Search Results - "MANDLEKAR, S"

Prodrug design to improve pharmacokinetic and drug delivery properties: challenges to the discovery scientists by Jana, S, Mandlekar, S, Marathe, P

“…The prodrug design is a versatile, powerful method that can be applied to a wide range of parent drug molecules, administration routes, and formulations…”
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Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro by Zhang, Yueping, Han, Yong-Hae, Putluru, Siva Prasad, Matta, Murali Krishna, Kole, Prashant, Mandlekar, Sandhya, Furlong, Michael T, Liu, Tongtong, Iyer, Ramaswamy A, Marathe, Punit, Yang, Zheng, Lai, Yurong, Rodrigues, A David

“…Although the metabolism and disposition of diclofenac (DF) has been studied extensively, information regarding the plasma levels of its acyl-β-d-glucuronide…”
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Mechanisms of tamoxifen-induced apoptosis by Mandlekar, S, Kong, A N

“…Tamoxifen (TAM) has been used in the treatment of breast cancer for over a decade. The observed clinical efficacy of TAM has been attributed to both growth…”
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546-P: Video Call-Based Assessment of Physical Fitness through Diabefly Digital Therapeutics Program for People with T2D in India by BHAGAT, MADHURA, MANDLEKAR, ANURADHA S., VERMA, RITIKA, KULKARNI, SAMPADA S., SELVAN, CHITRA, MODI, ALOK D., SHENOY, MOHAN T., JAIN, ALPESH L., DAS, RABINDRA, GUNTUR, SAIMALA

“…Background: Exercise is an integral aspect for effective diabetes management. Supervised home-based exercise through exercise prescriptions customized based on…”
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Development of an in vivo rat screen model to predict pharmacokinetic interactions of CYP3A4 substrates by Mandlekar, S. V., Rose, A. V., Cornelius, G., Sleczka, B., Caporuscio, C., Wang, J., Marathe, P. H.

“…With the advent of polytherapy, drug interactions have become a common clinical problem. Although in vitro data are routinely used for the prediction of drug…”
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Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites : Activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines by MANDLEKAR, Sandhya, HEBBAR, Vidya, CHRISTOV, Konstantin, KONG, A-N. Tony

“…The antiestrogen tamoxifen (TAM) is extensively metabolized by cytochrome P-450 in humans and rodents. The active, estrogen receptor-binding metabolites,…”
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Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition by Lai, Yurong, Mandlekar, Sandhya, Shen, Hong, Holenarsipur, Vinay K, Langish, Robert, Rajanna, Prabhakar, Murugesan, Senthilkumar, Gaud, Nilesh, Selvam, Sabariya, Date, Onkar, Cheng, Yaofeng, Shipkova, Petia, Dai, Jun, Humphreys, William G, Marathe, Punit

“…In the present study, an open-label, three-treatment, three-period clinical study of rosuvastatin (RSV) and rifampicin (RIF) when administered alone and in…”
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Effect of supplementation of Manno-Oligosaccharide and b-glucans on maize based meal on commercial broilers by Shendare, R C, Gongle, M A, Rajput, A B, Wanjari, B V, Mandlekar, S M

“…A study with 200 vencobb broilers was carried out to compare the effect of the use of Manno-Oligosaccharide & b-glucans of Saccharomyces cerevisiae cell wall…”
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459MO Phase Ia study to evaluate GDC-6036 monotherapy in patients with solid tumors with a KRAS G12C mutation by Patel, M., Lee, J-S., De Miguel, M.J., Burns, T., Falcon Gonzalez, A., Kim, T.W., Krebs, M.G., Prenen, H., Shacham Shmueli, E., Desai, J., Lorusso, P., Sacher, A., Choi, Y., Dharia, N., Lin, M.T., Mandlekar, S., Royer-Joo, S., Schutzman, J.L., Garralda, E.

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A novel raft-forming antacid suspension using a natural dietary fibre by Mandlekar, Sandhya V., Marathe, Suneeta S., Devarajan, Padma V.

“…The formulation and in vitro evaluation of a raft-forming antacid suspension using a natural dietary fibre, isapgol (Plantago ovata) husk, along with sodium…”
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Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells by MANDLEKAR, Sandhya, RONG YU, TAN, Tse-Hua, KONG, Ah-Ng Tony

“…Tamoxifen (TAM) is widely used in the treatment of breast cancer. The cytostatic effects of TAM have been attributed to the antagonism of estrogen receptor…”
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Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals by Yu, Rong, Lei, Wei, Mandlekar, Sandhya, Weber, Michael J., Der, Channing J., Wu, Jie, Kong, A.-N. Tony

“…Mitogen-activated protein kinase (MAPK) cascades are activated by diverse extracellular signals and participate in the regulation of an array of cellular…”
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Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE) by Kong, A.-N. Tony, Owuor, Edward, Yu, Rong, Hebbar, Vidya, Chen, Chi, Hu, Rong, Mandlekar, Sandhya

“…Cellular responses to xenobiotic-induced stress can signal proliferation, differentiation, homeostasis, apoptosis, or necrosis. To better understand the…”
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Signal transduction events elicited by cancer prevention compounds by Kong, A N, Yu, R, Hebbar, V, Chen, C, Owuor, E, Hu, R, Ee, R, Mandlekar, S

“…Many chemopreventive agents have been shown to modulate gene expression including induction of phase II detoxifying enzymes, such as glutathione S-transferases…”
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p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens by Yu, Rong, Mandlekar, Sandhya, Lei, Wei, Fahl, William E., Tan, Tse-Hua, Kong, A.-N.Tony

“…Phase II drug-metabolizing enzymes, such as glutathione S-transferase and quinone reductase, play an important role in the detoxification of chemical…”
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Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis by Kong, A N, Yu, R, Chen, C, Mandlekar, S, Primiano, T

“…Many natural products elicit diverse pharmacological effects. Using two classes of potential chemopreventive compounds, the phenolic compounds and the…”
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Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways by Yu, R, Hebbar, V, Kim, D W, Mandlekar, S, Pezzuto, J M, Kong, A N

“…Resveratrol, a phenolic compound found in grapes and other food products, prevents chemical-induced carcinogenesis in a number of animal models of cancers. To…”
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Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity by YU, R, MANDLEKAR, S, HARVEY, K. J, UCKER, D. S, KONG, A.-N. T

“…Isothiocyanates exert strong anticarcinogenic effects in a number of animal models of cancer, presumably by modulation of xenobiotic-metabolizing enzymes, such…”
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Molecular mechanisms of butylated hydroxylanisole-induced toxicity: induction of apoptosis through direct release of cytochrome c by Yu, R, Mandlekar, S, Kong, A N

“…Butylated hydroxyanisole (BHA), a commonly used food preservative, is reported to have anticarcinogenic properties in some animal models. However, the use of…”
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Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells by RONG YU, MANDLEKAR, S, RUBEN, S, JIAN NI, KONG, A.-N. T

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce cell death in a variety of transformed cells but spared the normal…”
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