Search Results - "MALLER, Ori"

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression by Maller, Ori, Drain, Allison P., Barrett, Alexander S., Borgquist, Signe, Ruffell, Brian, Zakharevich, Igor, Pham, Thanh T., Gruosso, Tina, Kuasne, Hellen, Lakins, Johnathon N., Acerbi, Irene, Barnes, J. Matthew, Nemkov, Travis, Chauhan, Aastha, Gruenberg, Jessica, Nasir, Aqsa, Bjarnadottir, Olof, Werb, Zena, Kabos, Peter, Chen, Yunn-Yi, Hwang, E. Shelley, Park, Morag, Coussens, Lisa M., Nelson, Andrew C., Hansen, Kirk C., Weaver, Valerie M.

“…Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate…”
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A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma by Barnes, J. Matthew, Kaushik, Shelly, Bainer, Russell O., Sa, Jason K., Woods, Elliot C., Kai, FuiBoon, Przybyla, Laralynne, Lee, Mijeong, Lee, Hye Won, Tung, Jason C., Maller, Ori, Barrett, Alexander S., Lu, Kan V., Lakins, Jonathon N., Hansen, Kirk C., Obernier, Kirsten, Alvarez-Buylla, Arturo, Bergers, Gabriele, Phillips, Joanna J., Nam, Do-Hyun, Bertozzi, Carolyn R., Weaver, Valerie M.

“…Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their…”
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Extracellular Matrix Composition Reveals Complex and Dynamic Stromal-Epithelial Interactions in the Mammary Gland by Maller, Ori, Martinson, Holly, Schedin, Pepper

“…The mammary gland is an excellent model system to study the interplay between stroma and epithelial cells because of the gland’s unique postnatal development…”
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The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis by Goddard, Erica T, Hill, Ryan C, Nemkov, Travis, D'Alessandro, Angelo, Hansen, Kirk C, Maller, Ori, Mongoue-Tchokote, Solange, Mori, Motomi, Partridge, Ann H, Borges, Virginia F, Schedin, Pepper

“…Patients with postpartum breast cancer are at increased risk for metastasis compared with age-matched nulliparous or pregnant patients. Here, we address…”
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An In-solution Ultrasonication-assisted Digestion Method for Improved Extracellular Matrix Proteome Coverage by Hansen, Kirk C., Kiemele, Lauren, Maller, Ori, O'Brien, Jenean, Shankar, Aarthi, Fornetti, Jaime, Schedin, Pepper

“…Epithelial cell behavior is coordinated by the composition of the surrounding extracellular matrix (ECM); thus ECM protein identification is critical for…”
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Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments by Goddard, Erica T., Hill, Ryan C., Barrett, Alexander, Betts, Courtney, Guo, Qiuchen, Maller, Ori, Borges, Virginia F., Hansen, Kirk C., Schedin, Pepper

“…Normal epithelium exists within a dynamic extracellular matrix (ECM) that is tuned to regulate tissue specific epithelial cell function. As such, ECM…”
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Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer by Drain, Allison P, Zahir, Nastaran, Northey, Jason J, Zhang, Hui, Huang, Po-Jui, Maller, Ori, Lakins, Johnathon N, Yu, Xinmiao, Leight, Jennifer L, Alston-Mills, Brenda P, Hwang, E Shelley, Chen, Yunn-Yi, Park, Catherine C, Weaver, Valerie M

“…Triple-negative breast cancers (TNBCs) are associated with poor survival mediated by treatment resistance. TNBCs are fibrotic, yet little is known regarding…”
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A phase 1 study of ADI-001: Anti-CD20 CAR-engineered allogeneic gamma delta (γδ) T cells in adults with B-cell malignancies by Neelapu, Sattva Swarup, Hamadani, Mehdi, Miklos, David Bernard, Holmes, Houston, Hinkle, John, Kennedy-Wilde, Jackie, Maller, Ori, Weinstein, Maggie, Galimi, Francesco, Lai, Rose, Stevens, Don A.

“…7509 Background: ADI-001 is a first-in-class allogeneic gamma delta (γδ) CAR T-cell therapy targeting the B-cell antigen CD20. ADI-001 also has both adaptive…”
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Collagen architecture in pregnancy-induced protection from breast cancer by Maller, Ori, Hansen, Kirk C, Lyons, Traci R, Acerbi, Irene, Weaver, Valerie M, Prekeris, Rytis, Tan, Aik-Choon, Schedin, Pepper

“…The reduction in breast cancer risk attributed to early-age pregnancy is mediated in part by changes in the mammary epithelium. Here, we address the role of…”
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A Phase 1 Study of ADI-001: Anti-CD20 CAR-Engineered Allogeneic Gamma Delta1 (γδ) T Cells in Adults with B-Cell Malignancies by Neelapu, Sattva S., Stevens, Don A., Hamadani, Mehdi, Frank, Matthew J., Holmes, Houston, Jacobovits, Aya, Hinkle, John, Kennedy-Wilde, Jackie, Maller, Ori, Weinstein, Bayarmagnai, Galimi, Francesco, Lai, Rose K., Miklos, David B.

