Search Results - "MALHOTRA, Dheeraj"

CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics by Malhotra, Dheeraj, Sebat, Jonathan

“…The genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry. Genome-wide studies of copy number variation (CNV) have given…”
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muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data by Crowell, Helena L., Soneson, Charlotte, Germain, Pierre-Luc, Calini, Daniela, Collin, Ludovic, Raposo, Catarina, Malhotra, Dheeraj, Robinson, Mark D.

“…Single-cell RNA sequencing (scRNA-seq) has become an empowering technology to profile the transcriptomes of individual cells on a large scale. Early analyses…”
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An intelligent approach to design of E-Commerce metasearch and ranking system using next-generation big data analytics by Malhotra, Dheeraj, Rishi, Omprakash

“…The purpose of this research work is to explore various limitations of conventional search and page ranking systems in an E-Commerce environment. The key…”
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Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation by Michaelson, Jacob J., Shi, Yujian, Gujral, Madhusudan, Zheng, Hancheng, Malhotra, Dheeraj, Jin, Xin, Jian, Minghan, Liu, Guangming, Greer, Douglas, Bhandari, Abhishek, Wu, Wenting, Corominas, Roser, Peoples, Áine, Koren, Amnon, Gore, Athurva, Kang, Shuli, Lin, Guan Ning, Estabillo, Jasper, Gadomski, Therese, Singh, Balvindar, Zhang, Kun, Akshoomoff, Natacha, Corsello, Christina, McCarroll, Steven, Iakoucheva, Lilia M., Li, Yingrui, Wang, Jun, Sebat, Jonathan

“…De novo mutation plays an important role in autism spectrum disorders (ASDs). Notably, pathogenic copy number variants (CNVs) are characterized by high…”
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Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression by Rexach, Jessica E., Polioudakis, Damon, Yin, Anna, Swarup, Vivek, Chang, Timothy S., Nguyen, Tam, Sarkar, Arjun, Chen, Lawrence, Huang, Jerry, Lin, Li-Chun, Seeley, William, Trojanowski, John Q., Malhotra, Dheeraj, Geschwind, Daniel H.

“…To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional…”
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Machine Learning and Artificial Intelligence in the Food Industry: A Sustainable Approach by Kler, Rajnish, Elkady, Ghada, Rane, Kantilal, Singh, Abha, Hossain, Md Shamim, Malhotra, Dheeraj, Ray, Samrat, Bhatia, Komal Kumar

“…The goal of this research was to look into how artificial intelligence (AI) and machine learning (ML) techniques are being used in food industry and to come up…”
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High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia by Malhotra, Dheeraj, McCarthy, Shane, Michaelson, Jacob J., Vacic, Vladimir, Burdick, Katherine E., Yoon, Seungtai, Cichon, Sven, Corvin, Aiden, Gary, Sydney, Gershon, Elliot S., Gill, Michael, Karayiorgou, Maria, Kelsoe, John R., Krastoshevsky, Olga, Krause, Verena, Leibenluft, Ellen, Levy, Deborah L., Makarov, Vladimir, Bhandari, Abhishek, Malhotra, Anil K., McMahon, Francis J., Nöthen, Markus M., Potash, James B., Rietschel, Marcella, Schulze, Thomas G., Sebat, Jonathan

“…While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is…”
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Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia by Walsh, Tom, McClellan, Jon M., McCarthy, Shane E., Addington, Anjené M., Pierce, Sarah B., Cooper, Greg M., Nord, Alex S., Kusenda, Mary, Malhotra, Dheeraj, Bhandari, Abhishek, Stray, Sunday M., Rippey, Caitlin F., Roccanova, Patricia, Makarov, Vlad, Lakshmi, B., Findling, Robert L., Sikich, Linmarie, Stromberg, Thomas, Merriman, Barry, Gogtay, Nitin, Butler, Philip, Eckstrand, Kristen, Noory, Laila, Gochman, Peter, Long, Robert, Chen, Zugen, Davis, Sean, Baker, Carl, Eichler, Evan E., Meltzer, Paul S., Nelson, Stanley F., Singleton, Andrew B., Lee, Ming K., Rapoport, Judith L., King, Mary-Claire, Sebat, Jonathan

“…Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. We hypothesize that individually rare structural variants…”
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Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia by Sebat, Jonathan, Vacic, Vladimir, McCarthy, Shane, Malhotra, Dheeraj, Murray, Fiona, Chou, Hsun-Hua, Peoples, Aine, Makarov, Vladimir, Yoon, Seungtai, Bhandari, Abhishek, Corominas, Roser, Iakoucheva, Lilia M, Krastoshevsky, Olga, Krause, Verena, Larach-Walters, Verónica, Welsh, David K, Craig, David, Kelsoe, John R, Gershon, Elliot S, Leal, Suzanne M, Aquila, Marie Dell, Morris, Derek W, Gill, Michael, Corvin, Aiden, Insel, Paul A, McClellan, Jon, King, Mary-Claire, Karayiorgou, Maria, Levy, Deborah L, DeLisi, Lynn E

“…Rare copy number variants (CNVs) have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for…”
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Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism by Corominas, Roser, Yang, Xinping, Lin, Guan Ning, Kang, Shuli, Shen, Yun, Ghamsari, Lila, Broly, Martin, Rodriguez, Maria, Tam, Stanley, Wanamaker, Shelly A., Fan, Changyu, Yi, Song, Tasan, Murat, Lemmens, Irma, Kuang, Xingyan, Zhao, Nan, Malhotra, Dheeraj, Michaelson, Jacob J., Vacic, Vladimir, Calderwood, Michael A., Roth, Frederick P., Tavernier, Jan, Horvath, Steve, Salehi-Ashtiani, Kourosh, Korkin, Dmitry, Sebat, Jonathan, Hill, David E., Hao, Tong, Vidal, Marc, Iakoucheva, Lilia M.

