Search Results - "MANCUSO, J"

Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies by Wei, Spencer C., Anang, Nana-Ama A. S., Sharma, Roshan, Andrews, Miles C., Reuben, Alexandre, Levine, Jacob H., Cogdill, Alexandria P., Mancuso, James J., Wargo, Jennifer A., Pe’er, Dana, Allison, James P.

“…Immune checkpoint blockade therapy targets T cell-negative costimulatory molecules such as cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell…”
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Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes by Cannon, Christopher P, Pratley, Richard, Dagogo-Jack, Samuel, Mancuso, James, Huyck, Susan, Masiukiewicz, Urszula, Charbonnel, Bernard, Frederich, Robert, Gallo, Silvina, Cosentino, Francesco, Shih, Weichung J, Gantz, Ira, Terra, Steven G, Cherney, David Z.I, McGuire, Darren K

“…In this randomized trial, patients with type 2 diabetes and atherosclerotic cardiovascular disease received 5 mg or 15 mg of ertugliflozin or placebo once…”
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A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention by Wei, Spencer C, Meijers, Wouter C, Axelrod, Margaret L, Anang, Nana-Ama A S, Screever, Elles M, Wescott, Elizabeth C, Johnson, Douglas B, Whitley, Elizabeth, Lehmann, Lorenz, Courand, Pierre-Yves, Mancuso, James J, Himmel, Lauren E, Lebrun-Vignes, Benedicte, Wleklinski, Matthew J, Knollmann, Bjorn C, Srinivasan, Jayashree, Li, Yu, Atolagbe, Oluwatomisin T, Rao, Xiayu, Zhao, Yang, Wang, Jing, Ehrlich, Lauren I R, Sharma, Padmanee, Salem, Joe-Elie, Balko, Justin M, Moslehi, Javid J, Allison, James P

“…Immune checkpoint inhibitors (ICI) targeting CTLA4 or PD-1/PD-L1 have transformed cancer therapy but are associated with immune-related adverse events,…”
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Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242 by Ranganathan, M, DeMartinis, N, Huguenel, B, Gaudreault, F, Bednar, M M, Shaffer, C L, Gupta, S, Cahill, J, Sherif, M A, Mancuso, J, Zumpano, L, D’Souza, D C

“…There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N -methyl- d -aspartate…”
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Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities by Jenkins, Christopher M, Mancuso, David J, Yan, Wei, Sims, Harold F, Gibson, Beverly, Gross, Richard W

“…Genetic knockout of hormone-sensitive lipase in mice has implicated the presence of other intracellular triacylglycerol (TAG) lipases mediating TAG hydrolysis…”
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Methods of dendritic spine detection: From Golgi to high-resolution optical imaging by Mancuso, J.J, Chen, Y, Li, X, Xue, Z, Wong, S.T.C

“…Highlights ► Golgi staining and manual spine identification have provided insight into neurodegeneration. ► Advances in microscopy and tissue labeling have…”
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Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome[S] by Kiebish, Michael A., Yang, Kui, Liu, Xinping, Mancuso, David J., Guan, Shaoping, Zhao, Zhongdan, Sims, Harold F., Cerqua, Rebekah, Cade, W. Todd, Han, Xianlin, Gross, Richard W.

“…Barth syndrome is a complex metabolic disorder caused by mutations in the mitochondrial transacylase tafazzin. Recently, an inducible tafazzin shRNA knockdown…”
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Macrophages and intravascular OCT bright spots: a quantitative study by Phipps, Jennifer E, Vela, Deborah, Hoyt, Taylor, Halaney, David L, Mancuso, J Jacob, Buja, L Maximilian, Asmis, Reto, Milner, Thomas E, Feldman, Marc D

“…This study hypothesized that bright spots in intravascular optical coherence tomography (IVOCT) images may originate by colocalization of plaque materials of…”
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STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs by Garcia-Alvarez, Gisela, Lu, Bo, Yap, Kenrick An Fu, Wong, Loo Chin, Thevathasan, Jervis Vermal, Lim, Lynette, Ji, Fang, Tan, Kia Wee, Mancuso, James J, Tang, Willcyn, Poon, Shou Yu, Augustine, George J, Fivaz, Marc

“…STIMs (STIM1 and STIM2 in mammals) are transmembrane proteins that reside in the endoplasmic reticulum (ER) and regulate store-operated Ca(2+) entry (SOCE)…”
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Walking in nature may improve affect but not cognition by Trammell, Janet P, Harriger, Jennifer A, Krumrei-Mancuso, Elizabeth J