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YAP forces fibroblasts to feel the tension by Maller, Ori, DuFort, Christopher C., Weaver, Valerie M.

“…Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and…”
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SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express IL12 and IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors by Gonzalez-Junca, Alba, Liu, Frances D, Nagaraja, Archana S, Mullenix, Alyssa, Lee, Chen-Ting, Gordley, Russell M, Frimannsson, Daniel O, Maller, Ori, Garrison, Brian S, Iyer, Dharini, Benabbas, Anissa, Truong, Tiffany A, Quach, Allison, Tian, Mengxi, Martinez, Rowena, Savur, Rishi, Perry-McNamara, Alyssa, Nguyen, Denny, Almudhfar, Niran, Blanco, Carmina, Huynh, Christina, Nand, Asish, Lay, Yu-An E, Magal, Ashita, Mangalampalli, Sravani, Lee, Philip J, Lu, Timothy K, Lee, Gary

“…Advanced peritoneal carcinomatosis including high-grade ovarian cancer has poor prognoses and a poor response rate to current checkpoint inhibitor…”
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Abstract 4246: SENTI-101, a novel genetically modified allogeneic cell product expressing IL12 and IL21, elicits a tumor-localized, robust, and multimodal immune response in preclinical models of solid tumors by Gonzalez, Alba, Liu, Frances D., Nagaraja, Archana, Mullenix, Alyssa, Gordley, Russell M., Frimannsson, Daniel O., Benabbas, Anissa, Lee, Chen-Ting, Truong, Tiffany A., Quach, Allison, Tian, Mengxi, Martinez, Rowena, Savur, Rishi, Perry-McNamara, Alyssa, Wang, Don-Hong, Maller, Ori, Iyer, Dharini, Magal, Ashita, Mangalampalli, Sravani, Huynh, Christina J., Blanco, Carmina C., Lin, Jack T., Garrison, Brian S., Lee, Philip, Lu, Timothy K., Lee, Gary

“…Abstract While immunotherapies based on single recombinant cytokines such as IL12 and IL21 have shown great promise in preclinical models of solid tumors,…”
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Tumor-associated macrophages restrict CD8 + T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment by Tharp, Kevin M, Kersten, Kelly, Maller, Ori, Timblin, Greg A, Stashko, Connor, Canale, Fernando P, Menjivar, Rosa E, Hayward, Mary-Kate, Berestjuk, Ilona, Ten Hoeve, Johanna, Samad, Bushra, Ironside, Alastrair J, di Magliano, Marina Pasca, Muir, Alexander, Geiger, Roger, Combes, Alexis J, Weaver, Valerie M

“…Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix accumulation, which is associated with diminished antitumor immune…”
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18 - A Phase 1 Study of ADI-001: Anti-CD20 CAR-Engineered Allogeneic Gamma Delta1 (γδ) T Cells in Adults with B-Cell Malignancies by Neelapu, Sattva S., Stevens, Don A., Hamadani, Mehdi, Frank, Matthew J., Holmes, Houston, Jacobovits, Aya, Hinkle, John, Kennedy-Wilde, Jackie, Maller, Ori, Weinstein, Bayarmagnai, Galimi, Francesco, Lai, Rose K, Miklos, David B.

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A Phase 1 Study of ADI-001: Anti-CD20 CAR-Engineered Allogeneic Gamma Delta1 (γδ) T Cells in Adults with B-Cell Malignancies by Neelapu, Sattva S., Stevens, Don A., Hamadani, Mehdi, Frank, Matthew J., Holmes, Houston, Jacobovits, Aya, Hinkle, John, Kennedy-Wilde, Jackie, Maller, Ori, Weinstein, Bayarmagnai, Galimi, Francesco, Lai, Rose K, Miklos, David B.

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Abstract B090: Collagen organization implicated in tumor dormancy by Maller, Ori, Hansen, Kirk C., Weaver, Valerie, Prekeris, Rytis, Schedin, Pepper

“…Abstract It is known that tumor cells can reside in a dormant state for decades. Data from numerous studies strongly suggest that extracellular matrix (ECM)…”
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Extracellular Matrix Composition Reveals Complex and Dynamic Stromal-Epithelial Interactions in the Mammary Gland: Stroma in Normal Mammary Gland Development and Function by MALLER, Ori, MARTINSON, Holly, SCHEDIN, Pepper

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Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes by Hattar, Rhonda, Maller, Ori, McDaniel, Shauntae, Hansen, Kirk C, Hedman, Karla J, Lyons, Traci R, Lucia, Scott, Wilson, Jr, R Storey, Schedin, Pepper

“…The functional unit of the mammary gland has been defined as the epithelial cell plus its microenvironment, a hypothesis that predicts changes in epithelial…”
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Compartment resolved proteomics reveals a dynamic matrisome in a biomechanically driven model of pancreatic ductal adenocarcinoma by Barrett, Alexander S, Maller, Ori, Pickup, Michael W, Weaver, Valerie M, Hansen, Kirk C

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by a severe fibrotic component that compromises treatment, alters the immune cell profile and…”
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