Search Results - "MAMANE, Yael"

eIF4E - from translation to transformation by Mamane, Yaël, Petroulakis, Emmanuel, Rong, Liwei, Yoshida, Kaori, Ler, Lian Wee, Sonenberg, Nahum

“…Over the years, studies have focused on the transcriptional regulation of oncogenesis. More recently, a growing emphasis has been placed on translational…”
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Multiple Regulatory Domains Control IRF-7 Activity in Response to Virus Infection by Lin, Rongtuan, Mamane, Yael, Hiscott, John

“…Recent studies implicate the interferon regulatory factors (IRF), IRF-3 and IRF-7, as key activators of Type 1 interferon genes, as well as the RANTES…”
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Connexin43 pseudogene in breast cancer cells offers a novel therapeutic target by Bier, Andrew, Oviedo-Landaverde, Irene, Zhao, Jing, Mamane, Yael, Kandouz, Mustapha, Batist, Gerald

“…Connexin43 ( Cx43 ) is often deregulated in breast cancer tissue compared with normal adjacent tissue. Stable reexpression of Cx43 in cancer slows growth and…”
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Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains by Lin, Rongtuan, Mamane, Yael, Hiscott, John

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y by Robichaud, Joël, Fournier, Jean-François, Gagné, Sébastien, Gauthier, Jacques Yves, Hamel, Martine, Han, Yongxin, Hénault, Martin, Kargman, Stacia, Levesque, Jean-François, Mamane, Yaël, Mancini, Joseph, Morin, Nicolas, Mulrooney, Erin, Wu, Jin, Black, W. Cameron

“…Our series of competitive antagonists against the G-protein coupled receptor P2Y₁₄ were found to be highly shifted in the presence of serum (>99% protein…”
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HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators by RONGTUAN LIN, GENIN, Pierre, MAMANE, Yael, SGARBANTI, Marco, BATTISTINI, Angela, HARRINGTON, William J, BARBER, Glen N, HISCOTT, John

“…Human herpes virus 8 (HHV-8) has developed unique mechanisms for altering cellular proliferative and apoptotic control pathways by incorporating viral homologs…”
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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14 by YVES GAUTHIER, Jacques, BELLEY, Michel, LAVALLEE, Geneviève, LEVESQUE, Jean-François, LIANHAI LI, MAMANE, Yael, MANCINI, Joseph, MORIN, Nicolas, MULROONEY, Erin, ROBICHAUD, Joel, THERIEN, Michel, TRANMER, Geoffrey, DESCHENES, Denis, ZHAOYIN WANG, JIN WU, BLACK, W. Cameron, FOURNIER, Jean-François, GAGNE, Sébastien, GAREAU, Yves, HAMEL, Martine, HENAULT, Martin, HYJAZIE, Huda, KARGMAN, Stacia

“…A weak, UDP-competitive antagonist of the pyrimidinergic receptor P2RY(14) with a naphthoic acid core was identified through high-throughput screening…”
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Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines by ARGUELLO, Meztli, SGARBANTI, Marco, HERNANDEZ, Eduardo, MAMANE, Yael, SHARMA, Sonia, SERVANT, Marc, RONGTUAN LIN, HISCOTT, John

“…Primary effusion lymphoma (PEL) is a lymphoproliferative disease of B-cell origin that is associated with HHV-8 infection. PEL cells harbor a non-B, non-T…”
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The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation by Mamane, Yaël, Chung Chan, Chi, Lavallee, Genevieve, Morin, Nicolas, Xu, Li-Jing, Huang, JingQi, Gordon, Robert, Thomas, Winston, Lamb, John, Schadt, Eric E, Kennedy, Brian P, Mancini, Joseph A

“…The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation Yaël…”
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Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation by Mamane, Yaël, Petroulakis, Emmanuel, Martineau, Yvan, Sato, Taka-Aki, Larsson, Ola, Rajasekhar, Vinagolu K, Sonenberg, Nahum

