Search Results - "MANDERFIELD, Lauren J"

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung by Jain, Rajan, Barkauskas, Christina E., Takeda, Norifumi, Bowie, Emily J., Aghajanian, Haig, Wang, Qiaohong, Padmanabhan, Arun, Manderfield, Lauren J., Gupta, Mudit, Li, Deqiang, Li, Li, Trivedi, Chinmay M., Hogan, Brigid L. M., Epstein, Jonathan A.

“…The plasticity of differentiated cells in adult tissues undergoing repair is an area of intense research. Pulmonary alveolar type II cells produce surfactant…”
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Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest by Manderfield, Lauren J, Aghajanian, Haig, Engleka, Kurt A, Lim, Lillian Y, Liu, Feiyan, Jain, Rajan, Li, Li, Olson, Eric N, Epstein, Jonathan A

“…Notch signaling has well-defined roles in the assembly of arterial walls and in the development of the endothelium and smooth muscle of the vasculature. Hippo…”
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Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts by Jain, Rajan, Li, Deqiang, Gupta, Mudit, Manderfield, Lauren J., Ifkovits, Jamie L., Wang, Qiaohong, Liu, Feiyan, Liu, Ying, Poleshko, Andrey, Padmanabhan, Arun, Raum, Jeffrey C., Li, Li, Morrisey, Edward E., Lu, Min Min, Won, Kyoung-Jae, Epstein, Jonathan A.

“…Making cardiomyocytes In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle…”
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Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development by Singh, Anamika, Ramesh, Sindhu, Cibi, Dasan Mary, Yun, Lim Sze, Li, Jun, Li, Li, Manderfield, Lauren J., Olson, Eric N., Epstein, Jonathan A., Singh, Manvendra K.

“…Formation of the coronary vasculature is a complex and precisely coordinated morphogenetic process that begins with the formation of epicardium. The epicardium…”
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Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall by MANDERFIELD, Lauren J, HIGH, Frances A, ENGLEKA, Kurt A, FEIYAN LIU, LI LI, RENTSCHLER, Stacey, EPSTEIN, Jonathan A

“…Notch signaling in vascular smooth muscle precursors is required for smooth muscle differentiation. Jagged1 expression on endothelium activates Notch in…”
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Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor by Aghajanian, Haig, Cho, Young Kuk, Manderfield, Lauren J., Herling, Madison R., Gupta, Mudit, Ho, Vivienne C., Li, Li, Degenhardt, Karl, Aharonov, Alla, Tzahor, Eldad, Epstein, Jonathan A.

“…Organogenesis and regeneration require coordination of cellular proliferation, regulated in part by secreted growth factors and cognate receptors, with tissue…”
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Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype by RENTSCHLER, Stacey, YEN, Alberta H, JIA LU, PETRENKO, Nataliya B, MIN MIN LU, MANDERFIELD, Lauren J, PATEL, Vickas V, FISHMAN, Glenn I, EPSTEIN, Jonathan A

“…Notch signaling has previously been shown to play an essential role in regulating cell fate decisions and differentiation during cardiogenesis in many systems…”
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Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest by Manderfield, Lauren J, Engleka, Kurt A, Aghajanian, Haig, Gupta, Mudit, Yang, Steven, Li, Li, Baggs, Julie E, Hogenesch, John B, Olson, Eric N, Epstein, Jonathan A

“…Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic…”
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Hopx distinguishes hippocampal from lateral ventricle neural stem cells by Li, Deqiang, Takeda, Norifumi, Jain, Rajan, Manderfield, Lauren J., Liu, Feiyan, Li, Li, Anderson, Stewart A., Epstein, Jonathan A.

“…In the adult dentate gyrus (DG) and in the proliferative zone lining the lateral ventricle (LV-PZ), radial glia-like (RGL) cells are neural stem cells (NSCs)…”
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Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest by Manderfield, Lauren J., Engleka, Kurt A., Aghajanian, Haig, Gupta, Mudit, Yang, Steven, Li, Li, Baggs, Julie E., Hogenesch, John B., Olson, Eric N., Epstein, Jonathan A.

