Search Results - "MANCZAK, Maria"

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease by Manczak, Maria, Kandimalla, Ramesh, Yin, Xiangling, Reddy, P Hemachandra

“…Abstract The purpose of our study was to determine the toxic effects of hippocampal mutant APP and amyloid beta (Aβ) in 12-month-old APP transgenic mice. Using…”
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Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease by Kandimalla, Ramesh, Manczak, Maria, Yin, Xiangling, Wang, Rui, Reddy, P Hemachandra

“…Abstract The purpose of our study was to understand the toxic effects of hippocampal phosphorylated tau in tau mice. Using rotarod and Morris water maze (MWM)…”
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Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity by Manczak, Maria, Kandimalla, Ramesh, Yin, Xiangling, Reddy, P Hemachandra

“…Abstract The purpose of our study was to better understand the effects of mitochondrial-division inhibitor 1 (Mdivi-1) on mitochondrial fission, mitochondrial…”
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Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease by Reddy, P Hemachandra, Yin, XiangLing, Manczak, Maria, Kumar, Subodh, Pradeepkiran, Jangampalli Adi, Vijayan, Murali, Reddy, Arubala P

“…Abstract The purpose of our study was to determine the toxic effects of hippocampal mutant APP (mAPP) and amyloid beta (Aβ) in human mAPP complementary DNA…”
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Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease by Kandimalla, Ramesh, Manczak, Maria, Fry, David, Suneetha, Yeguvapalli, Sesaki, Hiromi, Reddy, P Hemachandra

“…The purpose of our study was to understand the protective effects of a partial reduction of dynamin-related protein 1 (Drp1) in Alzheimer’s disease (AD)…”
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Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics by Reddy, P. Hemachandra, Tripathi, Raghav, Troung, Quang, Tirumala, Karuna, Reddy, Tejaswini P., Anekonda, Vishwanath, Shirendeb, Ulziibat P., Calkins, Marcus J., Reddy, Arubala P., Mao, Peizhong, Manczak, Maria

“…Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's disease (AD) progression. Loss of synapses and synaptic damage are the…”
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Reduced VDAC1 protects against Alzheimer's disease, mitochondria, and synaptic deficiencies by Manczak, Maria, Sheiko, Tatiana, Craigen, William J, Reddy, P Hemachandra

“…The objective of this study was to elucidate the effect of VDAC1 on Alzheimer's disease (AD)-related genes, mitochondrial activity, and synaptic viability…”
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Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases by Reddy, P. Hemachandra, Reddy, Tejaswini P, Manczak, Maria, Calkins, Marcus J, Shirendeb, Ulziibat, Mao, Peizhong

“…Abstract The purpose of this article is to review the recent developments of abnormal mitochondrial dynamics, mitochondrial fragmentation, and neuronal damage…”
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Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer's Disease by Calkins, Marcus J, Manczak, Maria, Reddy, P Hemachandra

“…In neuronal systems, the health and activity of mitochondria and synapses are tightly coupled. For this reason, it has been postulated that mitochondrial…”
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Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction by Reddy, P Hemachandra, Mani, Geethalakshmi, Park, Byung S, Jacques, Joline, Murdoch, Geoffrey, Whetsell, Jr, William, Kaye, Jeffrey, Manczak, Maria

“…The objective of our research was to determine synaptic protein levels in brain specimens from AD subjects and age-matched control subjects. Further, to…”
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Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease by Reddy, P. Hemachandra, McWeeney, Shannon, Park, Byung S., Manczak, Maria, Gutala, Ramana V., Partovi, Dara, Jung, Youngsin, Yau, Vincent, Searles, Robert, Mori, Motomi, Quinn, Joseph

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the impairment of cognitive functions and by beta amyloid (Aβ) plaques in…”
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Time‐course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging by Manczak, Maria, Jung, Youngsin, Park, Byung S., Partovi, Dara, Reddy, P. Hemachandra

“…The study of aging is critical for a better understanding of many age‐related diseases. The free radical theory of aging, one of the prominent aging…”
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Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease by Manczak, Maria, Mao, Peizhong, Nakamura, Kazuhiro, Bebbington, Christopher, Park, Byung, Reddy, P. Hemachandra

“…The purpose of our study was to investigate microglia and astrocytes that are associated with human mutant amyloid precursor protein and amyloid beta (Aβ). We…”
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Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts by Chung, Eunhee, Joiner, Hayli E., Skelton, Tracer, Looten, Kalli D., Manczak, Maria, Reddy, P. Hemachandra

“…Maternal exercise during pregnancy has been shown to improve the long‐term health of offspring in later life. Mitochondria are important organelles for…”
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Mitochondrial structural and functional dynamics in Huntington's disease by Reddy, P. Hemachandra, Mao, Peizhong, Manczak, Maria

“…Abstract Huntington's disease (HD) is an autosomal, dominantly inherited neurodegenerative disorder, characterized by chorea, involuntary movements, and…”
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Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's Disease and multiple sclerosis by Hemachandra Reddy, P, Manczak, Maria, Zhao, Wei, Nakamura, Kazuhiro, Bebbington, Christopher, Yarranton, Geoffrey, Mao, Peizhong

“…The objective of our study was to determine granulocyte-macrophage colony-stimulating factor (GM-CSF) activity in the brain following GM-CSF induction. We…”
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Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease by Yin, Xiangling, Manczak, Maria, Reddy, P Hemachandra

“…The objective of this study was to determine the protective effects of the mitochondria-targeted molecules MitoQ and SS31 in striatal neurons that stably…”
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Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer's Disease by Reddy, P Hemachandra, Manczak, Maria, Yin, XiangLing

“…The purpose our study was to determine the protective effects of mitochondria division inhibitor 1 (Mdivi1) in Alzheimer's disease (AD). Mdivi1 is hypothesized…”
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Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease by MANCZAK, Maria, HEMACHANDRA REDDY, P

“…The purpose of our study was to determine the relationship between voltage-dependent anion channel 1 protein (VDAC1) and amyloid beta (Aβ) and phosphorylated…”
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Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage by MANCZAK, Maria, CALKINS, Marcus J, HEMACHANDRA REDDY, P

“…The purpose of our study was to better understand the relationship between mitochondrial structural proteins, particularly dynamin-related protein 1 (Drp1) and…”
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