“…Translation deregulation is an important mechanism that causes aberrant cell growth, proliferation and survival. eIF4E, the mRNA 5' cap-binding protein, plays…”
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When translation arises from its TORpor by Le Bacquer, Olivier, Martineau, Yvan, Mamane, Yaël

“…Gene regulation by transcriptional and post-translational mechanisms is implicated in the regulation of cellular homeostasis. Transcriptional deregulation has…”
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p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs by Petroulakis, Emmanuel, Parsyan, Armen, Dowling, Ryan J.O., LeBacquer, Olivier, Martineau, Yvan, Bidinosti, Michael, Larsson, Ola, Alain, Tommy, Rong, Liwei, Mamane, Yaël, Paquet, Marilene, Furic, Luc, Topisirovic, Ivan, Shahbazian, David, Livingstone, Mark, Costa-Mattioli, Mauro, Teodoro, Jose G., Sonenberg, Nahum

“…eIF4E, the mRNA 5′ cap-binding translation initiation factor, is overexpressed in numerous cancers and is implicated in mechanisms underlying oncogenesis and…”
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CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition by Gallo, David, Young, Jordan T. F., Fourtounis, Jimmy, Martino, Giovanni, Álvarez-Quilón, Alejandro, Bernier, Cynthia, Duffy, Nicole M., Papp, Robert, Roulston, Anne, Stocco, Rino, Szychowski, Janek, Veloso, Artur, Alam, Hunain, Baruah, Prasamit S., Fortin, Alexanne Bonneau, Bowlan, Julian, Chaudhary, Natasha, Desjardins, Jessica, Dietrich, Evelyne, Fournier, Sara, Fugère-Desjardins, Chloe, Goullet de Rugy, Theo, Leclaire, Marie-Eve, Liu, Bingcan, Bhaskaran, Vivek, Mamane, Yael, Melo, Henrique, Nicolas, Olivier, Singhania, Akul, Szilard, Rachel K., Tkáč, Ján, Yin, Shou Yun, Morris, Stephen J., Zinda, Michael, Marshall, C. Gary, Durocher, Daniel

“…Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours…”
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RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors by Roulston, Anne, Zimmermann, Michal, Papp, Robert, Skeldon, Alexander, Pellerin, Charles, Dumas-Bérube, Émilie, Dumais, Valerie, Dorich, Stéphane, Fader, Lee D, Fournier, Sara, Li, Li, Leclaire, Marie-Eve, Yin, Shou Yun, Chefson, Amandine, Alam, Hunain, Yang, William, Fugère-Desjardins, Chloe, Vignini-Hammond, Sabrina, Skorey, Kathryn, Mulani, Amina, Rimkunas, Victoria, Veloso, Artur, Hamel, Martine, Stocco, Rino, Mamane, Yael, Li, Zuomei, Young, Jordan T F, Zinda, Michael, Black, W Cameron

“…Ataxia telangiectasia and Rad3-related (ATR) kinase protects genome integrity during DNA replication. RP-3500 is a novel, orally bioavailable clinical-stage…”
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Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7 by Lin, Rongtuan, Génin, Pierre, Mamane, Yaël, Hiscott, John

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y by Gauthier, Jacques Yves, Belley, Michel, Deschênes, Denis, Fournier, Jean-François, Gagné, Sébastien, Gareau, Yves, Hamel, Martine, Hénault, Martin, Hyjazie, Huda, Kargman, Stacia, Lavallée, Geneviève, Levesque, Jean-François, Li, Lianhai, Mamane, Yaël, Mancini, Joseph, Morin, Nicolas, Mulrooney, Erin, Robichaud, Joël, Thérien, Michel, Tranmer, Geoffrey, Wang, Zhaoyin, Wu, Jin, Black, W. Cameron

