Search Results - "MALVY, Claude"

Plasma hydrogenated cationic detonation nanodiamonds efficiently deliver to human cells in culture functional siRNA targeting the Ewing sarcoma junction oncogene by Bertrand, Jean-Rémi, Pioche-Durieu, Catherine, Ayala, Juan, Petit, Tristan, Girard, Hugues A, Malvy, Claude P, Le Cam, Eric, Treussart, François, Arnault, Jean-Charles

“…Abstract The expression of a defective gene can lead to major cell dysfunctions among which cell proliferation and tumor formation. One promising therapeutic…”
Get full text

Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells by Alhaddad, Anna, Adam, Marie-Pierre, Botsoa, Jacques, Dantelle, Géraldine, Perruchas, Sandrine, Gacoin, Thierry, Mansuy, Christelle, Lavielle, Solange, Malvy, Claude, Treussart, François, Bertrand, Jean-Rémi

“…The ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) into Ewing sarcoma cells is investigated with a view to the…”
Get full text

Influence of the internalization pathway on the efficacy of siRNA delivery by cationic fluorescent nanodiamonds in the Ewing sarcoma cell model by Alhaddad, Anna, Durieu, Catherine, Dantelle, Géraldine, Le Cam, Eric, Malvy, Claude, Treussart, François, Bertrand, Jean-Rémi

“…Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to…”
Get full text

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo by Bertrand, Jean-Rémi, Pottier, Mireille, Vekris, Antoine, Opolon, Paule, Maksimenko, Andrei, Malvy, Claude

“…Efficiencies of a nuclease resistant antisense oligonucleotide and of siRNA both being targeted against the green fluorescent protein stably expressed in HeLa…”
Get full text

Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in ewing sarcoma by TOUB, Nedjma, BERTRAND, Jean-Rémi, TAMADDON, Ali, ELHAMESS, Hind, HILLAIREAU, Hervé, MAKSIMENKO, Andrei, MACCARIO, Jean, MALVY, Claude, FATTAL, Elias, COUVREUR, Patrick

“…The EWS-Fli1 fusion gene encodes for a chimeric oncogenic transcription factor considered to be the cause of the Ewing sarcoma. The efficiency of small…”
Get full text

The high stability of the triple helices formed between short purine oligonucleotides and SIV/HIV-2 vpx genes is determined by the targeted DNA structure by Svinarchuk, Fedor, Monnot, Monique, Merle, AurelIe, Malvy, Claude, Fermandjian, Serge

“…In our previous works we have shown that the oligonucleotides 5′-GGGGAGGGGGAGG-3′ and 5′-GGAGGGGGAGGGG-3′ give very stable and specific triplexes with their…”
Get full text

An Unusually Stable Purine(Purine-Pyrimidine) Short Triplex by Svinarchuk, Fedor, Paoletti, Jacques, Malvy, Claude

“…Classical models for DNA triple helix formation assume the stabilization of these structures through the formation of Hoogsteen hydrogen bonds. This assumes…”
Get full text

Presence of Divalent Cation Is Not Mandatory for the Formation of Intramolecular Purine-Motif Triplex Containing Human c-jun Protooncogene Target by Kaushik, Shikha, Kaushik, Mahima, Svinarchuk, Fedor, Malvy, Claude, Fermandjian, Serge, Kukreti, Shrikant

“…Modulation of endogenous gene function, through sequence-specific recognition of double helical DNA via oligonucleotide-directed triplex formation, is a…”
Get full text

Effects of silencing RET/PTC1 junction oncogene in human papillary thyroid carcinoma cells by Gilbert-Sirieix, Marie, Ripoche, Hugues, Malvy, Claude, Massaad-Massade, Liliane

“…RET/PTC1 rearrangement is the most common genetic alteration identified to date in papillary thyroid carcinomas (PTC) and represents an interesting target for…”
Get more information

siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma by de Martimprey, Henri, Bertrand, Jean-Remi, Fusco, Alfredo, Santoro, Massimo, Couvreur, Patrick, Vauthier, Christine, Malvy, Claude

“…Delivery is a very important concern for therapeutic applications of siRNA. In this study, we have used chitosan-coated poly(isobutylcyanoacrylate)…”
Get full text

New Core-Shell Nanoparticules for the Intravenous Delivery of siRNA to Experimental Thyroid Papillary Carcinoma by de Martimprey, Henri, Bertrand, Jean-Rémi, Malvy, Claude, Couvreur, Patrick, Vauthier, Christine

“…Purpose Development of efficient in vivo delivery nanodevices remains a major challenge to achieve clinical application of siRNA. The present study refers to…”
Get full text

Nanotechnologies for drug delivery: Application to cancer and autoimmune diseases by Couvreur, P., Gref, R., Andrieux, K., Malvy, C.