“…Beneficial effects of natural environments on affect have been consistently reported, but effects on cognition have been less consistent. We examined affect…”
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Course of avoidant/restrictive food intake disorder: Emergence of overvaluation of shape/weight by Kambanis, P Evelyna, Mancuso, Christopher J, Becker, Kendra R, Eddy, Kamryn T, Thomas, Jennifer J, De Young, Kyle P

“…Avoidant/restrictive food intake disorder (ARFID) is a feeding/eating disorder characterized by avoidance/restriction of food intake by volume and/or variety…”
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Disrupted Membrane Homeostasis and Accumulation of Ubiquitinated Proteins in a Mouse Model of Infantile Neuroaxonal Dystrophy Caused by PLA2G6 Mutations by Malik, Ibrahim, Turk, John, Mancuso, David J, Montier, Laura, Wohltmann, Mary, Wozniak, David F, Schmidt, Robert E, Gross, Richard W, Kotzbauer, Paul T

“…Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA2 β), were recently identified in patients with infantile…”
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First study demonstrating speckle tracking echocardiography has prognostic value in patients with idiopathic inflammatory myopathies by Machado, Luiz S. G., Oliveira, Ana C. D., Mancuso, Frederico J. N., Sato, Emilia I.

“…To measure left ventricular (LV) global longitudinal strain (GLS) using speckle tracking echocardiography in idiopathic inflammatory myopathy (IIM) patients…”
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Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation by Liu, Xinping, Moon, Sung Ho, Mancuso, David J., Jenkins, Christopher M., Guan, Shaoping, Sims, Harold F., Gross, Richard W.

“…A highly sensitive, specific, and robust method for the analysis of oxidized metabolites of linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid…”
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Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls by Eddy, Kamryn T., Plessow, Franziska, Breithaupt, Lauren, Becker, Kendra R., Slattery, Meghan, Mancuso, Christopher J., Izquierdo, Alyssa M., Van De Water, Avery L., Kahn, Danielle L., Dreier, Melissa J., Ebrahimi, Seda, Deckersbach, Thilo, Thomas, Jennifer J., Holsen, Laura M., Misra, Madhusmita, Lawson, Elizabeth A.

“…Anorexia nervosa (AN) and atypical AN (AtypAN) are complex neurobiological illnesses that typically onset in adolescence with an often treatment-refractory and…”
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An Outbreak of Multidrug-Resistant Acinetobacter baumannii-calcoaceticus Complex Infection in the US Military Health Care System Associated with Military Operations in Iraq by Scott, Paul, Deye, Gregory, Srinivasan, Arjun, Murray, Clinton, Moran, Kimberly, Hulten, Ed, Fishbain, Joel, Craft, David, Riddell, Scott, Lindler, Luther, Mancuso, James, Milstrey, Eric, Bautista, Christian T., Patel, Jean, Ewell, Alessa, Hamilton, Tacita, Gaddy, Charla, Tenney, Martin, Christopher, George, Petersen, Kyle, Endy, Timothy, Petruccelli, Bruno

“…Background. We investigated an outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection among US service members injured in…”
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Sociopolitical intellectual humility as a predictor of political attitudes and behavioral intentions by Krumrei-Mancuso, Elizabeth J., Newman, Brian

“…Recent research has highlighted the relevance of intellectual humility to politics. Among a U.S. sample (N = 852), we examined self-reported sociopolitical…”
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SARS-CoV-2 and Plasmodium falciparum common immunodominant regions may explain low COVID-19 incidence in the malaria-endemic belt by Iesa, M.A.M., Osman, M.E.M., Hassan, M.A., Dirar, A.I.A., Abuzeid, N., Mancuso, J.J., Pandey, R., Mohammed, A.A., Borad, M.J., Babiker, H.M., Konozy, E.H.E.

“…Coronavirus disease 2019 (COVID-19) has caused significant morbidity and mortality and new cases are on the rise globally, yet malaria-endemic areas report…”
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17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli by Palmer, Christine D., Mancuso, Christy J., Weiss, Jerrold P., Serhan, Charles N., Guinan, Eva C., Levy, Ofer

“…Lipoxins and resolvins regulate primary human mϕ responses to E. coli to enhance TNF production and phagocytic killing while reducing TNF production to…”
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A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses by Kronforst, Kenny D, Mancuso, Christy J, Pettengill, Matthew, Ninkovic, Jana, Power Coombs, Melanie R, Stevens, Chad, Otto, Michael, Mallard, Carina, Wang, Xiaoyang, Goldmann, Donald, Levy, Ofer

“…Staphylococcus epidermidis (SE) causes late onset sepsis and significant morbidity in catheterized preterm newborns. Animal models of SE infection are useful…”
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