Search Results - "MALEK, P"

A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas by Zender, Steffen, Nickeleit, Irina, Wuestefeld, Torsten, Sörensen, Inga, Dauch, Daniel, Bozko, Przemyslaw, El-Khatib, Mona, Geffers, Robert, Bektas, Hueseyin, Manns, Michael P., Gossler, Achim, Wilkens, Ludwig, Plentz, Ruben, Zender, Lars, Malek, Nisar P.

“…The incidence of cholangiocellular carcinoma (CCC) is increasing worldwide. Using a transgenic mouse model, we found that expression of the intracellular…”
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Hypoxia induced Sonic Hedgehog signaling regulates cancer stemness, epithelial-to-mesenchymal transition and invasion in cholangiocarcinoma by Bhuria, Vikas, Xing, Jun, Scholta, Tim, Bui, Khac Cuong, Nguyen, Mai Ly Thi, Malek, Nisar P., Bozko, Przemyslaw, Plentz, Ruben R.

“…Aberrant activation of Sonic Hedgehog (SHH) pathway has been implicated in a variety of cancers including cholangiocarcinoma (CC); however, the influencing…”
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A researcher’s guide to preclinical mouse NASH models by Gallage, Suchira, Avila, Jose Efren Barragan, Ramadori, Pierluigi, Focaccia, Enrico, Rahbari, Mohammad, Ali, Adnan, Malek, Nisar P., Anstee, Quentin M., Heikenwalder, Mathias

“…Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic steatohepatitis (NASH), have quickly risen to become the most prevalent…”
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A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration by Wuestefeld, Torsten, Pesic, Marina, Rudalska, Ramona, Dauch, Daniel, Longerich, Thomas, Kang, Tae-Won, Yevsa, Tetyana, Heinzmann, Florian, Hoenicke, Lisa, Hohmeyer, Anja, Potapova, Anna, Rittelmeier, Ina, Jarek, Michael, Geffers, Robert, Scharfe, Maren, Klawonn, Frank, Schirmacher, Peter, Malek, Nisar P., Ott, Michael, Nordheim, Alfred, Vogel, Arndt, Manns, Michael P., Zender, Lars

“…The liver harbors a distinct capacity for endogenous regeneration; however, liver regeneration is often impaired in disease and therefore insufficient to…”
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Activation of Notch signaling is required for cholangiocarcinoma progression and is enhanced by inactivation of p53 in vivo by El Khatib, Mona, Bozko, Przemyslaw, Palagani, Vindhya, Malek, Nisar P, Wilkens, Ludwig, Plentz, Ruben R

“…Cholangiocacinoma (CC) is a cancer disease with rising incidence. Notch signaling has been shown to be deregulated in many cancers. However, the role of this…”
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Decentralized desalination of brackish water using an electrodialysis system directly powered by wind energy by Malek, P., Ortiz, J.M., Schulte-Herbrüggen, H.M.A.

“…A novel directly coupled wind–electrodialysis system (wind–ED) with no energy storage was developed. The aim was to perform laboratory experiments,…”
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Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action by Raschig, Judith, Mailänder-Sánchez, Daniela, Berscheid, Anne, Berger, Jürgen, Strömstedt, Adam A, Courth, Lioba F, Malek, Nisar P, Brötz-Oesterhelt, Heike, Wehkamp, Jan

“…Ever since the discovery of endogenous host defense antimicrobial peptides it has been discussed how these evolutionary conserved molecules avoid to induce…”
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Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma – The SHELTER study by Bitzer, Michael, Horger, Marius, Giannini, Edoardo G, Ganten, Tom M, Wörns, Marcus A, Siveke, Jens T, Dollinger, Matthias M, Gerken, Guido, Scheulen, Max E, Wege, Henning, Zagonel, Vittorina, Cillo, Umberto, Trevisani, Franco, Santoro, Armando, Montesarchio, Vincenzo, Malek, Nisar P, Holzapfel, Julia, Herz, Thomas, Ammendola, Astrid S, Pegoraro, Stefano, Hauns, Bernhard, Mais, Anna, Lauer, Ulrich M, Henning, Stefan W, Hentsch, Bernd

“…Graphical abstract…”
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Quality of life in inflammatory bowel diseases: it is not all about the bowel by Keller, Ronald, Mazurak, Nazar, Fantasia, Laura, Fusco, Stefano, Malek, Nisar P, Wehkamp, Jan, Enck, Paul, Klag, Thomas

“…Background/Aims: The inflammatory bowel diseases (IBD), ulcerative colitis (UC), and Crohn’s disease (CD) are chronic diseases mostly affecting young patients…”
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Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis by Koeninger, Louis, Armbruster, Nicole S, Brinch, Karoline Sidelmann, Kjaerulf, Søren, Andersen, Birgitte, Langnau, Carolin, Autenrieth, Stella E, Schneidawind, Dominik, Stange, Eduard F, Malek, Nisar P, Nordkild, Peter, Jensen, Benjamin A H, Wehkamp, Jan

“…Defensins represents an integral part of the innate immune system serving to ward off potential pathogens and to protect the intestinal barrier from microbial…”
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Crohn’s disease-derived monocytes fail to induce Paneth cell defensins by Courth, Lioba F., Ostaff, Maureen J., Mailänder-Sánchez, Daniela, Malek, Nisar P., Stange, Eduard F., Wehkamp, Jan

