Search Results - "MALETINSKA, L"

Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration by Blechova, M, Kunes, J, Mikulaskova, B, Pirnik, Z, Maletinska, L, Lacinova, Z, Spolcova, A, Holubova, M, Zemenova, J, Haluzik, M, Zelezna, B, Nagelova, V, Ticha, A, Sykora, D

“…Objectives: Obesity is a frequent metabolic disorder but an effective therapy is still scarce. Anorexigenic neuropeptides produced and acting in the brain have…”
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Potential neuroprotective and anti-apoptotic properties of a long-lasting stable analog of ghrelin: an in vitro study using SH-SY5Y cells by Popelová, A, Kákonová, A, Hrubá, L, Kuneš, J, Maletínská, L, Železná, B

“…Neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are increasing in prevalence. Currently, there are no effective and…”
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Epigenetics and a new look on metabolic syndrome by Kuneš, J, Vaněčková, I, Mikulášková, B, Behuliak, M, Maletínská, L, Zicha, J

“…The incidence of metabolic syndrome increases in the developed countries, therefore biomedical research is focused on the understanding of its etiology. The…”
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The Peptidic GHS-R antagonist [D-Lys3]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity by Maletínská, L., Matyšková, R., Maixnerová, J., Sýkora, D., Pýchová, M., Špolcová, A., Blechová, M., Drápalová, J., Lacinová, Z., Haluzík, M., Železná, B.

“…► Estrogen deficient mice on high fat diet developed metabolic syndrome features. ► Ghrelin antagonist [D-Lys3]GHRP-6 improved metabolic parameters in these…”
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Pharmacological characterization of lipidized analogs of prolactin-releasing peptide with a modified C- terminal aromatic ring by Prazienkova, V, Ticha, A, Blechova, M, Spolcova, A, Zelezna, B, Maletinska, L

“…Prolactin-releasing peptide (PrRP) is an anorexigenic neuropeptide expressed in the brain where it regulates food intake and energy expenditure. The C-terminal…”
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Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice by Pirnik, Z., Bundziková, J., Holubová, M., Pýchová, M., Fehrentz, J.A., Martinez, J., Železná, B., Maletínská, L., Kiss, A.

“…► We studied three ghrelin agonist analogs on Fos expression in different brain areas. ► Each of the ghrelin agonists induced strong food intake increase. ►…”
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Comparison of the obesity phenotypes related to monosodium glutamate effect on arcuate nucleus and/or the high fat diet feeding in C57BL/6 and NMRI mice by Matyšková, R, Maletínská, L, Maixnerová, J, Pirník, Z, Kiss, A, Železná, B

“…In this study, susceptibility of inbred C57BL/6 and outbred NMRI mice to monosodium glutamate (MSG) obesity or diet-induced obesity (DIO) was compared in terms…”
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Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice by Holubová, M., Nagelová, V., Lacinová, Z., Haluzík, M., Sýkora, D., Moulin, A., Blayo, A.L., Fehrentz, J.A., Martinez, J., Stofkova, A., Jurčovičová, J., Železná, B., Maletínská, L.

“…•JMV4208 and JMV3002 decrease fasting-induced food intake in lean mice.•Both drugs promptly enter the blood stream and their half-life is 90 and 60min.•14-Day…”
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Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes by Spolcová, A, Holubová, M, Mikulášková, B, Nagelová, V, Stofková, A, Lacinová, Z, Jurčovičová, J, Haluzík, M, Maletínská, L, Zelezná, B

“…Patients with obesity and type 2 diabetes often display high levels of the anti-diabetic factor fibroblast growth factor-21 (FGF21), suggesting that the…”
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Estradiol supplementation helps overcome central leptin resistance of ovariectomized mice on a high fat diet by Matysková, R, Zelezná, B, Maixnerová, J, Koutová, D, Haluzík, M, Maletínská, L

