Search Results - "MANHART, Susanne"

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides by Schlenzig, Dagmar, Manhart, Susanne, Cinar, Yeliz, Kleinschmidt, Martin, Hause, Gerd, Willbold, Dieter, Funke, Susanne Aileen, Schilling, Stephan, Demuth, Hans-Ulrich

“…N-Terminally truncated and pyroglutamate (pGlu) modified amyloid β (Aβ) peptides are major constituents of amyloid deposits in sporadic and inherited…”
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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor by Parthier, Christoph, Kleinschmidt, Martin, Neumann, Piotr, Rudolph, Rainer, Manhart, Susanne, Schlenzig, Dagmar, Fanghänel, Jörg, Rahfeld, Jens-Ulrich, Demuth, Hans-Ulrich, Stubbs, Milton T

“…Incretins, endogenous polypeptide hormones released in response to food intake, potentiate insulin secretion from pancreatic β cells after oral glucose…”
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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions by Schilling, Stephan, Hoffmann, Torsten, Manhart, Susanne, Hoffmann, Matthias, Demuth, Hans-Ulrich

“…N-terminal pyroglutamate (pGlu) formation from glutaminyl precursors is a posttranslational event in the processing of bioactive neuropeptides such as…”
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Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat by Piteau, Shalea, Olver, Amy, Kim, Su-Jin, Winter, Kyle, Pospisilik, John Andrew, Lynn, Francis, Manhart, Susanne, Demuth, Hans-Ulrich, Speck, Madeleine, Pederson, Raymond A., McIntosh, Christopher H.S.

“…In type 2 diabetes (T2DM) β-cell responsiveness to glucose-dependent insulinotropic polypeptide (GIP) is reduced. In a model of T2DM, the VDF Zucker rat, GIP…”
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Dipeptidyl Peptidase IV-Resistant [d-Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats by HINKE, Simon A, GELLING, Richard W, PEDERSON, Raymond A, MANHART, Susanne, CUILAN NIAN, DEMUTH, Hans-Ulrich, MCINTOSH, Christopher H. S

“…Dipeptidyl Peptidase IV-Resistant [ d -Ala 2 ]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats…”
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On the Seeding and Oligomerization of pGlu-Amyloid Peptides (in vitro) by Schilling, Stephan, Lauber, Thomas, Schaupp, Michael, Manhart, Susanne, Scheel, Eike, Böhm, Gerald, Demuth, Hans-Ulrich

“…Oligomerization of amyloid β (Aβ) peptides is the decisive event in the development of Alzheimer's disease (AD), the most common neurogenerative disorder in…”
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Pharmacokinetics of ferric bepectate—a new intravenous iron drug for treating iron deficiency by Muñoz, Manuel, Olsen, Peter Skov, Petersen, Tonny Studsgaard, Manhart, Susanne, Waldorff, Stig

“…IV iron is indicated in clinical conditions, where rapid anaemia alleviation and repletion of iron stores are required. The acute toxicity of IV iron is…”
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[Ser2]- and [Ser(P)2]Incretin Analogs by Hinke, Simon A., Manhart, Susanne, Kühn-Wache, Kerstin, Nian, Cuilan, Demuth, Hans-Ulrich, Pederson, Raymond A., McIntosh, Christopher H.S.

“…Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP; also known as gastric inhibitory polypeptide) are incretin hormones that…”
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Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP) by Hinke, Simon A, Manhart, Susanne, Pamir, Nathalie, Demuth, Hans-Ulrich, W. Gelling, Richard, Pederson, Raymond A, McIntosh, Christopher H.S

“…The incretins are a class of hormones released from the small bowel that act on the endocrine pancreas to potentiate insulin secretion in a glucose-dependent…”
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Glutaminyl Cyclases Display Significant Catalytic Proficiency for Glutamyl Substrates by Seifert, Franziska, Schulz, Katrin, Koch, Birgit, Manhart, Susanne, Demuth, Hans-Ulrich, Schilling, Stephan

