Search Results - "MANGUS, Katharina"

Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons by Grabrucker, Andreas M., Boeckers, Tobias M., Mangus, Katharina, Hagmeyer, Simone

“…Various recent studies revealed that biometal dyshomeostasis plays a crucial role in the pathogenesis of neurological disorders such as autism spectrum…”
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Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo by Chhabra, Resham, Ruozi, Barbara, Vilella, Antonietta, Belletti, Daniela, Mangus, Katharina, Pfaender, Stefanie, Sarowar, Tasnuva, Boeckers, Tobias Maria, Zoli, Michele, Forni, Flavio, Vandelli, Maria Angela, Tosi, Giovanni, Grabrucker, Andreas Martin

“…A dyshomeostasis of zinc ions has been reported for many psychiatric and neurodegenerative disorders including schizophrenia, attention deficit hyperactivity…”
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Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders by GRABRUCKER, Stefanie, JANNETTI, Linda, KREUTZ, Michael R, EHRET, Günter, BOECKERS, Tobias M, GRABRUCKER, Andreas M, ECKERT, Matti, GAUB, Simone, CHHABRA, Resham, PFAENDER, Stefanie, MANGUS, Katharina, PARAMESHWAR PASHAM REDDY, RANKOVIC, Vladan, SCHMEISSER, Michael J

“…Proteins of the ProSAP/Shank family act as major organizing scaffolding elements within the postsynaptic density of excitatory synapses. Deletions, mutations…”
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Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3 by Pfaender, Stefanie, Sauer, Ann Katrin, Hagmeyer, Simone, Mangus, Katharina, Linta, Leonhard, Liebau, Stefan, Bockmann, Juergen, Huguet, Guillaume, Bourgeron, Thomas, Boeckers, Tobias M., Grabrucker, Andreas M.

“…Phelan McDermid Syndrome (PMDS) is a genetic disorder characterized by features of Autism spectrum disorders. Similar to reports of Zn deficiency in autistic…”
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The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation by Grabrucker, Stefanie, Proepper, Christian, Mangus, Katharina, Eckert, Matti, Chhabra, Resham, Schmeisser, Michael J., Boeckers, Tobias M., Grabrucker, Andreas M.

“…Recently, mutations in ProSAP2/Shank3 have been discovered as one of the genetic factors for schizophrenia (SCZ). Here, we show that the postsynaptic density…”
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Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses by Baecker, Tanja, Mangus, Katharina, Pfaender, Stefanie, Chhabra, Resham, Boeckers, Tobias M., Grabrucker, Andreas M.

“…Recent studies suggest that synaptic pathology in autism spectrum disorder (ASD) might be caused by the disruption of a signaling pathway at excitatory…”
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Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2 by Sarowar, Tasnuva, Grabrucker, Stefanie, Föhr, Karl, Mangus, Katharina, Eckert, Matti, Bockmann, Juergen, Boeckers, Tobias M, Grabrucker, Andreas M

“…The majority of neurons within the central nervous system receive their excitatory inputs via small, actin-rich protrusions called dendritic spines. Spines can…”
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