“…Ovariectomized mice on a high fat diet represent a model of diet-induced obesity during estrogen deficiency. Here, we tested the hypothesis that sensitivity to…”
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Effect of ghrelin receptor agonist and antagonist on the activity of arcuate nucleus tyrosine hydroxylase containing neurons in C57BL/6 male mice exposed to normal or high fat diet by Pirnik, Z, Majercikova, Z, Holubova, M, Pirnik, R, Zelezna, B, Maletinska, L, Kiss, A

“…Catecholamines participate in the food intake regulation, however, there are no literature data available, dealing with the activity of tyrosine hydroxylase…”
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Ghrelin agonist JMV 1843 increases food intake, body weight and expression of orexigenic neuropeptides in mice by Holubová, M, Spolcová, A, Demianová, Z, Sýkora, D, Fehrentz, J A, Martinez, J, Stofková, A, Jurčovičová, J, Drápalová, J, Lacinová, Z, Haluzík, M, Zelezná, B, Maletínská, L

“…Ghrelin and agonists of its receptor GHS-R1a are potential substances for the treatment of cachexia. In the present study, we investigated the acute and long…”
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Anorexigenic effect of cholecystokinin is lost but that of CART (Cocaine and Amphetamine Regulated Transcript) peptide is preserved in monosodium glutamate obese mice by Železná, B, Maixnerová, J, Matyšková, R, Haugvicová, R, Blokešová, D, Maletínská, L

“…Monosodium glutamate (MSG) treatment of neonatal mice results in a selective damage to the arcuate nucleus (ARC) and development of obesity with increased…”
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The role of food intake regulating peptides in cardiovascular regulation by Mikulášková, B., Maletínská, L., Zicha, J., Kuneš, J.

“…Obesity is a risk factor that worsens cardiovascular events leading to higher morbidity and mortality. However, the exact mechanisms of relation between…”
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Substitution of the Side-Chain-Constrained Amino Acids β-Methyl-2‘,6‘-Dimethyl-4‘-Methoxytyrosine in Position 2 of a Bicyclic Oxytocin Analogue Provides Unique Insights into the Bioactive Topography of Oxytocin Antagonists by Liao, Subo, Shenderovich, Mark D, Zhang, Zhigang, Maletinska, Lenka, Slaninova, Jirina, Hruby, Victor J

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Human glioblastoma cell lines : Levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein by MALETINSKA, L, BLAKELY, E. A, BJORNSTAD, K. A, DEEN, D. F, KNOFF, L. J, FORTE, T. M

“…The status of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein (LRP) in seven human glioma cell lines was evaluated to extend our…”
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The influence of steric interactions on the conformation and biology of oxytocin. Synthesis and analysis of penicillamine(6)-oxytocin and penicillamine(6)-5-tert-butylproline(7)-oxytocin analogs by Bélec, L, Maletinska, L, Slaninová, J, Lubell, W D

“…Six [Pen(6)]oxytocin analogs were synthesized by substituting penicillamine for cysteine in oxytocin, [Mpa(1)]oxytocin, [dPen(1)]oxytocin,…”
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Glutathione Levels and Lipid Oxidative Damage in Selected Organs of Obese Koletsky and Lean Spontaneously Hypertensive Rats by Rauchová, H, Neprašová, B, Maletínská, L, Kuneš, J

“…Koletsky rats, the genetically obese strain of spontaneously hypertensive rats (SHROB), are the well-accepted animal model of human metabolic syndrome. They…”
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Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms by Kuneš, J, Hojná, S, Mráziková, L, Montezano, A, Touyz, RM, Maletínská, L

“…The worldwide increase in the incidence of obesity and cardiovascular and neurodegenerative diseases, e.g. Alzheimer's disease, is related to many factors,…”
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High-Fat Diet Induces Resistance to Ghrelin and LEAP2 Peptide Analogs in Mice by Holá, L, Tureckiuová, T, Kuneš, J, Železná, B, Maletínská, L

“…Recent data suggest that the orexigenic peptide ghrelin and liver-expressed antimicrobial peptide 2 (LEAP2) have opposing effects on food intake regulation…”
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