Search Results - "MANICKAM, N."

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups by Parfitt, David A., Lane, Amelia, Ramsden, Conor M., Carr, Amanda-Jayne F., Munro, Peter M., Jovanovic, Katarina, Schwarz, Nele, Kanuga, Naheed, Muthiah, Manickam N., Hull, Sarah, Gallo, Jean-Marc, da Cruz, Lyndon, Moore, Anthony T., Hardcastle, Alison J., Coffey, Peter J., Cheetham, Michael E.

“…Leber congenital amaurosis (LCA) is an inherited retinal dystrophy that causes childhood blindness. Photoreceptors are especially sensitive to an intronic…”
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Biodegradation and dissolution of polyaromatic hydrocarbons by Stenotrophomonas sp by Tiwari, Bhagyashree, Manickam, N., Kumari, Smita, Tiwari, Akhilesh

“…•Stenotrophomonas sp. strain IITR87 degraded polycyclic aromatic hydrocarbons.•Degradation occurred in order for phenanthrene, followed by pyrene and…”
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Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells by Schwarz, Nele, Carr, Amanda-Jayne, Lane, Amelia, Moeller, Fabian, Chen, Li Li, Aguilà, Mònica, Nommiste, Britta, Muthiah, Manickam N, Kanuga, Naheed, Wolfrum, Uwe, Nagel-Wolfrum, Kerstin, da Cruz, Lyndon, Coffey, Peter J, Cheetham, Michael E, Hardcastle, Alison J

“…Mutations in the RP2 gene lead to a severe form of X-linked retinitis pigmentosa. RP2 patients frequently present with nonsense mutations and no treatments are…”
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Decreased Sestrin levels in patients with type 2 diabetes and dyslipidemia and their association with the severity of atherogenic index by Sundararajan, S., Jayachandran, I., Subramanian, S. C., Anjana, R. M., Balasubramanyam, M., Mohan, V., Venkatesan, B., Manickam, N.

“…Purpose We earlier reported that Sestrin2 regulates monocyte activation and atherogenic events through AMPK-mTOR nexus under high-glucose and dyslipidemic…”
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Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs by Ramsden, Conor M., Nommiste, Britta, R. Lane, Amelia, Carr, Amanda-Jayne F., Powner, Michael B., J. K. Smart, Matthew, Chen, Li Li, Muthiah, Manickam N., Webster, Andrew R., Moore, Anthony T., Cheetham, Michael E., da Cruz, Lyndon, Coffey, Peter J.

“…Inherited retinal dystrophies are an important cause of blindness, for which currently there are no effective treatments. In order to study this heterogeneous…”
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Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images by Linderman, Rachel E, Muthiah, Manickam N, Omoba, Sarah B, Litts, Katie, Tarima, Sergey, Visotcky, Alexis, Kim, Judy E, Carroll, Joseph

“…To characterize sources of inter- and intrasubject variability in quantitative foveal avascular zone (FAZ) metrics. Two 3×3-mm optical coherence tomography…”
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Area-level poverty, race/ethnicity & dialysis star ratings by Kshirsagar, Abhijit V, Manickam, Raj N, Mu, Yi, Flythe, Jennifer E, Chin, Andrew I, Bang, Heejung

“…The Centers for Medicare and Medicaid Services recently released a five star rating system as part of 'Dialysis Facility Compare' to help patients identify and…”
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Area-Level Poverty and Excess Hospital Readmission Ratios by Manickam, Raj N., MS, Mu, Yi, MS, Kshirsagar, Abhijit V., MD, MPH, Bang, Heejung, PhD

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Characterization of the novel HCH-degrading strain, Microbacterium sp. ITRC1 by MANICKAM, N, MAU, M, SCHLÖMANN, M

“…A gram-positive Microbacterium sp. strain, ITRC1, that was able to degrade the persistent and toxic hexachlorocyclohexane (HCH) isomers was isolated and…”
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Metabolic profiles and phylogenetic diversity of microbial communities from chlorinated pesticides contaminated sites of different geographical habitats of India by Manickam, N, Pathak, A, Saini, H.S, Mayilraj, S, Shanker, R

“…To study the microbial communities in three sites contaminated with chlorinated pesticides and evaluation of dehydrodechlorinase (linA) gene variants involved…”
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novel pathway for the biodegradation of γ-hexachlorocyclohexane by a Xanthomonas sp. strain ICH12 by Manickam, N, Misra, R, Mayilraj, S

“…To isolate γ-hexachlorocyclohexane (HCH)-degrading bacteria from contaminated soil and characterize the metabolites formed and the genes involved in the…”
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Vicinal thiols are required for activation of the αIIbβ3 platelet integrin by MANICKAM, N., AHMAD, S. S., ESSEX, D. W.

