Search Results - "MALHOTRA, Atul"

Low-Tidal-Volume Ventilation in the Acute Respiratory Distress Syndrome by Malhotra, Atul

“…A 55-year-old man is hospitalized with severe community-acquired pneumonia, and the acute respiratory distress syndrome (ARDS) develops. The patient requires…”
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Hypoglossal-Nerve Stimulation for Obstructive Sleep Apnea by Malhotra, Atul

“…Obstructive sleep apnea has well-established neurocognitive and cardiovascular sequelae. 1 Conservative estimates suggest that approximately 13% of men and 6%…”
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Adult obstructive sleep apnoea by Jordan, Amy S, Dr, McSharry, David G, MB, Malhotra, Atul, Prof

“…Summary Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway collapse during sleep, leading to oxygen desaturation and…”
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Editorial: Early Detection and Early Intervention Strategies for Cerebral Palsy in Low and High Resource Settings by Malhotra, Atul

“…Cerebral palsy (CP) is the most common physical disability in childhood [...]…”
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Defining Phenotypic Causes of Obstructive Sleep Apnea: Identification of Novel Therapeutic Targets by ECKERT, Danny J, WHITE, David P, JORDAN, Amy S, MALHOTRA, Atul, WELLMAN, Andrew

“…The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized. To define carefully the…”
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Metrics of sleep apnea severity: beyond the apnea-hypopnea index by Malhotra, Atul, Ayappa, Indu, Ayas, Najib, Collop, Nancy, Kirsch, Douglas, Mcardle, Nigel, Mehra, Reena, Pack, Allan I, Punjabi, Naresh, White, David P, Gottlieb, Daniel J

“…Abstract Obstructive sleep apnea (OSA) is thought to affect almost 1 billion people worldwide. OSA has well established cardiovascular and neurocognitive…”
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Sleep Hygiene for Optimizing Recovery in Athletes: Review and Recommendations by Vitale, Kenneth C, Owens, Roberts, Hopkins, Susan R, Malhotra, Atul

“…For elite athletes who exercise at a high level, sleep is critical to overall health. Many studies have documented the effects of sleep deprivation in the…”
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Driving Pressure and Respiratory Mechanics in ARDS by Loring, Stephen H, Malhotra, Atul

“…In this issue of the Journal, Amato et al. 1 use data from previously published trials to determine whether it is possible to predict outcomes in patients with…”
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Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants by Roberts, Calum T, Owen, Louise S, Manley, Brett J, Frøisland, Dag H, Donath, Susan M, Dalziel, Kim M, Pritchard, Margo A, Cartwright, David W, Collins, Clare L, Malhotra, Atul, Davis, Peter G

“…This multicenter trial comparing nasal high-flow therapy with CPAP as primary support for preterm infants with respiratory distress showed a significantly…”
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Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact by Malhotra, Atul, Allison, Beth J, Castillo-Melendez, Margie, Jenkin, Graham, Polglase, Graeme R, Miller, Suzanne L

“…Being born small lays the foundation for short-term and long-term implications for life. Intrauterine or fetal growth restriction describes the pregnancy…”
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Inherent vs. Induced Loop Gain Abnormalities in Obstructive Sleep Apnea by Deacon-Diaz, Naomi, Malhotra, Atul

“…Unstable ventilatory chemoreflex control, quantified as loop gain, is recognized as one of four key pathophysiological traits that contribute to cause…”
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Ventilator-induced Lung Injury by Beitler, Jeremy R., MD, MPH, Malhotra, Atul, MD, Thompson, B. Taylor, MD

“…Prevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI…”
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The Neurovascular Unit: Effects of Brain Insults During the Perinatal Period by Bell, Alexander H, Miller, Suzanne L, Castillo-Melendez, Margie, Malhotra, Atul

“…The neurovascular unit (NVU) is a relatively recent concept in neuroscience that broadly describes the relationship between brain cells and their blood…”
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Treatment of ARDS With Prone Positioning by Scholten, Eric L., MD, Beitler, Jeremy R., MD, MPH, Prisk, G. Kim, PhD, DSc, Malhotra, Atul, MD

“…Prone positioning was first proposed in the 1970s as a method to improve gas exchange in ARDS. Subsequent observations of dramatic improvement in oxygenation…”
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Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia by Rosas, Ivan O, Bräu, Norbert, Waters, Michael, Go, Ronaldo C, Hunter, Bradley D, Bhagani, Sanjay, Skiest, Daniel, Aziz, Mariam S, Cooper, Nichola, Douglas, Ivor S, Savic, Sinisa, Youngstein, Taryn, Del Sorbo, Lorenzo, Cubillo Gracian, Antonio, De La Zerda, David J, Ustianowski, Andrew, Bao, Min, Dimonaco, Sophie, Graham, Emily, Matharu, Balpreet, Spotswood, Helen, Tsai, Larry, Malhotra, Atul

“…In this randomized trial involving 438 hospitalized patients with severe Covid-19 pneumonia, the use of the monoclonal antibody tocilizumab did not result in…”
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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 by Lei, Yuyang, Zhang, Jiao, Schiavon, Cara R., He, Ming, Chen, Lili, Shen, Hui, Zhang, Yichi, Yin, Qian, Cho, Yoshitake, Andrade, Leonardo, Shadel, Gerald S., Hepokoski, Mark, Lei, Ting, Wang, Hongliang, Zhang, Jin, Yuan, Jason X.-J., Malhotra, Atul, Manor, Uri, Wang, Shengpeng, Yuan, Zu-Yi, Shyy, John Y-J.

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Endotypes and phenotypes in obstructive sleep apnea by Malhotra, Atul, Mesarwi, Omar, Pepin, Jean-Louis, Owens, Robert L.

“…PURPOSE OF REVIEWThe purpose of this review is to describe the variability of obstructive sleep apnea (OSA), both from a standpoint of underlying mechanisms…”
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Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis by Benjafield, Adam V, Ayas, Najib T, Eastwood, Peter R, Heinzer, Raphael, Ip, Mary S M, Morrell, Mary J, Nunez, Carlos M, Patel, Sanjay R, Penzel, Thomas, Pépin, Jean-Louis, Peppard, Paul E, Sinha, Sanjeev, Tufik, Sergio, Valentine, Kate, Malhotra, Atul

“…There is a scarcity of published data on the global prevalence of obstructive sleep apnoea, a disorder associated with major neurocognitive and cardiovascular…”
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Fixel-based Analysis of Diffusion MRI: Methods, Applications, Challenges and Opportunities by Dhollander, Thijs, Clemente, Adam, Singh, Mervyn, Boonstra, Frederique, Civier, Oren, Duque, Juan Dominguez, Egorova, Natalia, Enticott, Peter, Fuelscher, Ian, Gajamange, Sanuji, Genc, Sila, Gottlieb, Elie, Hyde, Christian, Imms, Phoebe, Kelly, Claire, Kirkovski, Melissa, Kolbe, Scott, Liang, Xiaoyun, Malhotra, Atul, Mito, Remika, Poudel, Govinda, Silk, Tim J., Vaughan, David N., Zanin, Julien, Raffelt, David, Caeyenberghs, Karen

“…•The fixel-based analysis framework was proposed for fibre-specific statistical analysis of diffusion MRI data.•A “fixel” represents an individual fibre…”
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Artificial intelligence sepsis prediction algorithm learns to say “I don’t know” by Shashikumar, Supreeth P., Wardi, Gabriel, Malhotra, Atul, Nemati, Shamim

“…Sepsis is a leading cause of morbidity and mortality worldwide. Early identification of sepsis is important as it allows timely administration of potentially…”
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