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Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction by Ramjee, Vimal, Li, Deqiang, Manderfield, Lauren J, Liu, Feiyan, Engleka, Kurt A, Aghajanian, Haig, Rodell, Christopher B, Lu, Wen, Ho, Vivienne, Wang, Tao, Li, Li, Singh, Anamika, Cibi, Dasan M, Burdick, Jason A, Singh, Manvendra K, Jain, Rajan, Epstein, Jonathan A

“…Ischemic heart disease resulting from myocardial infarction (MI) is the most prevalent form of heart disease in the United States. Post-MI cardiac remodeling…”
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Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction by Poleshko, Andrey, Shah, Parisha P., Gupta, Mudit, Babu, Apoorva, Morley, Michael P., Manderfield, Lauren J., Ifkovits, Jamie L., Calderon, Damelys, Aghajanian, Haig, Sierra-Pagán, Javier E., Sun, Zheng, Wang, Qiaohong, Li, Li, Dubois, Nicole C., Morrisey, Edward E., Lazar, Mitchell A., Smith, Cheryl L., Epstein, Jonathan A., Jain, Rajan

“…Progenitor cells differentiate into specialized cell types through coordinated expression of lineage-specific genes and modification of complex chromatin…”
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KCNE4 domains required for inhibition of KCNQ1 by Manderfield, Lauren J., Daniels, Melissa A., Vanoye, Carlos G., George Jr, Alfred L.

“…Voltage-gated potassium (K v ) channels are modulated in distinct ways by members of the KCNE family of single transmembrane domain accessory subunits. KCNE4…”
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Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits by Vanoye, Carlos G, Welch, Richard C, Daniels, Melissa A, Manderfield, Lauren J, Tapper, Andrew R, Sanders, Charles R, George, Jr, Alfred L

“…Modulation of voltage-gated potassium (KV) channels by the KCNE family of single transmembrane proteins has physiological and pathophysiological importance…”
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Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves by Jain, Rajan, Engleka, Kurt A, Rentschler, Stacey L, Manderfield, Lauren J, Li, Li, Yuan, Lijun, Epstein, Jonathan A

“…Congenital anomalies of the aortic valve are common and are associated with progressive valvular insufficiency and/or stenosis. In addition, aneurysm,…”
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Endocardial Hippo signaling regulates myocardial growth and cardiogenesis by Artap, Stanley, Manderfield, Lauren J., Smith, Cheryl L., Poleshko, Andrey, Aghajanian, Haig, See, Kelvin, Li, Li, Jain, Rajan, Epstein, Jonathan A.

“…The Hippo signaling pathway has been implicated in control of cell and organ size, proliferation, and endothelial-mesenchymal transformation. This pathway…”
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Islet1 Derivatives in the Heart Are of Both Neural Crest and Second Heart Field Origin by Engleka, Kurt A, Manderfield, Lauren J, Brust, Rachael D, Li, Li, Cohen, Ashley, Dymecki, Susan M, Epstein, Jonathan A

“…RATIONALE:Islet1 (Isl1) has been proposed as a marker of cardiac progenitor cells derived from the second heart field and is utilized to identify and purify…”
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KCNE4 can co-associate with the IKs (KCNQ1-KCNE1) channel complex by Manderfield, Lauren J, George, Alfred L. Jr

“…Voltage-gated potassium (KV) channels can form heteromultimeric complexes with a variety of accessory subunits, including KCNE proteins. Heterologous…”
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KCNE4 can co‐associate with the I Ks (KCNQ1–KCNE1) channel complex by Manderfield, Lauren J., George, Alfred L.

“…Voltage‐gated potassium (K V ) channels can form heteromultimeric complexes with a variety of accessory subunits, including KCNE proteins. Heterologous…”
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Abstract 13073: Epicardial YAP/TAZ Regulate an Immune Suppressive Response Following Myocardial Infarction by Ramjee, Vimal, Singh, Manvendra K, Liu, Feiyan, Engleka, Kurt A, Manderfield, Lauren J, Olson, Eric N, Epstein, Jonathan A

“…Ischemic heart disease constitutes the most prevalent type of heart disease in the US. Remodeling post-myocardial infarction (MI) is a multifaceted process…”
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