“…Background: Closely spaced thiols in proteins that interconvert between the dithiol form and disulfide bonds are called vicinal thiols. These thiols provide a…”
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Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC) by Carter, David A., Smart, Matthew J. K., Letton, William V. G., Ramsden, Conor M., Nommiste, Britta, Chen, Li Li, Fynes, Kate, Muthiah, Manickam N., Goh, Pollyanna, Lane, Amelia, Powner, Michael B., Webster, Andrew R., da Cruz, Lyndon, Moore, Anthony T., Coffey, Peter J., Carr, Amanda-Jayne F.

“…Autosomal dominant vitreoretinochoroidopathy (ADVIRC) is a rare, early-onset retinal dystrophy characterised by distinct bands of circumferential pigmentary…”
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Isolation and characterization of a Pseudomonas sp. strain IITR01 capable of degrading α‐endosulfan and endosulfan sulfate by Bajaj, A, Pathak, A, Mudiam, M.R, Mayilraj, S, Manickam, N

“…Aim: To isolate bacteria capable of degrading endosulfan (ES) and the more toxic ES sulfate and to characterize their metabolites. Methods and Results: A…”
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Isolation of hexachlorocyclohexane-degrading Sphingomonas sp. by dehalogenase assay and characterization of genes involved in γ-HCH degradation by Manickam, N, Reddy, M.K, Saini, H.S, Shanker, R

“…To screen and identify bacteria from contaminated soil samples which can degrade hexachlorocyclohexane (HCH)-isomers based on dechlorinase enzyme activity and…”
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The Presentation, Pace, and Profile of Infection and Sepsis Patients Hospitalized Through the Emergency Department: An Exploratory Analysis by Liu, Vincent X, Bhimarao, Meghana, Greene, John D, Manickam, Raj N, Martinez, Adriana, Schuler, Alejandro, Barreda, Fernando, Escobar, Gabriel J

“…To characterize the signs and symptoms of sepsis, compare them with those from simple infection and other emergent conditions and evaluate their association…”
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Rethinking Thirty-Day Hospital Readmissions: Shorter Intervals Might Be Better Indicators Of Quality Of Care by Chin, David L, Bang, Heejung, Manickam, Raj N, Romano, Patrick S

“…Public reporting and payment programs in the United States have embraced thirty-day readmissions as an indicator of between-hospital variation in the quality…”
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Homology modeling and docking studies of Comamonas testosteroni B-356 biphenyl-2,3-dioxygenase involved in degradation of polychlorinated biphenyls by Baig, M.S., Manickam, N.

“…Biphenyl dioxygenase is a microbial enzyme which catalyzes the stereospecific dioxygenation of aromatic rings of biphenyl congeners leading to their…”
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Quantifying the breadth of antibiotic exposure in sepsis and suspected infection using spectrum scores by Smith, Joshua T., Manickam, Raj N., Barreda, Fernando, Greene, John D., Bhimarao, Meghana, Pogue, Jason, Jones, Makoto, Myers, Laura, Prescott, Hallie C., Liu, Vincent X.

“…A retrospective cohort study. Studies to quantify the breadth of antibiotic exposure across populations remain limited. Therefore, we applied a validated…”
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Effects of dietary supplementation of fish and vegetable oils on the growth performance and muscle compositions of the freshwater prawn Macrobrachium rosenbergii by Muralisankar, T., Bhavan, P. Saravana, Radhakrishnan, S., Seenivasan, C., Manickam, N., Shanthi, R.

“…The present investigation was conducted to assess the suitability of three vegetable oils (sunflower oil, coconut oil and castor oil) as an alternative dietary…”
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