“…N-Terminal glutaminyl and glutamyl residues of peptides and proteins tend to form pyroglutamic acid (pGlu) by intramolecular cylization. The rate constants for…”
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Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY‐cleaving peptidases and potential drug interactions in CNS and Periphery by Wagner, Leona, Wolf, Raik, Zeitschel, Ulrike, Rossner, Steffen, Petersén, Åsa, Leavitt, Blair R., Kästner, Florian, Rothermundt, Matthias, Gärtner, Ulf‐Torsten, Gündel, Daniel, Schlenzig, Dagmar, Frerker, Nadine, Schade, Jutta, Manhart, Susanne, Rahfeld, Jens‐Ulrich, Demuth, Hans‐Ulrich, Hörsten, Stephan

“…The bioactivity of neuropeptide Y (NPY) is either N‐terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)‐like enzymes or…”
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Inhibition of glutaminyl cyclase targeting Alzheimer's disease by Demuth, Hans, Schilling, Stephan, Holger, Cynis, Manhart, Susanne, Glund, Konrad

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O2‐12‐05: Inhibition of glutaminyl cyclase targeting Alzheimer's disease by Demuth, Hans, Schilling, Stephan, Holger, Cynis, Manhart, Susanne, Glund, Konrad

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Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases by Böhme, Livia, Hoffmann, Torsten, Manhart, Susanne, Wolf, Raik, Demuth, Hans-Ulrich

“…Neuritic plaques of Alzheimer patients are composed of multiple protein components. Among them, the amyloid beta-peptides (Abeta) 1-40/42 and further N- and…”
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Rigidity and Flexibility of Dipeptidyl Peptidase IV: Crystal Structures of and Docking Experiments with DPIV by Engel, Michael, Hoffmann, Torsten, Manhart, Susanne, Heiser, Ulrich, Chambre, Sylvie, Huber, Robert, Demuth, Hans-Ulrich, Bode, Wolfram

“…Dipeptidyl peptidase IV (DPIV) is an α,β-hydrolase-like serine exopeptidase, which removes dipeptides, preferentially with a C-terminal l-Pro residue, from the…”
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Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation by Wagner, Leona, Kaestner, Florian, Wolf, Raik, Stiller, Harald, Heiser, Ulrich, Manhart, Susanne, Hoffmann, Torsten, Rahfeld, Jens-Ulrich, Hans-Ulrich, Demuth, Rothermundt, Matthias, von Hörsten, Stephan

“…Abstract Background Dipeptidyl peptidase 4 (DPP4; EC 3.4.14.5; CD26) is a membrane-bound or shedded serine protease that hydrolyzes dipeptides from the…”
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Isoaspartate residues dramatically influence substrate recognition and turnover by proteases by Böhme, Livia, Bär, Joachim Wolfgang, Hoffmann, Torsten, Manhart, Susanne, Ludwig, Hans-Henning, Rosche, Fred, Demuth, Hans-Ulrich

“…Posttranslational modifications influence the structure, stability and biological activity of proteins. Most of the reactions are enzyme-catalyzed, but some,…”
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A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects by Lues, Inge, Weber, Frank, Meyer, Antje, Bühring, Uli, Hoffmann, Torsten, Kühn-Wache, Kerstin, Manhart, Susanne, Heiser, Ulrich, Pokorny, Rolf, Chiesa, Joseph, Glund, Konrad

“…Abstract Introduction Pyroglutamate-amyloid-β (pE-Aβ) peptides are major components of Aβ-oligomers and Aβ-plaques, which are regarded as key culprits of…”
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Does human attractin have DP4 activity? by Friedrich, Daniel, Hoffmann, Torsten, Bär, Joachim, Wermann, Michael, Manhart, Susanne, Heiser, Ulrich, Demuth, Hans-Ulrich

“…Mutations in the mouse ATRN gene, which encodes attractin, offer links between this protein and pigmentation, metabolism, immune status and neurodegeneration…”
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Heterologous Expression and Characterization of Human Glutaminyl Cyclase:  Evidence for a Disulfide Bond with Importance for Catalytic Activity by Schilling, Stephan, Hoffmann, Torsten, Rosche, Fred, Manhart, Susanne, Wasternack, Claus, Demuth, Hans-Ulrich

“…Glutaminyl cyclase (QC, EC 2.3.2.5) catalyzes the formation of pyroglutamate residues from glutamine at the N-terminus of peptides and proteins. In the current…”
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