Search Results - "MALEMUD, Charles J"

The role of the JAK/STAT signal pathway in rheumatoid arthritis by Malemud, Charles J.

“…Proinflammatory cytokine activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signal transduction pathway is a critical…”
Get full text

Matrix Metalloproteinases and Synovial Joint Pathology by Malemud, Charles J

“…Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a critical role in the destruction of articular cartilage in rheumatoid…”
Get full text

Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression by Lu, Nathan, Malemud, Charles J

“…Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family of signaling molecules. ERK is predominantly found in…”
Get full text

The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis? by Malemud, Charles J

“…PI3K/Akt/mTOR signaling regulates diverse cellular processes. Abnormal PI3K/Akt/mTOR signaling is a characteristic feature of cancer. As such inhibition of…”
Get full text

Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis by Malemud, Charles J

“…Elevated levels of pro-inflammatory cytokines are generally thought to be responsible for driving the progression of synovial joint inflammation in rheumatoid…”
Get full text

Matrix metalloproteinases (MMPs) in health and disease: an overview by Malemud, Charles J

“…Matrix metalloproteinases (MMPs) are members of an enzyme family that require a zinc ion in their active site for catalytic activity. MMPs are critical for…”
Get full text

MicroRNAs and Osteoarthritis by Malemud, Charles J

“…An imbalance in gene expressional events skewing chondrocyte anabolic and catabolic pathways toward the latter causes an aberrant turnover and loss of…”
Get full text

Inhibition of MMPs and ADAM/ADAMTS by Malemud, Charles J.

“…[Display omitted] Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin…”
Get full text

Defective T-Cell Apoptosis and T-Regulatory Cell Dysfunction in Rheumatoid Arthritis by Malemud, Charles J

“…Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune disease that mostly affects small and large synovial joints. At the molecular level,…”
Get full text

Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis by Mandel, Dana E, Malemud, Charles J, Askari, Ali D

“…Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune muscle diseases with significant morbidity and mortality. This review details and updates…”
Get full text

The Relationship between NALP3 and Autoinflammatory Syndromes by Campbell, Lorna, Raheem, Irfan, Malemud, Charles J, Askari, Ali D

“…The nucleotide-binding domain, leucine-rich repeat/pyrin domain-containing-3 (NALP3) inflammasome, which is required for synthesis of interleukin-1β, has been…”
Get full text

A Role for Soluble IL-6 Receptor in Osteoarthritis by Akeson, Graham, Malemud, Charles J

“…Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical…”
Get full text

Biologic basis of osteoarthritis: state of the evidence by Malemud, Charles J

“…PURPOSE OF REVIEWEvidence accumulated since 2010 indicates that human osteoarthritis should now be reclassified as a systemic musculoskeletal disease rather…”
Get full text

Prospects for treating osteoarthritis: enzyme–protein interactions regulating matrix metalloproteinase activity by Meszaros, Evan, Malemud, Charles J.

“…Primary osteoarthritis (OA) is a musculoskeletal disorder of unknown etiology. OA is characterized by an imbalance between anabolism and catabolism in, and…”
Get full text

Matrix metalloproteinases: role in skeletal development and growth plate disorders by Malemud, Charles J

“…Differentiation is the cellular process that regulates development of long bones and joint surface cartilage of synovial cavities. Growth plate cartilage…”
Get full text

Anticytokine Therapy for Osteoarthritis: Evidence to Date by Malemud, Charles J.

“…Several recent in vitro investigations and experimental studies performed in animal models of osteoarthritis (OA) sustained the previously held view that…”
Get full text

Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies by Malemud, Charles J, Islam, Najmul, Haqqi, Tariq M

“…Osteoarthritis (OA) is a debilitating, progressive disease of diarthrodial joints associated with aging. At the molecular level, OA is characterized by an…”
Get more information

Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway by Malemud, Charles J

“…A skewed ratio of pro-inflammatory to anti-inflammatory cytokines, elevated growth factor synthesis and T- and B-lymphocyte activation are 3 hallmarks of…”
Get full text

Red Cell Distribution Width Is Positively Correlated with Atherosclerotic Cardiovascular Disease 10-Year Risk Score, Age, and CRP in Spondyloarthritis with Axial or Peripheral Disease by Zidar, David A., Anthony, Donald D., Blumenthal, David E., Askari, Ali D., Malemud, Charles J., Burant, Christopher, Jackson, Desmond A., Laugle, Michelle, Khan, Mariam, Ahmad, Hassan, Mattar, Maya

“…Background. Red blood cell distribution width (RDW) is a routine hematologic parameter that is a predictor of cardiovascular disease (CVD) events and is…”
Get full text

Role of the Growth Hormone/Insulin-like Growth Factor-1 Paracrine Axis in Rheumatic Diseases by Denko, Charles W., Malemud, Charles J.

“…Hypothalamic-pituitary axis abnormalities have been associated with systemic disturbances in several rheumatic diseases. Longitudinal analysis of erythrocyte,…”
Get full text