“…A weak, UDP-competitive antagonist of the pyrimidinergic receptor P2RY₁₄ with a naphthoic acid core was identified through high-throughput screening…”
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Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ by Bubenik, Monica, Mader, Pavel, Mochirian, Philippe, Vallée, Fréderic, Clark, Jillian, Truchon, Jean-François, Perryman, Alexander L., Pau, Victor, Kurinov, Igor, Zahn, Karl E., Leclaire, Marie-Eve, Papp, Robert, Mathieu, Marie-Claude, Hamel, Martine, Duffy, Nicole M., Godbout, Claude, Casas-Selves, Matias, Falgueyret, Jean-Pierre, Baruah, Prasamit S., Nicolas, Olivier, Stocco, Rino, Poirier, Hugo, Martino, Giovanni, Fortin, Alexanne Bonneau, Roulston, Anne, Chefson, Amandine, Dorich, Stéphane, St-Onge, Miguel, Patel, Purvish, Pellerin, Charles, Ciblat, Stéphane, Pinter, Thomas, Barabé, Francis, El Bakkouri, Majida, Parikh, Paranjay, Gervais, Christian, Sfeir, Agnel, Mamane, Yael, Morris, Stephen J., Black, W. Cameron, Sicheri, Frank, Gallant, Michel

“…DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers…”
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Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306 by Szychowski, Janek, Papp, Robert, Dietrich, Evelyne, Liu, Bingcan, Vallée, Frédéric, Leclaire, Marie-Eve, Fourtounis, Jimmy, Martino, Giovanni, Perryman, Alexander L., Pau, Victor, Yin, Shou Yun, Mader, Pavel, Roulston, Anne, Truchon, Jean-Francois, Marshall, C. Gary, Diallo, Mohamed, Duffy, Nicole M., Stocco, Rino, Godbout, Claude, Bonneau-Fortin, Alexanne, Kryczka, Rosie, Bhaskaran, Vivek, Mao, Daniel, Orlicky, Stephen, Beaulieu, Patrick, Turcotte, Pascal, Kurinov, Igor, Sicheri, Frank, Mamane, Yael, Gallant, Michel, Black, W. Cameron

“…PKMYT1 is a regulator of CDK1 phosphorylation and is a compelling therapeutic target for the treatment of certain types of DNA damage response cancers due to…”
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Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500) by Black, W. Cameron, Abdoli, Abbas, An, Xiuli, Auger, Anick, Beaulieu, Patrick, Bernatchez, Michel, Caron, Cathy, Chefson, Amandine, Crane, Sheldon, Diallo, Mohamed, Dorich, Stéphane, Fader, Lee D., Ferraro, Gino B., Fournier, Sara, Gao, Qi, Ginzburg, Yelena, Hamel, Martine, Han, Yongshuai, Jones, Paul, Lanoix, Stéphanie, Lacbay, Cyrus M., Leclaire, Marie-Eve, Levy, Maayan, Mamane, Yael, Mulani, Amina, Papp, Robert, Pellerin, Charles, Picard, Audrey, Skeldon, Alexander, Skorey, Kathryn, Stocco, Rino, St.-Onge, Miguel, Truchon, Jean-François, Truong, Vouy Linh, Zimmermann, Michal, Zinda, Michael, Roulston, Anne

“…ATR is a key kinase in the DNA-damage response (DDR) that is synthetic lethal with several other DDR proteins, making it an attractive target for the treatment…”
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Abstract P054: RP-3500: A novel, potent and selective ATR inhibitor that is effective in pre-clinical models as a monotherapy and in combination with PARP inhibitors by Roulston, Anne, Zimmerman, Michal, Papp, Robert, Skeldon, Alex, Pellerin, Charles, Dumas-Bérube, Émilie, Dumais, Valerie, Dorich, Stephane, Fournier, Sara, Li, Li, Leclaire, Marie-Ève, Yin, Shou Yun, Chefson, Amandine, Alam, Hunain, Yang, William, Fugère-Desjardins, Chloe, Hammond, Sabrina, Skorey, Kathryn, Mulani, Amina, Rimkunas, Victoria, Veloso, Artur, Hamel, Martine, Stocco, Rino, Mamane, Yael, Li, Zuomei, Young, Jordan, Zinda, Mike, Black, Cameron

“…Abstract Background: Ataxia telangiectasia and Rad3-related (ATR) protein kinase is a key mediator of cellular DNA damage repair (DDR) and is activated in…”
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