Search Results - "MANDELL, B"

Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2 by Gabai-Kapara, Efrat, Lahad, Amnon, Kaufman, Bella, Friedman, Eitan, Segev, Shlomo, Renbaum, Paul, Beeri, Rachel, Gal, Moran, Grinshpun-Cohen, Julia, Djemal, Karen, Mandell, Jessica B., Lee, Ming K., Beller, Uziel, Catane, Raphael, King, Mary-Claire, Levy-Lahad, Ephrat

“…In the Ashkenazi Jewish (AJ) population of Israel, 11% of breast cancer and 40% of ovarian cancer are due to three inherited founder mutations in the cancer…”
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Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing by Walsh, Tom, Lee, Ming K., Casadei, Silvia, Thornton, Anne M., Stray, Sunday M., Pennil, Christopher, Nord, Alex S., Mandell, Jessica B., Swisher, Elizabeth M., King, Mary-Claire

“…Inherited loss-of-function mutations in the tumor suppressor genes BRCA1, BRCA2, and multiple other genes predispose to high risks of breast and/or ovarian…”
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The Toxin-Antitoxin MazEF Drives Staphylococcus aureus Biofilm Formation, Antibiotic Tolerance, and Chronic Infection by Ma, Dongzhu, Mandell, Jonathan B, Donegan, Niles P, Cheung, Ambrose L, Ma, Wanyan, Rothenberger, Scott, Shanks, Robert M Q, Richardson, Anthony R, Urish, Kenneth L

“…is the major organism responsible for surgical implant infections. Antimicrobial treatment of these infections often fails, leading to expensive surgical…”
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Contribution of Inherited Mutations in the BRCA2-Interacting Protein PALB2 to Familial Breast Cancer by CASADEI, Silvia, NORQUIST, Barbara M, WALSH, Tom, STRAY, Sunday, MANDELL, Jessica B, LEE, Ming K, STAMATOYANNOPOULOS, John A, KING, Mary-Claire

“…Inherited mutations in the BRCA2-interacting protein PALB2 are known to be associated with increased risks of developing breast cancer. To evaluate the…”
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Dose optimization in surgical prophylaxis: sub-inhibitory dosing of vancomycin increases rates of biofilm formation and the rates of surgical site infection by Brothers, Kimberly M., Parker, Dana M., Taguchi, Masashi, Ma, Dongzhu, Mandell, Jonathan B., Thurlow, Lance L., Byrapogu, Venkata C., Urish, Kenneth L.

“…Antibiotic stewardship is viewed as having great public health benefit with limited direct benefit to the patient at the time of administration. The objective…”
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Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 by King, Mary-Claire, Marks, Joan H., Mandell, Jessica B., The New York Breast Cancer Study Group

“…Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We…”
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Methicillin resistant Staphylococcus aureus mazEF expression promotes infections by influencing cellular growth, antibiotic sensitivity, and formation of biofilms by Mandell, Jonathan B., Gish, Charles, Cappellini, Alex J., Parker, Dana M., Brothers, Kimberly M., Ma, Dongzhu, Urish, Kenneth L.

“…Staphylococcus aureus infections are hard to treat due to the emergence of antibiotic resistant strains, as well as their ability to form biofilms. The MazEF…”
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Elimination of Antibiotic Resistant Surgical Implant Biofilms Using an Engineered Cationic Amphipathic Peptide WLBU2 by Mandell, Jonathan B., Deslouches, Berthony, Montelaro, Ronald C., Shanks, Robert M. Q., Doi, Yohei, Urish, Kenneth L.

“…Antibiotics are unable to remove biofilms from surgical implants. This high antibiotic tolerance is related to bacterial persisters, a sub-population of…”
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Engineered peptide PLG0206 overcomes limitations of a challenging antimicrobial drug class by Huang, David B, Brothers, Kimberly M, Mandell, Jonathan B, Taguchi, Masashi, Alexander, Peter G, Parker, Dana M, Shinabarger, Dean, Pillar, Chris, Morrissey, Ian, Hawser, Stephen, Ghahramani, Parviz, Dobbins, Despina, Pachuda, Nicholas, Montelaro, Ronald, Steckbeck, Jonathan D, Urish, Kenneth L

“…The absence of novel antibiotics for drug-resistant and biofilm-associated infections is a global public health crisis. Antimicrobial peptides explored to…”
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Human Monoclonal Antibodies Directed against Toxins A and B Prevent Clostridium difficile-Induced Mortality in Hamsters by Babcock, Gregory J, Broering, Teresa J, Hernandez, Hector J, Mandell, Robert B, Donahue, Katherine, Boatright, Naomi, Stack, Anne M, Lowy, Israel, Graziano, Robert, Molrine, Deborah, Ambrosino, Donna M, Thomas, William D. Jr

