Search Results - "MALKINSON, M."

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation by Redente, Elizabeth F., Higgins, David M., Dwyer-Nield, Lori D., Orme, Ian M., Gonzalez-Juarrero, Mercedes, Malkinson, Alvin M.

“…Alveolar macrophages undergo similar polarization to chemically and pathogen‐induced chronic lung inflammation, but the phenotype of bone marrow‐derived…”
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Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas by Fritz, Jason M, Tennis, Meredith A, Orlicky, David J, Lin, Hao, Ju, Cynthia, Redente, Elizabeth F, Choo, Kevin S, Staab, Taylor A, Bouchard, Ronald J, Merrick, Daniel T, Malkinson, Alvin M, Dwyer-Nield, Lori D

“…Chronic inflammation is a risk factor for lung cancer, and low-dose aspirin intake reduces lung cancer risk. However, the roles that specific inflammatory…”
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Analysis of Orthologous Gene Expression between Human Pulmonary Adenocarcinoma and a Carcinogen-Induced Murine Model by Stearman, Robert S., Dwyer-Nield, Lori, Zerbe, Laura, Blaine, Stacy A., Chan, Zeng, Bunn, Paul A., Johnson, Gary L., Hirsch, Fred R., Merrick, Daniel T., Franklin, Wilbur A., Baron, Anna E., Keith, Robert L., Nemenoff, Raphael A., Malkinson, Alvin M., Geraci, Mark W.

“…Human adenocarcinoma (AC) is the most frequently diagnosed human lung cancer, and its absolute incidence is increasing dramatically. Compared to human lung AC,…”
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Effect of Silibinin on the Growth and Progression of Primary Lung Tumors in Mice by Singh, Rana P., Deep, Gagan, Chittezhath, Manesh, Kaur, Manjinder, Dwyer-Nield, Lori D., Malkinson, Alvin M., Agarwal, Rajesh

“…Background: Silibinin, a flavanone from milk thistle, inhibits the growth of tumors in several rodent models. We examined the effects of dietary silibinin on…”
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Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United States by Lanciotti, R. S., Roehrig, J. T., Deubel, V., Smith, J., Parker, M., Steele, K., Crise, B., Volpe, K. E., Crabtree, M. B., Scherret, J. H., Hall, R. A., MacKenzie, J. S., Cropp, C. B., Panigrahy, B., Ostlund, E., Schmitt, B., Malkinson, M., Banet, C., Weissman, J., Komar, N., Savage, H. M., Stone, W., McNamara, T., Gubler, D. J.

“…In late summer 1999, an outbreak of human encephalitis occurred in the northeastern United States that was concurrent with extensive mortality in crows (Corvus…”
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BARD1: An independent predictor of survival in non-small cell lung cancer by Zhang, Yong-Qiang, Bianco, Andrea, Malkinson, Alvin M., Leoni, Vera Piera, Frau, Gianni, De Rosa, Nicolina, André, Pierre-Alain, Versace, Renato, Boulvain, Michel, Laurent, Geoffrey J., Atzori, Luigi, Irminger-Finger, Irmgard

“…BRCA1 mRNA overexpression is correlated with poor survival in NSCLC. However, BRCA1 functions depend on the interaction with BARD1 for its stability, nuclear…”
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Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung by Malkinson, Alvin M.

“…Primary lung tumors in mice have morphologic, histogenic, and molecular features similar to human lung adenocarcinoma, and in particular, the…”
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The role of birds in the ecology of West Nile virus in Europe and Africa by Malkinson, M, Banet, C

“…Surveys on wild birds conducted during the last two decades in Europe, notably Poland and the Czech Republic, to determine their infection rate with WN virus…”
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Tumor Signaling to the Bone Marrow Changes the Phenotype of Monocytes and Pulmonary Macrophages during Urethane-Induced Primary Lung Tumorigenesis in A/J Mice by Redente, Elizabeth F, Orlicky, David J, Bouchard, Ronald J, Malkinson, Alvin M

“…Little is known about how the composition of stromal cells within the lung cancer microenvironment varies during tumor progression. We examined by…”
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Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation by Fritz, Jason M, Dwyer-Nield, Lori D, Malkinson, Alvin M

“…Worldwide, lung cancer kills more people than breast, colon and prostate cancer combined. Alterations in macrophage number and function during lung…”
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Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities by Bauer, Alison K, Malkinson, Alvin M, Kleeberger, Steven R

“…Chronic inflammation predisposes toward many types of cancer. Chronic bronchitis and asthma, for example, heighten the risk of lung cancer. Exactly which…”
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A Macrophage Gene Expression Signature Defines a Field Effect in the Lung Tumor Microenvironment by STEARMAN, Robert S, DWYER-NIELD, Lori, GRADY, Michael C, MALKINSON, Alvin M, GERACI, Mark W

“…One area of intensive investigation is to understand complex cellular and signaling interactions in the tumor microenvironment. Using a novel, although…”
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Epistatic interactions govern chemically‐induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J‐ChrA/J chromosome substitution strains by Dwyer‐Nield, Lori D., McQuillan, Jay, Hill‐Baskin, Annie, Radcliffe, Richard A., You, Ming, Nadeau, Joseph H., Malkinson, Alvin M.

“…Cancer susceptibility results from interactions between sensitivity and resistance alleles. We employed murine chromosome substitution strains to study how…”
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High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors by Bauer, Alison K., Dwyer-Nield, Lori D., Malkinson, Alvin M.

“…Mouse lung tumorigenesis is a convenient model for examining all stages of lung adenocarcinoma (AC) progression. Because enhanced cyclooxygenase 2 (COX-2)…”
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Calpain activation in apoptosis by Squìer, M K, Miller, A C, Malkinson, A M, Cohen, J J

“…Programmed cell death is an active process wherein the cell initiates a sequence of events culminating in the fragmentation of its DNA, nuclear collapse, and…”
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Clara cell: Progenitor for the bronchiolar epithelium by Reynolds, Susan D., Malkinson, Alvin M.

“…Clara cells were first described as a morphologically distinct cell type by Kolliker in 1881, but they take their name from the seminal study of human and…”
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Surfactant Protein C Expression in Urethane-Induced Murine Pulmonary Tumors by Mason, Robert J., Kalina, Moshe, Nielsen, Larry D., Malkinson, Alvin M., Shannon, John M.

“…Mice injected with urethane develop tumors with distinct histological patterns, which are classified as solid, papillary, or a mixture of these two patterns…”
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Molecular Comparison of Human and Mouse Pulmonary Adenocarcinomas by Malkinson, Alvin M.

“…Mice develop lung tumors similar in their histogenesis and molecular features to peripheral adenocarcinomas in humans. The advantage of this model system is…”
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Mouse lung epithelial cell lines—tools for the study of differentiation and the neoplastic phenotype by Malkinson, Alvin M, Dwyer-Nield, Lori D, Rice, Pamela L, Dinsdale, David

“…Several dozen lung epithelial cell lines have been established in culture over the past 20 years from normal lung explants and their spontaneous transformants,…”
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Toll-Like Receptor 4 in Butylated Hydroxytoluene–Induced Mouse Pulmonary Inflammation and Tumorigenesis by Bauer, Alison K., Dixon, Darlene, DeGraff, Laura M., Cho, Hye-Youn, Walker, Christopher R., Malkinson, Alvin M., Kleeberger, Steven R.

“…Because chronic pulmonary diseases predispose to lung neoplasia, the identification of the molecular mechanisms involved could provide novel preventive,…”
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