“…Polymer-based nanotechnologies are now proposed as an alternative to classical formulations for drug administration, delivery and targeting. Therapeutic…”
Get full text

Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells by Bertrand, Jean-Rémi, Lucas, Claire, Pham, Ngoc Minh, Durieu, Catherine, Couvreur, Patrick, Malvy, Claude Paul, Desmaële, Didier

“…Covalent binding of squalene to siRNA has already been shown to be an interesting way of delivering siRNA in vivo. Whether squalene derivatives could also be…”
Get more information

Oncogene-targeted antisense oligonucleotides for the treatment of Ewing sarcoma by Maksimenko, Andrei, Malvy, Claude

“…The genetic hallmark of the Ewing sarcoma family of tumours (ESFT) is the presence of the t(11;22)(q24;q12) translocation, present in up to 85% of cases of…”
Get more information

Corrigendum: Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells by Alhaddad, Anna, Adam, Marie-Pierre, Botsoa, Jacques, Dantelle, Géraldine, Perruchas, Sandrine, Gacoin, Thierry, Mansuy, Christelle, Lavielle, Solange, Malvy, Claude, Treussart, François, Bertrand, Jean-Rémi

Get full text

Efficacy of dendrimer‐mediated angiostatin and TIMP‐2 gene delivery on inhibition of tumor growth and angiogenesis: In vitro and in vivo studies by Vincent, Loïc, Varet, Julia, Pille, Jean‐Yves, Bompais, Heidi, Opolon, Paule, Maksimenko, Andrei, Malvy, Claude, Mirshahi, Manouchehr, Lu, He, Vannier, Jean‐Pierre, Soria, Claudine, Li, Hong

“…Gene transfer is an attractive approach to fight cancer by targeting cancer cells or their vasculature. Our study reports the inhibition of tumor growth and…”
Get full text

EWS Fli-1 Antisense Nanocapsules Inhibits Ewing Sarcoma-Related Tumor in Mice by Lambert, Gregory, Bertrand, Jean Rémi, Fattal, Elias, Subra, Frédéric, Pinto-Alphandary, Huguette, Malvy, Claude, Auclair, Christian, Couvreur, Patrick

“…EWS Fli-1, a fusion gene resulting from a t(11;22) translocation is found in 90% of both Ewing's sarcoma and primitive neuroectodermal tumor (PNET). In the…”
Get full text

Optimisation of dendrimer-mediated gene transfer by anionic oligomers by Maksimenko, Andrei V., Mandrouguine, Vasilii, Gottikh, Marina B., Bertrand, Jean-Remi, Majoral, Jean-Pierre, Malvy, Claude

“…Background The application of synthetic vectors for gene transfer has potential advantages over virus‐based systems. Their use, however, is limited since they…”
Get full text

Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides by Fattal, Elias, Vauthier, Christine, Aynie, Isabelle, Nakada, Yuichiro, Lambert, Gregory, Malvy, Claude, Couvreur, Patrick

“…Antisense oligonucleotides with base sequences complementary to a specific RNA can, after binding to intracellular mRNA, selectively modulate the expression of…”
Get full text

In Vivo Potentialities of EWS-Fli-1 Targeted Antisense Oligonucleotides-Nanospheres Complexes by MAKSIMENKO, ANDREI, POLARD, VALERIE, VILLEMEUR, MARIE, ELHAMESS, HIND, COUVREUR, PATRICK, BERTRAND, JEAN-REMI, ABOUBAKAR, MALAM, GOTTIKH, MARINA, MALVY, CLAUDE

“…The EWS/FLI‐1 fusion gene, resulting from a t(11;22) translocation, plays a key role in the pathogenesis of Ewing sarcoma. Previously, we have shown that…”
Get full text