“…Clostridium difficile is the leading cause of nosocomial antibiotic-associated diarrhea, and recent outbreaks of strains with increased virulence underscore…”
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Staphylococcus epidermidis Biofilms Have a High Tolerance to Antibiotics in Periprosthetic Joint Infection by Koch, John A, Pust, Taylor M, Cappellini, Alex J, Mandell, Jonathan B, Ma, Dongzhu, Shah, Neel B, Brothers, Kimberly M, Urish, Kenneth L

“…Both and are commonly associated with periprosthetic joint infections (PJIs). The treatment of PJI can be challenging because biofilms are assumed to have an…”
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The Efficacy of Topical Cefiderocol Treatment of Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis Is Dependent upon the State of the Corneal Epithelium by Romanowski, Eric G, Mandell, Jonathan B, Jhanji, Vishal, Shanks, Robert M Q

“…An overlooked factor in the efficacy of topical antibiotics to treat bacterial keratitis is the state of the corneal epithelium. Recently, we evaluated topical…”
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ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper by Mandell, Jonathan B., Douglas, Nerone, Ukani, Vrutika, Beumer, Jan H., Guo, Jianxia, Payne, John, Newman, Rebecca, Mancinelli, Luigi, Intini, Giuseppe, Anderson, Carolyn J., Watters, Rebecca, Weiss, Kurt

“…Aldehyde dehydrogenase 1A1 (ALDH) is a cancer stem cell marker highly expressed in metastatic cells. Disulfiram (Dis) is an FDA-approved antialcoholism drug…”
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Association of a single nucleotide polymorphism in the calpastatin gene with carcass and meat quality traits of beef cattle by Schenkel, F. S, Miller, S. P, Jiang, Z, Mandell, I. B, Ye, X, Li, H, Wilton, J. W

“…Calpastatin (CAST) is a naturally occurring protein that inhibits the normal tenderization of meat as it ages postmortem. A SNP was identified in the CAST gene…”
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Results of the Avonex Combination Trial (ACT) in relapsing-remitting MS by COHEN, J. A, IMREY, P. B, HUTTON, G. J, MANDELL, B. F, SCOTT, T. F, ZHANG, H, APPERSON-HANSEN, C, BECK, G. J, HOUGHTALING, P. L, KARAFA, M. T, STADTLER, M, CALABRESI, P. A, EDWARDS, K. R, EICKENHORST, T, FELTON, W. L, FISHER, E, FOX, R. J, GOODMAN, A. D, HARA-CLEAVER, C

“…To assess the safety, tolerability, and efficacy of interferon beta-1a (IFNbeta-1a) combined with methotrexate (MTX), i.v. methylprednisolone (IVMP), or both…”
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Antioxidant 1 copper chaperone gene expression and copper levels in dog osteosarcoma patients by Rivera, Pedro L., Li, William T., Bhogal, Sumail, Mandell, Jonathan B., Belayneh, Rebekah, Hankins, Margaret L., Payne, John T., Watters, Rebecca J., Weiss, Kurt R.

“…Twenty‐four dogs with OS underwent limb amputation. Serum, OS tumour, and normal bone were harvested at time of surgery. RNA was extracted and gene expression…”
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The Staphylococcus aureus toxin–antitoxin system YefM–YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation by Qi, Xinyu, Brothers, Kimberly M, Ma, Dongzhu, Mandell, Jonathan B, Donegan, Niles P, Cheung, Ambrose L, Richardson, Anthony R, Urish, Kenneth L

“…The high antibiotic tolerance of Staphylococcus aureus biofilms is associated with challenges for treating periprosthetic joint infection. The toxin–antitoxin…”
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Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: In Vitro Support for a Novel Drug Repurposing Strategy by Weiss, Kurt R., Guo, Jianxia, Beumer, Jan H., Fisch, Matthew, Lu, Feiqi, Mandell, Jonathan B., Watters, Rebecca J.

“…Although many cancer cells have significantly higher copper concentrations compared with normal cells and tissues, the role of copper in cancer biology and…”
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Prospective Activity of PLG0206, an Engineered Antimicrobial Peptide, on Chronic Periprosthetic Joint Infection Total Knee Arthroplasty Components Ex Vivo : The Knee Explant Analysis (KnEA) Study by Huang, David, Parker, Dana, Mandell, Jonathan B, Brothers, Kimberly M, Gish, Charles G, Koch, John A, Pachuda, Nicholas, Dobbins, Despina, Steckbeck, Jonathan, Urish, Kenneth L

“…PLG0206 is an engineered antimicrobial peptide that has completed phase 1 clinical studies. A prospective study was completed on explanted implants from…”
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Disparity of dietary effects on collagen characteristics and toughness between two beef muscles by Archile-Contreras, A.C., Mandell, I.B., Purslow, P.P.

“…Manipulation of growth rate and/or diet has been shown to affect protein turnover and may be used to improve beef quality. This trial was conducted to evaluate…”
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