“…Crohn’s disease (CD) is associated with a multitude of genetic defects, many of which likely affect Paneth cell function. Paneth cells reside in the small…”
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Clinical presentation, risk factors and staging systems of cholangiocarcinoma by Plentz, Ruben R., MD, PD, Malek, Nisar P., MD

“…Abstract Cholangiocarcinoma (CCA) is the second most common primary liver tumour. Intra-hepatic CCA develops within the liver parenchyma while extrahepatic CCA…”
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The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma by Spahn, Stephan, Kleinhenz, Fabian, Shevchenko, Ekaterina, Stahl, Aaron, Rasen, Yvonne, Geisler, Christine, Ruhm, Kristina, Klaumuenzer, Marion, Kronenberger, Thales, Laufer, Stefan A., Sundberg-Malek, Holly, Bui, Khac Cuong, Horger, Marius, Biskup, Saskia, Schulze-Osthoff, Klaus, Templin, Markus, Malek, Nisar P., Poso, Antti, Bitzer, Michael

“…Fibroblast growth factor receptor (FGFR)−2 can be inhibited by FGFR-selective or non-selective tyrosine kinase inhibitors (TKIs). Selective TKIs are approved…”
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The German Network for Personalized Medicine to enhance patient care and translational research by Illert, A. L., Stenzinger, A., Bitzer, M., Horak, P., Gaidzik, V. I., Möller, Y., Beha, J., Öner, Ö., Schmitt, F., Laßmann, S., Ossowski, S., Schaaf, C. P., Hallek, M., Brümmendorf, T. H., Albers, P., Fehm, T., Brossart, P., Glimm, H., Schadendorf, D., Bleckmann, A., Brandts, C. H., Esposito, I., Mack, E., Peters, C., Bokemeyer, C., Fröhling, S., Kindler, T., Algül, H., Heinemann, V., Döhner, H., Bargou, R., Ellenrieder, V., Hillemanns, P., Lordick, F., Hochhaus, A., Beckmann, M. W., Pukrop, T., Trepel, M., Sundmacher, L., Wesselmann, S., Nettekoven, G., Kohlhuber, F., Heinze, O., Budczies, J., Werner, M., Nikolaou, K., Beer, A. J., Tabatabai, G., Weichert, W., Keilholz, U., Boerries, M., Kohlbacher, O., Duyster, J., Thimme, R., Seufferlein, T., Schirmacher, P., Malek, N. P.

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Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma by Spahn, Stephan, Roessler, Daniel, Pompilia, Radu, Gabernet, Gisela, Gladstone, Beryl Primrose, Horger, Marius, Biskup, Saskia, Feldhahn, Magdalena, Nahnsen, Sven, Hilke, Franz J, Scheiner, Bernhard, Dufour, Jean-François, De Toni, Enrico N, Pinter, Matthias, Malek, Nisar P, Bitzer, Michael

“…Immune checkpoint inhibitors (ICIs) belong to the therapeutic armamentarium in advanced hepatocellular carcinoma (HCC). However, only a minority of patients…”
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The SCF-Fbxw5 E3-ubiquitin ligase is regulated by Plk4 and targets HsSAS-6 to control centrosome duplication by Malek, Nisar P, Puklowski, Anja, Homsi, Yahya, Keller, Debora, May, Martin, Chauhan, Sangeeta, Kossatz, Uta, Grünwald, Viktor, Kubicka, Stefan, Pich, Andreas, Manns, Michael P, Hoffmann, Ingrid, Gönczy, Pierre

“…Deregulated centrosome duplication can result in genetic instability and contribute to tumorigenesis. Here, we show that centrosome duplication is regulated by…”
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Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12 by Werner, Christoph R, Schwarz, Julia M, Egetemeyr, Daniel P, Beck, Robert, Malek, Nisar P, Lauer, Ulrich M, Berg, Christoph P

“…AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological…”
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Deregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of Chronic Lymphocytic Leukemia? by Podhorecka, Monika, Macheta, Arkadiusz, Bozko, Maria, Bozko, Andrzej, Malek, Nisar P, Bozko, Przemyslaw

“…Chronic lymphocytic leukemia (CLL), a clonal expansion of B CD5+ cells, is the most common type of adult leukemia in western countries. The accumulation of…”
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Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue by Stebe-Frick, Sabrina, Ostaff, Maureen J., Stange, Eduard F., Malek, Nisar P., Wehkamp, Jan

“…Histone deacetylase inhibition (HDACi) has been suggested as a promising approach to bolster TLR-mediated induction of antimicrobial peptides such as human…”
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Differences in fluid removal of different open-pore elements for endoscopic negative pressure therapy in the upper gastrointestinal tract by Jansen, Kai Tobias, Hetzel, Jürgen, Schulte, Carola, Düzenli, Nurgül, Fusco, Stefano, Zerabruck, Emanuel, Schmider, Eva, Malek, Nisar P., Königsrainer, Alfred, Stüker, Dietmar, Werner, Christoph R., Wichmann, Dörte

“…Endoscopic negative pressure therapy is an effective treatment strategy for various defects of the gastrointestinal tract. The functional principle is based on…”
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