Search Results - "MANJUNATHA, R"

Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases by Kini, R. Manjunatha, Koh, Cho Yeow

“…[Display omitted] Cardiovascular diseases such as coronary and peripheral artery diseases, venous thrombosis, stroke, hypertension, and heart failure are…”
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Structure, function and evolution of three-finger toxins: Mini proteins with multiple targets by Kini, R. Manjunatha, Doley, Robin

“…Snake venoms are complex mixtures of pharmacologically active peptides and proteins. These protein toxins belong to a small number of superfamilies of…”
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Toxins for decoding interface selectivity in nicotinic acetylcholine receptors by Kini, R Manjunatha

“…Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that play crucial roles in neurotransmission and regulate complex processes…”
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Accelerated evolution of toxin genes: Exonization and intronization in snake venom disintegrin/metalloprotease genes by Kini, R. Manjunatha

“…Toxin genes in animals undergo accelerated evolution compared to non-toxin genes to be effective and competitive in prey capture, as well as to enhance their…”
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Anticoagulant proteins from snake venoms: structure, function and mechanism by Kini, R Manjunatha

“…Over the last several decades, research on snake venom toxins has provided not only new tools to decipher molecular details of various physiological processes,…”
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Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes by Kini, R Manjunatha

“…Venom phospholipase A2 (PLA2) enzymes share similarity in structure and catalytic function with mammalian enzymes. However, in contrast to mammalian enzymes,…”
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Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites by Kini, R Manjunatha, Koh, Cho Yeow

“…Snake venom metalloproteases, in addition to their contribution to the digestion of the prey, affect various physiological functions by cleaving specific…”
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Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms by Kini, R. Manjunatha, Utkin, Yuri N.

“…In many animals belonging to different taxa, venoms evolved as a means of defense and/or a means of attack/hunting [...]…”
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High resolution proteomics of Aedes aegypti salivary glands infected with either dengue, Zika or chikungunya viruses identify new virus specific and broad antiviral factors by Chowdhury, Avisha, Modahl, Cassandra M., Missé, Dorothée, Kini, R. Manjunatha, Pompon, Julien

“…Arboviruses such as dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses infect close to half a billion people per year, and are primarily transmitted…”
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Exactin: A specific inhibitor of Factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus by Girish, Vallerinteavide Mavelli, Kini, R. Manjunatha

“…Unwanted clots lead to heart attack and stroke that result in a large number of deaths. Currently available anticoagulants have some drawbacks including their…”
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Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolution by Aoki-Shioi, Narumi, Jobichen, Chacko, Sivaraman, J, Kini, R Manjunatha

“…Snake venoms are complex mixtures of enzymes and nonenzymatic proteins that have evolved to immobilize and kill prey animals or deter predators. Among them,…”
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Unveiling the potential role of natriuretic peptide receptor a isoforms in fine-tuning the cGMP production and tissue-specific function by Ang, Wei Fong, Liao, Dan, Koh, Cho Yeow, Kini, R. Manjunatha

“…Atrial natriuretic peptide (ANP) is a peptide hormone that regulates blood pressure and volume. ANP interacts with natriuretic peptide receptor-A (NPR-A) to…”
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Purification of Intramineral Peptides from Cuttlebones and In Vitro Activity in CaCO 3 Biomineralization by Mahadevan, Gomathi, Brahma, Rajeev Kungur, Kini, R Manjunatha, Valiyaveettil, Suresh

“…Living organisms develop functional hard structures such as teeth, bones, and shells from calcium salts through mineralization for managing vital functions to…”
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Purification of Intramineral Peptides from Cuttlebones and In Vitro Activity in CaCO3 Biomineralization by Mahadevan, Gomathi, Brahma, Rajeev Kungur, Kini, R. Manjunatha, Valiyaveettil, Suresh

“…Living organisms develop functional hard structures such as teeth, bones, and shells from calcium salts through mineralization for managing vital functions to…”
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Tail wags the dog: activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner by Sridharan, Sindhuja, Kini, R Manjunatha

“…Natriuretic peptides (NPs) are potent vasoactive hormones, which maintain pressure-volume homoeostasis. Snake venom NPs exhibit distinct biological activity…”
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Niemann-Pick Type C2 Proteins in Aedes aegypti : Molecular Modelling and Prediction of Their Structure-Function Relationships by Thambi, Prathigna Jaishankar, Modahl, Cassandra M, Kini, R Manjunatha

“…is a major vector that transmits arboviruses through the saliva injected into the host. Salivary proteins help in uninterrupted blood intake and enhance the…”
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Repurposed drug to the rescue of snakebite victims by Koh, Cho Yeow, Bendre, Rohan, Kini, R Manjunatha

“…Preclinical data suggest the possibility of repurposing a drug for early intervention in envenoming by snake venom rich in metalloproteinases (Albulescu , this…”
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JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands by Chowdhury, Avisha, Modahl, Cassandra M, Tan, Siok Thing, Wong Wei Xiang, Benjamin, Missé, Dorothée, Vial, Thomas, Kini, R. Manjunatha, Pompon, Julien Francis, Dimopoulos, George, Cherry, Sara

“…Arbovirus infection of Aedes aegypti salivary glands (SGs) determines transmission. However, there is a dearth of knowledge on SG immunity. Here, we…”
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Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis by Fong, Siew-Wai, Kini, R Manjunatha, Ng, Lisa F P

“…Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the…”
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Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims by Kini, R Manjunatha, Sidhu, Sachdev S, Laustsen, Andreas Hougaard

“…Snakebite envenoming is a neglected tropical disease that each year claims the lives of 80,000⁻140,000 victims worldwide. The only effective treatment against…”
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