, Mari, Tanaka, Hidetomo, Kakita, Akiyoshi, Ikeuchi, Takeshi, Robinson, Andrew C., Mann, David M. A., Kovacs, Gabor G., Revesz, Tamas, Ghetti, Bernardino, Hasegawa, Masato, Goedert, Michel, Scheres, Sjors H. W.

“…The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported…”
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