“…Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci . The convergence of ASD variants have been investigated using…”
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IMSS-P: An intelligent approach to design & development of personalized meta search & page ranking system by Malhotra, Dheeraj, Rishi, O.P.

“…The proposed research work aims to discuss and explore various constraints of traditional web page search and ranking systems primarily in the present…”
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Machine Learning Integrated Multivariate Water Quality Control Framework for Prawn Harvesting from Fresh Water Ponds by Kaur, Gaganpreet, Braveen, M., Krishnapriya, Singamaneni, Wawale, Surindar Gopalrao, Castillo-Picon, Jorge, Malhotra, Dheeraj, Osei-Owusu, Jonathan

“…Water contamination, temperature imbalance, feed, space, and cost are key issues that traditional fish farming encounters. The aquaculture business still…”
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Author Correction: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism by Corominas, Roser, Yang, Xinping, Lin, Guan Ning, Kang, Shuli, Shen, Yun, Ghamsari, Lila, Broly, Martin, Rodriguez, Maria, Tam, Stanley, Wanamaker, Shelly A., Fan, Changyu, Yi, Song, Tasan, Murat, Lemmens, Irma, Kuang, Xingyan, Zhao, Nan, Malhotra, Dheeraj, Michaelson, Jacob J., Vacic, Vladimir, Calderwood, Michael A., Roth, Frederick P., Tavernier, Jan, Horvath, Steve, Salehi-Ashtiani, Kourosh, Korkin, Dmitry, Sebat, Jonathan, Hill, David E., Hao, Tong, Vidal, Marc, Iakoucheva, Lilia M.

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Reduced transcript expression of genes affected by inherited and de novo CNVs in autism by NORD, Alex S, ROEB, Wendy, SEBAT, Jonathan, KING, Bryan, KING, Mary-Claire, MCCLELLAN, Jon M, DICKEL, Diane E, WALSH, Tom, KUSENDA, Mary, O'CONNOR, Kristen Lewis, MALHOTRA, Dheeraj, MCCARTHY, Shane E, STRAY, Sunday M, TAYLOR, Susan M

“…Individuals with autism are more likely to carry rare inherited and de novo copy number variants (CNVs). However, further research is needed to establish which…”
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Data structures and program design using C: a self-teaching introduction / Dheeraj Malhotra, Neha Malhotra by Malhotra, Dheeraj, Malhotra, Neha

“…"Data structures provide a means to manage large amounts of information such as large databases, using SEO, and creating Internet/Web indexing services. The…”
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The Influence of Microdeletions and Microduplications of 16p11.2 on Global Transcription Profiles by Kusenda, Mary, Vacic, Vladimir, Malhotra, Dheeraj, Rodgers, Linda, Pavon, Kevin, Meth, Jennifer, Kumar, Ravinesh A., Christian, Susan L., Peeters, Hilde, Cho, Shawn S., Addington, Anjene, Rapoport, Judith L., Sebat, Jonathan

“…Copy number variants (CNVs) of a 600 kb region on 16p11.2 are associated with neurodevelopmental disorders and changes in brain volume. The authors hypothesize…”
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Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis by TCW, Julia, Carvalho, Claudia M.B., Yuan, Bo, Gu, Shen, Altheimer, Alyssa N., McCarthy, Shane, Malhotra, Dheeraj, Sebat, Jonathan, Siegel, Arthur J., Rudolph, Uwe, Lupski, James R., Levy, Deborah L., Brennand, Kristen J.

“…In the process of generating presumably clonal human induced pluripotent stem cells (hiPSCs) from two carriers of a complex structural rearrangement, each…”
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Big data analytics for retail industry using MapReduce-Apriori framework by Verma, Neha, Malhotra, Dheeraj, Singh, Jatinder

“…Presently, retailing has changed its face from unordered stacked traditional stores to beautifully decorated and appropriately managed merchandise stores or…”
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Altered human oligodendrocyte heterogeneity in multiple sclerosis by Jäkel, Sarah, Agirre, Eneritz, Mendanha Falcão, Ana, van Bruggen, David, Lee, Ka Wai, Knuesel, Irene, Malhotra, Dheeraj, ffrench-Constant, Charles, Williams, Anna, Castelo-Branco, Gonçalo

“…Oligodendrocyte pathology is increasingly implicated in neurodegenerative diseases as oligodendrocytes both myelinate and provide metabolic support to axons…”
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Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders by Bryois, Julien, Calini, Daniela, Macnair, Will, Foo, Lynette, Urich, Eduard, Ortmann, Ward, Iglesias, Victor Alejandro, Selvaraj, Suresh, Nutma, Erik, Marzin, Manuel, Amor, Sandra, Williams, Anna, Castelo-Branco, Gonçalo, Menon, Vilas, De Jager, Philip, Malhotra, Dheeraj

“…To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in…”
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